Tags

Type your tag names separated by a space and hit enter

Natural Flavonoids as Potential Angiotensin-Converting Enzyme 2 Inhibitors for Anti-SARS-CoV-2.
Molecules. 2020 Sep 01; 25(17)M

Abstract

Over the years, coronaviruses (CoV) have posed a severe public health threat, causing an increase in mortality and morbidity rates throughout the world. The recent outbreak of a novel coronavirus, named severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) caused the current Coronavirus Disease 2019 (COVID-19) pandemic that affected more than 215 countries with over 23 million cases and 800,000 deaths as of today. The situation is critical, especially with the absence of specific medicines or vaccines; hence, efforts toward the development of anti-COVID-19 medicines are being intensively undertaken. One of the potential therapeutic targets of anti-COVID-19 drugs is the angiotensin-converting enzyme 2 (ACE2). ACE2 was identified as a key functional receptor for CoV associated with COVID-19. ACE2, which is located on the surface of the host cells, binds effectively to the spike protein of CoV, thus enabling the virus to infect the epithelial cells of the host. Previous studies showed that certain flavonoids exhibit angiotensin-converting enzyme inhibition activity, which plays a crucial role in the regulation of arterial blood pressure. Thus, it is being postulated that these flavonoids might also interact with ACE2. This postulation might be of interest because these compounds also show antiviral activity in vitro. This article summarizes the natural flavonoids with potential efficacy against COVID-19 through ACE2 receptor inhibition.

Links

PMC Free PDF

Authors+Show Affiliations

Muchtaridi M
Department of Pharmaceutical Analysis and Medicinal Chemistry, Faculty of Pharmacy, Universitas Padjadjaran, Jl Raya 21.5, Bandung-Sumedang 45363, Indonesia.
Fauzi M
Department of Pharmaceutical Analysis and Medicinal Chemistry, Faculty of Pharmacy, Universitas Padjadjaran, Jl Raya 21.5, Bandung-Sumedang 45363, Indonesia.
Khairul Ikram NK
Institute of Biological Sciences, Faculty of Science, Universiti Malaya, Kuala Lumpur 50603, Malaysia. Centre for Research in Biotechnology for Agriculture (CEBAR), Universiti Malaya, Kuala Lumpur 50603, Malaysia.
Mohd Gazzali A
Department of Pharmaceutical Technology, School of Pharmaceutical Sciences, Universiti Sains Malaysia, Gelugor 11800, Penang, Malaysia.
Wahab HA
Pharmaceutical Design and Simulation Laboratory, School of Pharmaceutical Sciences, Universiti Sains Malaysia, Gelugor 11800, Penang, Malaysia.

MeSH

Angiotensin-Converting Enzyme 2Angiotensin-Converting Enzyme InhibitorsAntiviral AgentsBetacoronavirusBiological ProductsCOVID-19Coronavirus InfectionsDisease SusceptibilityFlavonoidsHumansLife Cycle StagesModels, MolecularPandemicsPeptidyl-Dipeptidase APneumonia, ViralPopulation SurveillanceSARS-CoV-2Structure-Activity Relationship

Pub Type(s)

Journal Article
Meta-Analysis
Review

Language

eng

PubMed ID

32882868

Citation

Muchtaridi, Muchtaridi, et al. "Natural Flavonoids as Potential Angiotensin-Converting Enzyme 2 Inhibitors for Anti-SARS-CoV-2." Molecules (Basel, Switzerland), vol. 25, no. 17, 2020.
Muchtaridi M, Fauzi M, Khairul Ikram NK, et al. Natural Flavonoids as Potential Angiotensin-Converting Enzyme 2 Inhibitors for Anti-SARS-CoV-2. Molecules. 2020;25(17).
Muchtaridi, M., Fauzi, M., Khairul Ikram, N. K., Mohd Gazzali, A., & Wahab, H. A. (2020). Natural Flavonoids as Potential Angiotensin-Converting Enzyme 2 Inhibitors for Anti-SARS-CoV-2. Molecules (Basel, Switzerland), 25(17). https://doi.org/10.3390/molecules25173980
Muchtaridi M, et al. Natural Flavonoids as Potential Angiotensin-Converting Enzyme 2 Inhibitors for Anti-SARS-CoV-2. Molecules. 2020 Sep 1;25(17) PubMed PMID: 32882868.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Natural Flavonoids as Potential Angiotensin-Converting Enzyme 2 Inhibitors for Anti-SARS-CoV-2. AU - Muchtaridi,Muchtaridi, AU - Fauzi,M, AU - Khairul Ikram,Nur Kusaira, AU - Mohd Gazzali,Amirah, AU - Wahab,Habibah A, Y1 - 2020/09/01/ PY - 2020/8/3/received PY - 2020/8/25/revised PY - 2020/8/26/accepted PY - 2020/9/5/entrez PY - 2020/9/5/pubmed PY - 2020/9/12/medline KW - ACE2 KW - COVID-19 KW - coronavirus KW - flavonoid JF - Molecules (Basel, Switzerland) JO - Molecules VL - 25 IS - 17 N2 - Over the years, coronaviruses (CoV) have posed a severe public health threat, causing an increase in mortality and morbidity rates throughout the world. The recent outbreak of a novel coronavirus, named severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) caused the current Coronavirus Disease 2019 (COVID-19) pandemic that affected more than 215 countries with over 23 million cases and 800,000 deaths as of today. The situation is critical, especially with the absence of specific medicines or vaccines; hence, efforts toward the development of anti-COVID-19 medicines are being intensively undertaken. One of the potential therapeutic targets of anti-COVID-19 drugs is the angiotensin-converting enzyme 2 (ACE2). ACE2 was identified as a key functional receptor for CoV associated with COVID-19. ACE2, which is located on the surface of the host cells, binds effectively to the spike protein of CoV, thus enabling the virus to infect the epithelial cells of the host. Previous studies showed that certain flavonoids exhibit angiotensin-converting enzyme inhibition activity, which plays a crucial role in the regulation of arterial blood pressure. Thus, it is being postulated that these flavonoids might also interact with ACE2. This postulation might be of interest because these compounds also show antiviral activity in vitro. This article summarizes the natural flavonoids with potential efficacy against COVID-19 through ACE2 receptor inhibition. SN - 1420-3049 UR - https://www.unboundmedicine.com/medline/citation/32882868/Natural_Flavonoids_as_Potential_Angiotensin_Converting_Enzyme_2_Inhibitors_for_Anti_SARS_CoV_2_ DB - PRIME DP - Unbound Medicine ER -