Citation
Varnaitė, Renata, et al. "Expansion of SARS-CoV-2-Specific Antibody-Secreting Cells and Generation of Neutralizing Antibodies in Hospitalized COVID-19 Patients." Journal of Immunology (Baltimore, Md. : 1950), vol. 205, no. 9, 2020, pp. 2437-2446.
Varnaitė R, García M, Glans H, et al. Expansion of SARS-CoV-2-Specific Antibody-Secreting Cells and Generation of Neutralizing Antibodies in Hospitalized COVID-19 Patients. J Immunol. 2020;205(9):2437-2446.
Varnaitė, R., García, M., Glans, H., Maleki, K. T., Sandberg, J. T., Tynell, J., Christ, W., Lagerqvist, N., Asgeirsson, H., Ljunggren, H. G., Ahlén, G., Frelin, L., Sällberg, M., Blom, K., Klingström, J., & Gredmark-Russ, S. (2020). Expansion of SARS-CoV-2-Specific Antibody-Secreting Cells and Generation of Neutralizing Antibodies in Hospitalized COVID-19 Patients. Journal of Immunology (Baltimore, Md. : 1950), 205(9), 2437-2446. https://doi.org/10.4049/jimmunol.2000717
Varnaitė R, et al. Expansion of SARS-CoV-2-Specific Antibody-Secreting Cells and Generation of Neutralizing Antibodies in Hospitalized COVID-19 Patients. J Immunol. 2020 11 1;205(9):2437-2446. PubMed PMID: 32878912.
TY - JOUR
T1 - Expansion of SARS-CoV-2-Specific Antibody-Secreting Cells and Generation of Neutralizing Antibodies in Hospitalized COVID-19 Patients.
AU - Varnaitė,Renata,
AU - García,Marina,
AU - Glans,Hedvig,
AU - Maleki,Kimia T,
AU - Sandberg,John Tyler,
AU - Tynell,Janne,
AU - Christ,Wanda,
AU - Lagerqvist,Nina,
AU - Asgeirsson,Hilmir,
AU - Ljunggren,Hans-Gustaf,
AU - Ahlén,Gustaf,
AU - Frelin,Lars,
AU - Sällberg,Matti,
AU - Blom,Kim,
AU - Klingström,Jonas,
AU - Gredmark-Russ,Sara,
Y1 - 2020/09/02/
PY - 2020/06/15/received
PY - 2020/08/20/accepted
PY - 2020/9/4/pubmed
PY - 2020/10/28/medline
PY - 2020/9/4/entrez
SP - 2437
EP - 2446
JF - Journal of immunology (Baltimore, Md. : 1950)
JO - J Immunol
VL - 205
IS - 9
N2 - Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), emerged in late 2019 and has since become a global pandemic. Pathogen-specific Abs are typically a major predictor of protective immunity, yet human B cell and Ab responses during COVID-19 are not fully understood. In this study, we analyzed Ab-secreting cell and Ab responses in 20 hospitalized COVID-19 patients. The patients exhibited typical symptoms of COVID-19 and presented with reduced lymphocyte numbers and increased T cell and B cell activation. Importantly, we detected an expansion of SARS-CoV-2 nucleocapsid protein-specific Ab-secreting cells in all 20 COVID-19 patients using a multicolor FluoroSpot Assay. Out of the 20 patients, 16 had developed SARS-CoV-2-neutralizing Abs by the time of inclusion in the study. SARS-CoV-2-specific IgA, IgG, and IgM Ab levels positively correlated with SARS-CoV-2-neutralizing Ab titers, suggesting that SARS-CoV-2-specific Ab levels may reflect the titers of neutralizing Abs in COVID-19 patients during the acute phase of infection. Last, we showed that IL-6 and C-reactive protein serum concentrations were higher in patients who were hospitalized for longer, supporting the recent observations that IL-6 and C-reactive protein could be used as markers for COVID-19 severity. Altogether, this study constitutes a detailed description of clinical and immunological parameters in 20 COVID-19 patients, with a focus on B cell and Ab responses, and describes tools to study immune responses to SARS-CoV-2 infection and vaccination.
SN - 1550-6606
UR - https://www.unboundmedicine.com/medline/citation/32878912/Expansion_of_SARS_CoV_2_Specific_Antibody_Secreting_Cells_and_Generation_of_Neutralizing_Antibodies_in_Hospitalized_COVID_19_Patients_
DB - PRIME
DP - Unbound Medicine
ER -