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Prenatal ultrasound diagnosis of the Holt-Oram syndrome.
Prenat Diagn 1988; 8(3):175-81PD

Abstract

The Holt-Oram syndrome is an autosomal dominant disorder consisting of a congenital heart defect in combination with characteristic upper limb abnormalities. This report presents the ultrasonographic follow-up of two fetuses at risk for the Holt-Oram syndrome. In the first fetus, the existence of Holt-Oram syndrome was suspected at 22 weeks of gestation; a ventricular septal defect, an atrial septal defect, and a minor skeletal defect were found. In the second fetus, no structural abnormalities were discovered until the 30th week, when a small atrial septal defect was detected. In both pregnancies, it was possible to exclude early in gestation the more severe forms of the Holt-Oram syndrome.

Authors+Show Affiliations

Department of Obstetrics and Gynaecology, Academisch Ziekenhuis Vrije Universiteit, Amsterdam, The Netherlands.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Case Reports
Journal Article

Language

eng

PubMed ID

3287365

Citation

Brons, J T., et al. "Prenatal Ultrasound Diagnosis of the Holt-Oram Syndrome." Prenatal Diagnosis, vol. 8, no. 3, 1988, pp. 175-81.
Brons JT, van Geijn HP, Wladimiroff JW, et al. Prenatal ultrasound diagnosis of the Holt-Oram syndrome. Prenat Diagn. 1988;8(3):175-81.
Brons, J. T., van Geijn, H. P., Wladimiroff, J. W., van der Harten, J. J., Kwee, M. L., Sobotka-Plojhar, M., & Arts, N. F. (1988). Prenatal ultrasound diagnosis of the Holt-Oram syndrome. Prenatal Diagnosis, 8(3), pp. 175-81.
Brons JT, et al. Prenatal Ultrasound Diagnosis of the Holt-Oram Syndrome. Prenat Diagn. 1988;8(3):175-81. PubMed PMID: 3287365.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Prenatal ultrasound diagnosis of the Holt-Oram syndrome. AU - Brons,J T, AU - van Geijn,H P, AU - Wladimiroff,J W, AU - van der Harten,J J, AU - Kwee,M L, AU - Sobotka-Plojhar,M, AU - Arts,N F, PY - 1988/3/1/pubmed PY - 1988/3/1/medline PY - 1988/3/1/entrez SP - 175 EP - 81 JF - Prenatal diagnosis JO - Prenat. Diagn. VL - 8 IS - 3 N2 - The Holt-Oram syndrome is an autosomal dominant disorder consisting of a congenital heart defect in combination with characteristic upper limb abnormalities. This report presents the ultrasonographic follow-up of two fetuses at risk for the Holt-Oram syndrome. In the first fetus, the existence of Holt-Oram syndrome was suspected at 22 weeks of gestation; a ventricular septal defect, an atrial septal defect, and a minor skeletal defect were found. In the second fetus, no structural abnormalities were discovered until the 30th week, when a small atrial septal defect was detected. In both pregnancies, it was possible to exclude early in gestation the more severe forms of the Holt-Oram syndrome. SN - 0197-3851 UR - https://www.unboundmedicine.com/medline/citation/3287365/Prenatal_ultrasound_diagnosis_of_the_Holt_Oram_syndrome_ L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=0197-3851&date=1988&volume=8&issue=3&spage=175 DB - PRIME DP - Unbound Medicine ER -