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Bronchoconstrictor and antibronchoconstrictor properties of inhaled prostacyclin in asthma.
J Appl Physiol (1985). 1988 Apr; 64(4):1567-74.JA

Abstract

Prostacyclin (PGI2) is generated in appreciable amounts during allergic reactions in human lung tissue. To define its activity on human airways we have studied the effects of doubling concentrations of inhaled PGI2 and its hydrolysis product 6-oxoprostaglandin F1 alpha (6-oxo-PGF1 alpha) on specific airway conductance (sGaw), maximum expiratory flow at 30% vital capacity (Vmax30), forced expiratory volume in 1 s (FEV1), and static lung volumes in subjects with mild allergic asthma. In a second study the effect of inhaled PGI2 on bronchoconstriction provoked by increasing concentrations of inhaled prostaglandin (PG) D2 and methacholine was observed. Inhalation of PGI2 up to a concentration of 500 micrograms/ml had no significant effect on sGaw but produced a concentration-related decrease in FEV1 and Vmax30 in all subjects. In two of four subjects inhalation of PGI2 also increased residual volume and decreased vital capacity but had no effect on total lung capacity. PGI2, but not 6-oxo-PGF1 alpha, protected against bronchoconstriction provoked by either PGD2 or methacholine whether airway caliber was measured as sGaw, FEV1, or Vmax30. The apparent disparity between the bronchoconstrictor and antibronchoconstrictor effects of PGI2 might be explained by its potent vasodilator effect in causing airway narrowing through mucosal engorgement and reducing the spasmogenic effects of other inhaled mediators by increasing their clearance from the airways.

Authors+Show Affiliations

Medicine 1 and Clinical Pharmacology, Southampton General Hospital, United Kingdom.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

3288608

Citation

Hardy, C C., et al. "Bronchoconstrictor and Antibronchoconstrictor Properties of Inhaled Prostacyclin in Asthma." Journal of Applied Physiology (Bethesda, Md. : 1985), vol. 64, no. 4, 1988, pp. 1567-74.
Hardy CC, Bradding P, Robinson C, et al. Bronchoconstrictor and antibronchoconstrictor properties of inhaled prostacyclin in asthma. J Appl Physiol (1985). 1988;64(4):1567-74.
Hardy, C. C., Bradding, P., Robinson, C., & Holgate, S. T. (1988). Bronchoconstrictor and antibronchoconstrictor properties of inhaled prostacyclin in asthma. Journal of Applied Physiology (Bethesda, Md. : 1985), 64(4), 1567-74.
Hardy CC, et al. Bronchoconstrictor and Antibronchoconstrictor Properties of Inhaled Prostacyclin in Asthma. J Appl Physiol (1985). 1988;64(4):1567-74. PubMed PMID: 3288608.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Bronchoconstrictor and antibronchoconstrictor properties of inhaled prostacyclin in asthma. AU - Hardy,C C, AU - Bradding,P, AU - Robinson,C, AU - Holgate,S T, PY - 1988/4/1/pubmed PY - 1988/4/1/medline PY - 1988/4/1/entrez SP - 1567 EP - 74 JF - Journal of applied physiology (Bethesda, Md. : 1985) JO - J Appl Physiol (1985) VL - 64 IS - 4 N2 - Prostacyclin (PGI2) is generated in appreciable amounts during allergic reactions in human lung tissue. To define its activity on human airways we have studied the effects of doubling concentrations of inhaled PGI2 and its hydrolysis product 6-oxoprostaglandin F1 alpha (6-oxo-PGF1 alpha) on specific airway conductance (sGaw), maximum expiratory flow at 30% vital capacity (Vmax30), forced expiratory volume in 1 s (FEV1), and static lung volumes in subjects with mild allergic asthma. In a second study the effect of inhaled PGI2 on bronchoconstriction provoked by increasing concentrations of inhaled prostaglandin (PG) D2 and methacholine was observed. Inhalation of PGI2 up to a concentration of 500 micrograms/ml had no significant effect on sGaw but produced a concentration-related decrease in FEV1 and Vmax30 in all subjects. In two of four subjects inhalation of PGI2 also increased residual volume and decreased vital capacity but had no effect on total lung capacity. PGI2, but not 6-oxo-PGF1 alpha, protected against bronchoconstriction provoked by either PGD2 or methacholine whether airway caliber was measured as sGaw, FEV1, or Vmax30. The apparent disparity between the bronchoconstrictor and antibronchoconstrictor effects of PGI2 might be explained by its potent vasodilator effect in causing airway narrowing through mucosal engorgement and reducing the spasmogenic effects of other inhaled mediators by increasing their clearance from the airways. SN - 8750-7587 UR - https://www.unboundmedicine.com/medline/citation/3288608/Bronchoconstrictor_and_antibronchoconstrictor_properties_of_inhaled_prostacyclin_in_asthma_ L2 - https://journals.physiology.org/doi/10.1152/jappl.1988.64.4.1567?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -