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Clinical characteristics of 71 patients with coronavirus disease 2019.
Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2020 Jul 28; 45(7):790-796.ZN

Abstract

OBJECTIVES

To analyze the clinical characteristics of 71 patients with coronavirus disease 2019 (COVID-19).

METHODS

The general data, epidemiological data, laboratory tests, imaging examinations, and treatment of 71 patients with COVID-19 admitted to the Sixth People's Hospital of Zhengzhou from January 19, 2020 to March 3, 2020 were retrospectively analyzed.

RESULTS

Of the 71 COVID-19 patients, the ages were 4-84 (41.29±15.21) years, 38 (53.5%) patients were male, 33 (46.5%) were female, and 52 (73.2%) were in 22 clusters. The main clinical manifestations were fever (78.9%), cough (64.8%), and sputum (38.0%). The fever was mainly low and moderate, with 49 patients (69.0%) at 37.3-39.0 ℃. Most of the leukocytes, neutrophils, and lymphocytes were normal, accounting for 47 (66.2%), 51 (71.8%), and 51 (71.8%) patients, respectively; a few of them were decreased, accounting for 21 (29.6%), 16 (22.5%), and 20 (28.2%) patients, respectively. There were 38 (53.5%) and 31 (43.7%) patients with the decreased CD4+ and CD8+ T cell counts, respectively. There were 41 (57.7%), 38 (53.5%), 32 (45.1%), 26(36.6%), 22 (31.0%), 20 (28.2%), 14 (19.7%), 14 (19.7%), and 9 (12.7%) patients with the increased levels of C-reactive protein, erythrocyte sedimentation rate, procalcitonin, fibrinogen,interleukin 6, lactate dehydrogenase,D-dimer,alanine aminotransferase, and aspartate aminotransferase, respectively. Of the 71 patients, the lung was involved in 60 (84.5%) patients, the double lung was involved in 47 (66.2%) patients, and the single lung was involved in 13 (18.3%) patients. The course of the disease was long, and the time from symptom onset to the second severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) nucleic acid negative transformation was (17.22±6.34) days.There were no significant differences in the incubation period (t=-0.453, P>0.05), the complicates (χ2=0.042, P>0.05), and the time from symptom onset to diagnosis (t=-1.330, P>0.05) in patients between the non-severe group and the severe group. The onset age, gender, SARS-CoV-2 nucleic acid negative time, lymphocyte count, D-dimer, C-reactive protein, total bilirubin, direct bilirubin, lactate dehydrogenase, calcium ion, CD4+ T cell count, CD8+ T cell count, calcitonin, procalcitonin, and troponin were significantly different between the severe group and the non-severe group (all P<0.05). Among the 71 patients, 4 (5.6%) patients were mild, 59 (83.1%) were normal, and 8 (11.3%) were severe or critical.

CONCLUSIONS

The aggregation phenomenon of COVID-19 is obvious. Fever and cough are the main clinical manifestations. White blood cells, neutrophils, and lymphocytes in the most patients in the early onset are normal. Most COVID-19 patients are light and ordinary type, with good prognosis.

Authors+Show Affiliations

Sixth Department of Infectious Diseases, Sixth People's Hospital of Zhengzhou, Zhengzhou 450015, China. 23617316@qq.com.Sixth Department of Infectious Diseases, Sixth People's Hospital of Zhengzhou, Zhengzhou 450015, China.Sixth Department of Infectious Diseases, Sixth People's Hospital of Zhengzhou, Zhengzhou 450015, China.Sixth Department of Infectious Diseases, Sixth People's Hospital of Zhengzhou, Zhengzhou 450015, China.Sixth Department of Infectious Diseases, Sixth People's Hospital of Zhengzhou, Zhengzhou 450015, China. zhqx666@163.com.

