Tags

Type your tag names separated by a space and hit enter

Difference in levels of SARS-CoV-2 S1 and S2 subunits- and nucleocapsid protein-reactive SIgM/IgM, IgG and SIgA/IgA antibodies in human milk.
J Perinatol. 2021 04; 41(4):850-859.JP

Abstract

OBJECTIVE

This study evaluated the presence and the levels of antibodies reactive to SARS-CoV-2 S1 and S2 subunits (S1 + S2), and nucleocapsid protein.

STUDY DESIGN

The levels of SARS-CoV-2 S1 + S2- and nucleocapsid-reactive SIgM/IgM, IgG and SIgA/IgA were measured in human milk samples from 41 women during the COVID-19 pandemic (2020-HM) and from 16 women 2 years prior to the outbreak (2018-HM).

RESULTS

SARS-CoV-2 S1 + S2-reactive SIgA/IgA, SIgM/IgM and IgG were detected in 97.6%, 68.3% and 58.5% in human milk whereas nucleocapsid-reactive antibodies were detected in 56.4%, 87.2% and 46.2%, respectively. S1 + S2-reactive IgG was higher in milk from women that had symptoms of viral respiratory infection(s) during the last year than in milk from women without symptom. S1 + S2- and nucleocapsid-reactive IgG were higher in the 2020-HM group compared to the 2018-HM group.

CONCLUSIONS

The presence of SARS-CoV-2-reactive antibodies in human milk could provide passive immunity to breastfed infants and protect them against COVID-19 diseases.

Authors+Show Affiliations

Department of Neonatal Immunology and Microbiology, Medolac Laboratories A Public Benefit Corporation, Boulder City, NV, USA. vdemers-m@medolac.com. Department of Food Science, University of Massachusetts Amherst, Amherst, MA, USA. vdemers-m@medolac.com.Department of Neonatal Immunology and Microbiology, Medolac Laboratories A Public Benefit Corporation, Boulder City, NV, USA.Department of Neonatal Immunology and Microbiology, Medolac Laboratories A Public Benefit Corporation, Boulder City, NV, USA.Department of Food Science, University of Massachusetts Amherst, Amherst, MA, USA.Department of Pediatrics, Pediatric Allergy/Immunology, University of Rochester, Medical Center, Rochester, NY, USA.Department of Pediatrics, Pediatric Allergy/Immunology, University of Rochester, Medical Center, Rochester, NY, USA.Department of Neonatal Immunology and Microbiology, Medolac Laboratories A Public Benefit Corporation, Boulder City, NV, USA.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

32873904

Citation

Demers-Mathieu, Veronique, et al. "Difference in Levels of SARS-CoV-2 S1 and S2 Subunits- and Nucleocapsid Protein-reactive SIgM/IgM, IgG and SIgA/IgA Antibodies in Human Milk." Journal of Perinatology : Official Journal of the California Perinatal Association, vol. 41, no. 4, 2021, pp. 850-859.
Demers-Mathieu V, Do DM, Mathijssen GB, et al. Difference in levels of SARS-CoV-2 S1 and S2 subunits- and nucleocapsid protein-reactive SIgM/IgM, IgG and SIgA/IgA antibodies in human milk. J Perinatol. 2021;41(4):850-859.
Demers-Mathieu, V., Do, D. M., Mathijssen, G. B., Sela, D. A., Seppo, A., Järvinen, K. M., & Medo, E. (2021). Difference in levels of SARS-CoV-2 S1 and S2 subunits- and nucleocapsid protein-reactive SIgM/IgM, IgG and SIgA/IgA antibodies in human milk. Journal of Perinatology : Official Journal of the California Perinatal Association, 41(4), 850-859. https://doi.org/10.1038/s41372-020-00805-w
Demers-Mathieu V, et al. Difference in Levels of SARS-CoV-2 S1 and S2 Subunits- and Nucleocapsid Protein-reactive SIgM/IgM, IgG and SIgA/IgA Antibodies in Human Milk. J Perinatol. 2021;41(4):850-859. PubMed PMID: 32873904.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Difference in levels of SARS-CoV-2 S1 and S2 subunits- and nucleocapsid protein-reactive SIgM/IgM, IgG and SIgA/IgA antibodies in human milk. AU - Demers-Mathieu,Veronique, AU - Do,Dung M, AU - Mathijssen,Gabrielle B, AU - Sela,David A, AU - Seppo,Antti, AU - Järvinen,Kirsi M, AU - Medo,Elena, Y1 - 2020/09/01/ PY - 2020/05/07/received PY - 2020/08/25/accepted PY - 2020/08/03/revised PY - 2020/9/3/pubmed PY - 2021/4/28/medline PY - 2020/9/3/entrez SP - 850 EP - 859 JF - Journal of perinatology : official journal of the California Perinatal Association JO - J Perinatol VL - 41 IS - 4 N2 - OBJECTIVE: This study evaluated the presence and the levels of antibodies reactive to SARS-CoV-2 S1 and S2 subunits (S1 + S2), and nucleocapsid protein. STUDY DESIGN: The levels of SARS-CoV-2 S1 + S2- and nucleocapsid-reactive SIgM/IgM, IgG and SIgA/IgA were measured in human milk samples from 41 women during the COVID-19 pandemic (2020-HM) and from 16 women 2 years prior to the outbreak (2018-HM). RESULTS: SARS-CoV-2 S1 + S2-reactive SIgA/IgA, SIgM/IgM and IgG were detected in 97.6%, 68.3% and 58.5% in human milk whereas nucleocapsid-reactive antibodies were detected in 56.4%, 87.2% and 46.2%, respectively. S1 + S2-reactive IgG was higher in milk from women that had symptoms of viral respiratory infection(s) during the last year than in milk from women without symptom. S1 + S2- and nucleocapsid-reactive IgG were higher in the 2020-HM group compared to the 2018-HM group. CONCLUSIONS: The presence of SARS-CoV-2-reactive antibodies in human milk could provide passive immunity to breastfed infants and protect them against COVID-19 diseases. SN - 1476-5543 UR - https://www.unboundmedicine.com/medline/citation/32873904/Difference_in_levels_of_SARS_CoV_2_S1_and_S2_subunits__and_nucleocapsid_protein_reactive_SIgM/IgM_IgG_and_SIgA/IgA_antibodies_in_human_milk_ L2 - https://doi.org/10.1038/s41372-020-00805-w DB - PRIME DP - Unbound Medicine ER -