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Clinical Analysis of Neonates Born to Mothers with or without COVID-19: A Retrospective Analysis of 48 Cases from Two Neonatal Intensive Care Units in Hubei Province.
Am J Perinatol. 2020 11; 37(13):1317-1323.AJ

Abstract

OBJECTIVE

The perinatal consequences of neonates born to severe acute respiratory syndrome-associated coronavirus-2 (SARS-CoV-2) infected mothers are uncertain. This study aimed to compare the differences in clinical manifestation, laboratory results, and outcomes of neonates born to mothers with or without coronavirus disease 2019 (COVID-19).

STUDY DESIGN

A total of 48 neonates were admitted to Tongji Hospital and HuangShi Maternal and Child Healthcare Hospital from January 17 to March 4, 2020. The neonates were divided into three groups according to the mothers' conditions: neonates born to mothers with confirmed COVID-19, neonates born to mothers with clinically diagnosed COVID-19, and neonates born to mothers without COVID-19. The clinical data of mothers and infants in the three groups were collected, compared, and analyzed.

RESULTS

The deliveries occurred in a negative pressure isolation room, and the neonates were separated from their mothers immediately after birth for further observation and treatment. None of the neonates showed any signs of fever, cough, dyspnea, or diarrhea. SARS-CoV-2 reverse transcriptase-polymerase chain reaction of the throat swab and feces samples from the neonates in all three groups was negative. No differences were detected in the whole blood cell, lymphocytes, platelet, and liver and renal function among the three groups. All mothers and their infants showed satisfactory outcomes, including a 28-week preterm infant.

CONCLUSION

The clinical manifestations, radiological, and biochemical results did not show any difference between the three groups. No evidence of vertical transmission was found in this study whether the pregnant women developed coronavirus infection in the third (14 cases) or second trimester (1 case).

KEY POINTS

· Characteristics of neonates born to mothers with and without COVID-19 have been compared.. · All the 48 cases presented in the study had good outcomes.. · A 28-week preterm born to COVID-19 mother presented to be clear of SARS-COV-2 infection..

Authors+Show Affiliations

Department of Pediatrics, Huazhong University of Science and Technology, Tongji Hospital, Tongji Medical College, Wuhan, Hubei, China.Department of Neonatology, HuangShi Maternal and Child Healthcare Hospital, Huangshi, Hubei, China.Department of Pediatrics, Huazhong University of Science and Technology, Tongji Hospital, Tongji Medical College, Wuhan, Hubei, China.Department of Pediatrics, Huazhong University of Science and Technology, Tongji Hospital, Tongji Medical College, Wuhan, Hubei, China.Department of Pediatrics, Huazhong University of Science and Technology, Tongji Hospital, Tongji Medical College, Wuhan, Hubei, China.Department of Pediatrics, Huazhong University of Science and Technology, Tongji Hospital, Tongji Medical College, Wuhan, Hubei, China.Department of Pediatrics, Huazhong University of Science and Technology, Tongji Hospital, Tongji Medical College, Wuhan, Hubei, China.Department of Pediatrics, Huazhong University of Science and Technology, Tongji Hospital, Tongji Medical College, Wuhan, Hubei, China.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

32892325

Citation

Liu, Wei, et al. "Clinical Analysis of Neonates Born to Mothers With or Without COVID-19: a Retrospective Analysis of 48 Cases From Two Neonatal Intensive Care Units in Hubei Province." American Journal of Perinatology, vol. 37, no. 13, 2020, pp. 1317-1323.
Liu W, Cheng H, Wang J, et al. Clinical Analysis of Neonates Born to Mothers with or without COVID-19: A Retrospective Analysis of 48 Cases from Two Neonatal Intensive Care Units in Hubei Province. Am J Perinatol. 2020;37(13):1317-1323.
Liu, W., Cheng, H., Wang, J., Ding, L., Zhou, Z., Liu, S., Chang, L., & Rong, Z. (2020). Clinical Analysis of Neonates Born to Mothers with or without COVID-19: A Retrospective Analysis of 48 Cases from Two Neonatal Intensive Care Units in Hubei Province. American Journal of Perinatology, 37(13), 1317-1323. https://doi.org/10.1055/s-0040-1716505
Liu W, et al. Clinical Analysis of Neonates Born to Mothers With or Without COVID-19: a Retrospective Analysis of 48 Cases From Two Neonatal Intensive Care Units in Hubei Province. Am J Perinatol. 2020;37(13):1317-1323. PubMed PMID: 32892325.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Clinical Analysis of Neonates Born to Mothers with or without COVID-19: A Retrospective Analysis of 48 Cases from Two Neonatal Intensive Care Units in Hubei Province. AU - Liu,Wei, AU - Cheng,Hongbin, AU - Wang,Jing, AU - Ding,Lingli, AU - Zhou,Zhaoxian, AU - Liu,Siying, AU - Chang,Liwen, AU - Rong,Zhihui, Y1 - 2020/09/06/ PY - 2020/9/7/pubmed PY - 2020/10/29/medline PY - 2020/9/6/entrez SP - 1317 EP - 1323 JF - American journal of perinatology JO - Am J Perinatol VL - 37 IS - 13 N2 - OBJECTIVE: The perinatal consequences of neonates born to severe acute respiratory syndrome-associated coronavirus-2 (SARS-CoV-2) infected mothers are uncertain. This study aimed to compare the differences in clinical manifestation, laboratory results, and outcomes of neonates born to mothers with or without coronavirus disease 2019 (COVID-19). STUDY DESIGN: A total of 48 neonates were admitted to Tongji Hospital and HuangShi Maternal and Child Healthcare Hospital from January 17 to March 4, 2020. The neonates were divided into three groups according to the mothers' conditions: neonates born to mothers with confirmed COVID-19, neonates born to mothers with clinically diagnosed COVID-19, and neonates born to mothers without COVID-19. The clinical data of mothers and infants in the three groups were collected, compared, and analyzed. RESULTS: The deliveries occurred in a negative pressure isolation room, and the neonates were separated from their mothers immediately after birth for further observation and treatment. None of the neonates showed any signs of fever, cough, dyspnea, or diarrhea. SARS-CoV-2 reverse transcriptase-polymerase chain reaction of the throat swab and feces samples from the neonates in all three groups was negative. No differences were detected in the whole blood cell, lymphocytes, platelet, and liver and renal function among the three groups. All mothers and their infants showed satisfactory outcomes, including a 28-week preterm infant. CONCLUSION: The clinical manifestations, radiological, and biochemical results did not show any difference between the three groups. No evidence of vertical transmission was found in this study whether the pregnant women developed coronavirus infection in the third (14 cases) or second trimester (1 case). KEY POINTS: · Characteristics of neonates born to mothers with and without COVID-19 have been compared.. · All the 48 cases presented in the study had good outcomes.. · A 28-week preterm born to COVID-19 mother presented to be clear of SARS-COV-2 infection.. SN - 1098-8785 UR - https://www.unboundmedicine.com/medline/citation/32892325/Clinical_Analysis_of_Neonates_Born_to_Mothers_with_or_without_COVID_19:_A_Retrospective_Analysis_of_48_Cases_from_Two_Neonatal_Intensive_Care_Units_in_Hubei_Province_ L2 - http://www.thieme-connect.com/DOI/DOI?10.1055/s-0040-1716505 DB - PRIME DP - Unbound Medicine ER -