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COVID-19 and Venous Thromboembolism: A Meta-analysis of Literature Studies.
Semin Thromb Hemost. 2020 Oct; 46(7):763-771.ST

Abstract

Coronavirus disease 2019 (COVID-19) may have a wide spectrum of clinical presentations, leading in some cases to a critical condition with poor long-term outcomes and residual disability requiring post-acute rehabilitation. A major concern in severe COVID-19 is represented by a concomitant prothrombotic state. However, contrasting data are available about the prevalence of venous thromboembolism (VTE), including deep vein thrombosis (DVT) and/or pulmonary embolism (PE). A detailed search on the association of COVID-19 with thromboembolic complications was conducted in the main electronic databases (PubMed, Web of Science, and Scopus) according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. The weighted mean prevalence (WMP) with 95% confidence interval (95% CI) was calculated with the random-effects model. Twenty studies enrolling 1,988 COVID-19 patients were included. The WMP of VTE was 31.3% (95% CI: 24.3-39.2%). The WMP of DVT was 19.8% (95% CI: 10.5-34.0%), whereas the WMP of PE was 18.9% (95% CI: 14.4-24.3%). Similar results were obtained when specifically analyzing studies on patients admitted to intensive care units and those on patients under antithrombotic prophylaxis. Regression models showed that an increasing age was associated with a higher prevalence of VTE (Z-score: 3.11, p = 0.001), DVT (Z-score: 2.33, p = 0.002), and PE (Z-score: 3.03, p = 0.002), while an increasing body mass index was associated with an increasing prevalence of PE (Z-score = 2.01, p = 0.04). Male sex did not impact the evaluated outcomes. The rate of thromboembolic complications in COVID-19 patients is definitely high. Considering the risk of fatal and disabling complications, adequate screening procedures and antithrombotic strategies should be implemented.

Authors+Show Affiliations

Department of Pharmacy, Federico II University, Naples, Italy.Istituti Clinici Scientifici Maugeri IRCCS, Pavia, Italy.Department of Clinical Medicine and Surgery, Federico II University, Naples, Italy.Department of Translational Medical Sciences, Federico II University, Naples, Italy.

Pub Type(s)

Journal Article
Meta-Analysis
Review

Language

eng

PubMed ID

32882719

Citation

Di Minno, Alessandro, et al. "COVID-19 and Venous Thromboembolism: a Meta-analysis of Literature Studies." Seminars in Thrombosis and Hemostasis, vol. 46, no. 7, 2020, pp. 763-771.
Di Minno A, Ambrosino P, Calcaterra I, et al. COVID-19 and Venous Thromboembolism: A Meta-analysis of Literature Studies. Semin Thromb Hemost. 2020;46(7):763-771.
Di Minno, A., Ambrosino, P., Calcaterra, I., & Di Minno, M. N. D. (2020). COVID-19 and Venous Thromboembolism: A Meta-analysis of Literature Studies. Seminars in Thrombosis and Hemostasis, 46(7), 763-771. https://doi.org/10.1055/s-0040-1715456
Di Minno A, et al. COVID-19 and Venous Thromboembolism: a Meta-analysis of Literature Studies. Semin Thromb Hemost. 2020;46(7):763-771. PubMed PMID: 32882719.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - COVID-19 and Venous Thromboembolism: A Meta-analysis of Literature Studies. AU - Di Minno,Alessandro, AU - Ambrosino,Pasquale, AU - Calcaterra,Ilenia, AU - Di Minno,Matteo Nicola Dario, Y1 - 2020/09/03/ PY - 2020/9/4/pubmed PY - 2020/11/3/medline PY - 2020/9/4/entrez SP - 763 EP - 771 JF - Seminars in thrombosis and hemostasis JO - Semin Thromb Hemost VL - 46 IS - 7 N2 - Coronavirus disease 2019 (COVID-19) may have a wide spectrum of clinical presentations, leading in some cases to a critical condition with poor long-term outcomes and residual disability requiring post-acute rehabilitation. A major concern in severe COVID-19 is represented by a concomitant prothrombotic state. However, contrasting data are available about the prevalence of venous thromboembolism (VTE), including deep vein thrombosis (DVT) and/or pulmonary embolism (PE). A detailed search on the association of COVID-19 with thromboembolic complications was conducted in the main electronic databases (PubMed, Web of Science, and Scopus) according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. The weighted mean prevalence (WMP) with 95% confidence interval (95% CI) was calculated with the random-effects model. Twenty studies enrolling 1,988 COVID-19 patients were included. The WMP of VTE was 31.3% (95% CI: 24.3-39.2%). The WMP of DVT was 19.8% (95% CI: 10.5-34.0%), whereas the WMP of PE was 18.9% (95% CI: 14.4-24.3%). Similar results were obtained when specifically analyzing studies on patients admitted to intensive care units and those on patients under antithrombotic prophylaxis. Regression models showed that an increasing age was associated with a higher prevalence of VTE (Z-score: 3.11, p = 0.001), DVT (Z-score: 2.33, p = 0.002), and PE (Z-score: 3.03, p = 0.002), while an increasing body mass index was associated with an increasing prevalence of PE (Z-score = 2.01, p = 0.04). Male sex did not impact the evaluated outcomes. The rate of thromboembolic complications in COVID-19 patients is definitely high. Considering the risk of fatal and disabling complications, adequate screening procedures and antithrombotic strategies should be implemented. SN - 1098-9064 UR - https://www.unboundmedicine.com/medline/citation/32882719/COVID_19_and_Venous_Thromboembolism:_A_Meta_analysis_of_Literature_Studies_ L2 - http://www.thieme-connect.com/DOI/DOI?10.1055/s-0040-1715456 DB - PRIME DP - Unbound Medicine ER -