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Phenotypical and functional alteration of unconventional T cells in severe COVID-19 patients.
J Exp Med. 2020 12 07; 217(12)JE

Abstract

COVID-19 includes lung infection ranging from mild pneumonia to life-threatening acute respiratory distress syndrome (ARDS). Dysregulated host immune response in the lung is a key feature in ARDS pathophysiology. However, cellular actors involved in COVID-19-driven ARDS are poorly understood. Here, in blood and airways of severe COVID-19 patients, we serially analyzed unconventional T cells, a heterogeneous class of T lymphocytes (MAIT, γδT, and iNKT cells) with potent antimicrobial and regulatory functions. Circulating unconventional T cells of COVID-19 patients presented with a profound and persistent phenotypic alteration. In the airways, highly activated unconventional T cells were detected, suggesting a potential contribution in the regulation of local inflammation. Finally, expression of the CD69 activation marker on blood iNKT and MAIT cells of COVID-19 patients on admission was predictive of clinical course and disease severity. Thus, COVID-19 patients present with an altered unconventional T cell biology, and further investigations will be required to precisely assess their functions during SARS-CoV-2-driven ARDS.

Links

Publisher Full Text
ncbi.nlm.nih.gov
rupress.org
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Authors+Show Affiliations

Jouan Y
Institut national de la santé et de la recherche médicale, Centre d'Etude des Pathologies Respiratoires, UMR 1100, Tours, France. Université de Tours, Faculté de Médecine de Tours, Tours, France. Service de Médecine Intensive et Réanimation, Centre Hospitalier Régional Universitaire, Tours, France. Service de chirurgie cardiaque et de réanimation chirurgicale cardio-vasculaire, Centre Hospitalier Régional Universitaire, Tours, France.
Guillon A
Institut national de la santé et de la recherche médicale, Centre d'Etude des Pathologies Respiratoires, UMR 1100, Tours, France. Université de Tours, Faculté de Médecine de Tours, Tours, France. Service de Médecine Intensive et Réanimation, Centre Hospitalier Régional Universitaire, Tours, France.
Gonzalez L
Institut national de la santé et de la recherche médicale, Centre d'Etude des Pathologies Respiratoires, UMR 1100, Tours, France. Université de Tours, Faculté de Médecine de Tours, Tours, France.
Perez Y
Institut national de la santé et de la recherche médicale, Centre d'Etude des Pathologies Respiratoires, UMR 1100, Tours, France. Université de Tours, Faculté de Médecine de Tours, Tours, France. Service de Médecine Intensive et Réanimation, Centre Hospitalier Régional Universitaire, Tours, France.
Boisseau C
Institut national de la santé et de la recherche médicale, Centre d'Etude des Pathologies Respiratoires, UMR 1100, Tours, France. Université de Tours, Faculté de Médecine de Tours, Tours, France.
Ehrmann S
Institut national de la santé et de la recherche médicale, Centre d'Etude des Pathologies Respiratoires, UMR 1100, Tours, France. Université de Tours, Faculté de Médecine de Tours, Tours, France. Service de Médecine Intensive et Réanimation, Centre Hospitalier Régional Universitaire, Tours, France.
Ferreira M
Université de Tours, Faculté de Médecine de Tours, Tours, France. Service de pneumologie, Centre Hospitalier Régional Universitaire, Tours, France.
Daix T
Intensive Care Unit, Dupuytren Teaching Hospital, Limoges, France. Institut national de la santé et de la recherche médicale CIC1435, Dupuytren Teaching Hospital, Limoges, France. Institut national de la santé et de la recherche médicale UMR 1092, University of Limoges, Limoges, France.
Jeannet R
Intensive Care Unit, Dupuytren Teaching Hospital, Limoges, France. Institut national de la santé et de la recherche médicale CIC1435, Dupuytren Teaching Hospital, Limoges, France. Institut national de la santé et de la recherche médicale UMR 1092, University of Limoges, Limoges, France.
François B
Intensive Care Unit, Dupuytren Teaching Hospital, Limoges, France. Institut national de la santé et de la recherche médicale CIC1435, Dupuytren Teaching Hospital, Limoges, France. Institut national de la santé et de la recherche médicale UMR 1092, University of Limoges, Limoges, France.
Dequin PF
Institut national de la santé et de la recherche médicale, Centre d'Etude des Pathologies Respiratoires, UMR 1100, Tours, France. Université de Tours, Faculté de Médecine de Tours, Tours, France. Service de Médecine Intensive et Réanimation, Centre Hospitalier Régional Universitaire, Tours, France.
Si-Tahar M
Institut national de la santé et de la recherche médicale, Centre d'Etude des Pathologies Respiratoires, UMR 1100, Tours, France. Université de Tours, Faculté de Médecine de Tours, Tours, France.
Baranek T
Institut national de la santé et de la recherche médicale, Centre d'Etude des Pathologies Respiratoires, UMR 1100, Tours, France. Université de Tours, Faculté de Médecine de Tours, Tours, France.
Paget C
Institut national de la santé et de la recherche médicale, Centre d'Etude des Pathologies Respiratoires, UMR 1100, Tours, France. Université de Tours, Faculté de Médecine de Tours, Tours, France.

