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Quantifying the effect of remdesivir in rhesus macaques infected with SARS-CoV-2.
Virology. 2020 11; 550:61-69.V

Abstract

The world is in the midst of a pandemic caused by a novel coronavirus and is desperately searching for possible treatments. The antiviral remdesivir has shown some effectiveness against SARS-CoV-2 in vitro and in a recent animal study. We use data from a study of remdesivir in rhesus macaques to fit a viral kinetics model in an effort to determine the most appropriate mathematical descripton of the effect of remdesivir. We find statistically significant differences in the viral decay rate and use this to inform a possible mathematical formulation of the effect of remdesivir. Unfortunately, this model formulation suggests that the application of remdesivir will lengthen SARS-CoV-2 infections, putting into question its potential clinical benefit.

Authors+Show Affiliations

Department of Physics and Astronomy, Texas Christian University, Fort Worth, TX, USA. Electronic address: h.dobrovolny@tcu.edu.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

32882638

Citation

Dobrovolny, Hana M.. "Quantifying the Effect of Remdesivir in Rhesus Macaques Infected With SARS-CoV-2." Virology, vol. 550, 2020, pp. 61-69.
Dobrovolny HM. Quantifying the effect of remdesivir in rhesus macaques infected with SARS-CoV-2. Virology. 2020;550:61-69.
Dobrovolny, H. M. (2020). Quantifying the effect of remdesivir in rhesus macaques infected with SARS-CoV-2. Virology, 550, 61-69. https://doi.org/10.1016/j.virol.2020.07.015
Dobrovolny HM. Quantifying the Effect of Remdesivir in Rhesus Macaques Infected With SARS-CoV-2. Virology. 2020;550:61-69. PubMed PMID: 32882638.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Quantifying the effect of remdesivir in rhesus macaques infected with SARS-CoV-2. A1 - Dobrovolny,Hana M, Y1 - 2020/08/23/ PY - 2020/05/11/received PY - 2020/06/28/revised PY - 2020/07/21/accepted PY - 2020/9/4/pubmed PY - 2020/10/22/medline PY - 2020/9/4/entrez KW - Antiviral KW - COVID-19 KW - Coronavirus KW - Mathematical model KW - Treatment SP - 61 EP - 69 JF - Virology JO - Virology VL - 550 N2 - The world is in the midst of a pandemic caused by a novel coronavirus and is desperately searching for possible treatments. The antiviral remdesivir has shown some effectiveness against SARS-CoV-2 in vitro and in a recent animal study. We use data from a study of remdesivir in rhesus macaques to fit a viral kinetics model in an effort to determine the most appropriate mathematical descripton of the effect of remdesivir. We find statistically significant differences in the viral decay rate and use this to inform a possible mathematical formulation of the effect of remdesivir. Unfortunately, this model formulation suggests that the application of remdesivir will lengthen SARS-CoV-2 infections, putting into question its potential clinical benefit. SN - 1096-0341 UR - https://www.unboundmedicine.com/medline/citation/32882638/Quantifying_the_effect_of_remdesivir_in_rhesus_macaques_infected_with_SARS_CoV_2_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0042-6822(20)30142-2 DB - PRIME DP - Unbound Medicine ER -