Pub Type(s)

Journal Article

Language

eng chi

PubMed ID

32879082

Citation

Xiao, Miaomiao, et al. "Clinical Characteristics of 71 Patients With Coronavirus Disease 2019." Zhong Nan Da Xue Xue Bao. Yi Xue Ban = Journal of Central South University. Medical Sciences, vol. 45, no. 7, 2020, pp. 790-796.
Xiao M, Hou M, Liu X, et al. Clinical characteristics of 71 patients with coronavirus disease 2019. Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2020;45(7):790-796.
Xiao, M., Hou, M., Liu, X., Li, Z., & Zhao, Q. (2020). Clinical characteristics of 71 patients with coronavirus disease 2019. Zhong Nan Da Xue Xue Bao. Yi Xue Ban = Journal of Central South University. Medical Sciences, 45(7), 790-796. https://doi.org/10.11817/j.issn.1672-7347.2020.200187
Xiao M, et al. Clinical Characteristics of 71 Patients With Coronavirus Disease 2019. Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2020 Jul 28;45(7):790-796. PubMed PMID: 32879082.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Clinical characteristics of 71 patients with coronavirus disease 2019. AU - Xiao,Miaomiao, AU - Hou,Mingjie, AU - Liu,Xuhui, AU - Li,Zhe, AU - Zhao,Qingxia, PY - 2020/9/4/entrez PY - 2020/9/4/pubmed PY - 2020/9/9/medline KW - clinical characteristics KW - coronavirus disease 2019 KW - cough KW - fever KW - pneumonia KW - severe acute respiratory syndrome coronavirus 2 SP - 790 EP - 796 JF - Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences JO - Zhong Nan Da Xue Xue Bao Yi Xue Ban VL - 45 IS - 7 N2 - OBJECTIVES: To analyze the clinical characteristics of 71 patients with coronavirus disease 2019 (COVID-19). METHODS: The general data, epidemiological data, laboratory tests, imaging examinations, and treatment of 71 patients with COVID-19 admitted to the Sixth People's Hospital of Zhengzhou from January 19, 2020 to March 3, 2020 were retrospectively analyzed. RESULTS: Of the 71 COVID-19 patients, the ages were 4-84 (41.29±15.21) years, 38 (53.5%) patients were male, 33 (46.5%) were female, and 52 (73.2%) were in 22 clusters. The main clinical manifestations were fever (78.9%), cough (64.8%), and sputum (38.0%). The fever was mainly low and moderate, with 49 patients (69.0%) at 37.3-39.0 ℃. Most of the leukocytes, neutrophils, and lymphocytes were normal, accounting for 47 (66.2%), 51 (71.8%), and 51 (71.8%) patients, respectively; a few of them were decreased, accounting for 21 (29.6%), 16 (22.5%), and 20 (28.2%) patients, respectively. There were 38 (53.5%) and 31 (43.7%) patients with the decreased CD4+ and CD8+ T cell counts, respectively. There were 41 (57.7%), 38 (53.5%), 32 (45.1%), 26(36.6%), 22 (31.0%), 20 (28.2%), 14 (19.7%), 14 (19.7%), and 9 (12.7%) patients with the increased levels of C-reactive protein, erythrocyte sedimentation rate, procalcitonin, fibrinogen,interleukin 6, lactate dehydrogenase,D-dimer,alanine aminotransferase, and aspartate aminotransferase, respectively. Of the 71 patients, the lung was involved in 60 (84.5%) patients, the double lung was involved in 47 (66.2%) patients, and the single lung was involved in 13 (18.3%) patients. The course of the disease was long, and the time from symptom onset to the second severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) nucleic acid negative transformation was (17.22±6.34) days.There were no significant differences in the incubation period (t=-0.453, P>0.05), the complicates (χ2=0.042, P>0.05), and the time from symptom onset to diagnosis (t=-1.330, P>0.05) in patients between the non-severe group and the severe group. The onset age, gender, SARS-CoV-2 nucleic acid negative time, lymphocyte count, D-dimer, C-reactive protein, total bilirubin, direct bilirubin, lactate dehydrogenase, calcium ion, CD4+ T cell count, CD8+ T cell count, calcitonin, procalcitonin, and troponin were significantly different between the severe group and the non-severe group (all P<0.05). Among the 71 patients, 4 (5.6%) patients were mild, 59 (83.1%) were normal, and 8 (11.3%) were severe or critical. CONCLUSIONS: The aggregation phenomenon of COVID-19 is obvious. Fever and cough are the main clinical manifestations. White blood cells, neutrophils, and lymphocytes in the most patients in the early onset are normal. Most COVID-19 patients are light and ordinary type, with good prognosis. SN - 1672-7347 UR - https://www.unboundmedicine.com/medline/citation/32879082/Clinical_characteristics_of_71_patients_with_coronavirus_disease_2019_ L2 - http://xbyxb.csu.edu.cn/xbwk/fileup/PDF/202007790.pdf DB - PRIME DP - Unbound Medicine ER -