MeSH

AgedAntigens, CDAntigens, Differentiation, T-LymphocyteBetacoronavirusCOVID-19Cells, CulturedCoronavirus InfectionsCytokinesFemaleHumansInflammationLectins, C-TypeMaleMiddle AgedMucosal-Associated Invariant T CellsNatural Killer T-CellsPandemicsPhenotypePneumonia, ViralPrognosisProspective StudiesReceptors, Antigen, T-Cell, gamma-deltaRespiratory Distress SyndromeSARS-CoV-2Severity of Illness Index

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

32886755

Citation

Jouan, Youenn, et al. "Phenotypical and Functional Alteration of Unconventional T Cells in Severe COVID-19 Patients." The Journal of Experimental Medicine, vol. 217, no. 12, 2020.
Jouan Y, Guillon A, Gonzalez L, et al. Phenotypical and functional alteration of unconventional T cells in severe COVID-19 patients. J Exp Med. 2020;217(12).
Jouan, Y., Guillon, A., Gonzalez, L., Perez, Y., Boisseau, C., Ehrmann, S., Ferreira, M., Daix, T., Jeannet, R., François, B., Dequin, P. F., Si-Tahar, M., Baranek, T., & Paget, C. (2020). Phenotypical and functional alteration of unconventional T cells in severe COVID-19 patients. The Journal of Experimental Medicine, 217(12). https://doi.org/10.1084/jem.20200872
Jouan Y, et al. Phenotypical and Functional Alteration of Unconventional T Cells in Severe COVID-19 Patients. J Exp Med. 2020 12 7;217(12) PubMed PMID: 32886755.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Phenotypical and functional alteration of unconventional T cells in severe COVID-19 patients. AU - Jouan,Youenn, AU - Guillon,Antoine, AU - Gonzalez,Loïc, AU - Perez,Yonatan, AU - Boisseau,Chloé, AU - Ehrmann,Stephan, AU - Ferreira,Marion, AU - Daix,Thomas, AU - Jeannet,Robin, AU - François,Bruno, AU - Dequin,Pierre-François, AU - Si-Tahar,Mustapha, AU - Baranek,Thomas, AU - Paget,Christophe, PY - 2020/05/05/received PY - 2020/06/24/revised PY - 2020/08/12/accepted PY - 2020/9/4/entrez PY - 2020/9/5/pubmed PY - 2020/9/22/medline JF - The Journal of experimental medicine JO - J Exp Med VL - 217 IS - 12 N2 - COVID-19 includes lung infection ranging from mild pneumonia to life-threatening acute respiratory distress syndrome (ARDS). Dysregulated host immune response in the lung is a key feature in ARDS pathophysiology. However, cellular actors involved in COVID-19-driven ARDS are poorly understood. Here, in blood and airways of severe COVID-19 patients, we serially analyzed unconventional T cells, a heterogeneous class of T lymphocytes (MAIT, γδT, and iNKT cells) with potent antimicrobial and regulatory functions. Circulating unconventional T cells of COVID-19 patients presented with a profound and persistent phenotypic alteration. In the airways, highly activated unconventional T cells were detected, suggesting a potential contribution in the regulation of local inflammation. Finally, expression of the CD69 activation marker on blood iNKT and MAIT cells of COVID-19 patients on admission was predictive of clinical course and disease severity. Thus, COVID-19 patients present with an altered unconventional T cell biology, and further investigations will be required to precisely assess their functions during SARS-CoV-2-driven ARDS. SN - 1540-9538 UR - https://www.unboundmedicine.com/medline/citation/32886755/Phenotypical_and_functional_alteration_of_unconventional_T_cells_in_severe_COVID_19_patients_ L2 - https://rupress.org/jem/article-lookup/doi/10.1084/jem.20200872 DB - PRIME DP - Unbound Medicine ER -