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Immunological considerations for COVID-19 vaccine strategies.
Nat Rev Immunol. 2020 10; 20(10):615-632.NR

Abstract

The coronavirus disease 2019 (COVID-19) pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the most formidable challenge to humanity in a century. It is widely believed that prepandemic normalcy will never return until a safe and effective vaccine strategy becomes available and a global vaccination programme is implemented successfully. Here, we discuss the immunological principles that need to be taken into consideration in the development of COVID-19 vaccine strategies. On the basis of these principles, we examine the current COVID-19 vaccine candidates, their strengths and potential shortfalls, and make inferences about their chances of success. Finally, we discuss the scientific and practical challenges that will be faced in the process of developing a successful vaccine and the ways in which COVID-19 vaccine strategies may evolve over the next few years.

Authors+Show Affiliations

McMaster Immunology Research Centre, McMaster University, Hamilton, ON, Canada. Department of Pathology and Molecular Medicine, McMaster University, Hamilton, ON, Canada. Michael G. DeGroote Institute for Infectious Disease Research, McMaster University, Hamilton, ON, Canada.McMaster Immunology Research Centre, McMaster University, Hamilton, ON, Canada. Department of Pathology and Molecular Medicine, McMaster University, Hamilton, ON, Canada. Michael G. DeGroote Institute for Infectious Disease Research, McMaster University, Hamilton, ON, Canada.Department of Pathology and Molecular Medicine, McMaster University, Hamilton, ON, Canada. Michael G. DeGroote Institute for Infectious Disease Research, McMaster University, Hamilton, ON, Canada.McMaster Immunology Research Centre, McMaster University, Hamilton, ON, Canada. Michael G. DeGroote Institute for Infectious Disease Research, McMaster University, Hamilton, ON, Canada. Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, ON, Canada.McMaster Immunology Research Centre, McMaster University, Hamilton, ON, Canada. blichty@mac.com. Department of Pathology and Molecular Medicine, McMaster University, Hamilton, ON, Canada. blichty@mac.com.McMaster Immunology Research Centre, McMaster University, Hamilton, ON, Canada. xingz@mcmaster.ca. Department of Pathology and Molecular Medicine, McMaster University, Hamilton, ON, Canada. xingz@mcmaster.ca. Michael G. DeGroote Institute for Infectious Disease Research, McMaster University, Hamilton, ON, Canada. xingz@mcmaster.ca.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

32887954

Citation

Jeyanathan, Mangalakumari, et al. "Immunological Considerations for COVID-19 Vaccine Strategies." Nature Reviews. Immunology, vol. 20, no. 10, 2020, pp. 615-632.
Jeyanathan M, Afkhami S, Smaill F, et al. Immunological considerations for COVID-19 vaccine strategies. Nat Rev Immunol. 2020;20(10):615-632.
Jeyanathan, M., Afkhami, S., Smaill, F., Miller, M. S., Lichty, B. D., & Xing, Z. (2020). Immunological considerations for COVID-19 vaccine strategies. Nature Reviews. Immunology, 20(10), 615-632. https://doi.org/10.1038/s41577-020-00434-6
Jeyanathan M, et al. Immunological Considerations for COVID-19 Vaccine Strategies. Nat Rev Immunol. 2020;20(10):615-632. PubMed PMID: 32887954.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Immunological considerations for COVID-19 vaccine strategies. AU - Jeyanathan,Mangalakumari, AU - Afkhami,Sam, AU - Smaill,Fiona, AU - Miller,Matthew S, AU - Lichty,Brian D, AU - Xing,Zhou, Y1 - 2020/09/04/ PY - 2020/08/13/accepted PY - 2020/9/6/pubmed PY - 2020/10/7/medline PY - 2020/9/5/entrez SP - 615 EP - 632 JF - Nature reviews. Immunology JO - Nat Rev Immunol VL - 20 IS - 10 N2 - The coronavirus disease 2019 (COVID-19) pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the most formidable challenge to humanity in a century. It is widely believed that prepandemic normalcy will never return until a safe and effective vaccine strategy becomes available and a global vaccination programme is implemented successfully. Here, we discuss the immunological principles that need to be taken into consideration in the development of COVID-19 vaccine strategies. On the basis of these principles, we examine the current COVID-19 vaccine candidates, their strengths and potential shortfalls, and make inferences about their chances of success. Finally, we discuss the scientific and practical challenges that will be faced in the process of developing a successful vaccine and the ways in which COVID-19 vaccine strategies may evolve over the next few years. SN - 1474-1741 UR - https://www.unboundmedicine.com/medline/citation/32887954/Immunological_considerations_for_COVID_19_vaccine_strategies_ L2 - https://doi.org/10.1038/s41577-020-00434-6 DB - PRIME DP - Unbound Medicine ER -