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Where Did SARS-CoV-2 Come From?
Mol Biol Evol. 2020 09 01; 37(9):2463-2464.MB

Abstract

Identifying the origin of SARS-CoV-2, the etiological agent of the current COVID-19 pandemic, may help us to avoid future epidemics of coronavirus and other zoonoses. Several theories about the zoonotic origin of SARS-CoV-2 have recently been proposed. Although Betacoronavirus found in Rhinolophus bats from China have been broadly implicated, their genetic dissimilarity to SARS-CoV-2 is so high that they are highly unlikely to be its direct ancestors. Thus, an intermediary host is suspected to link bat to human coronaviruses. Based on genomic CpG dinucleotide patterns in different coronaviruses from different hosts, it was suggested that SARS-CoV-2 might have evolved in a canid gastrointestinal tract prior to transmission to humans. However, similar CpG patterns are now reported in coronaviruses from other hosts, including bats themselves and pangolins. Therefore, reduced genomic CpG alone is not a highly predictive biomarker, suggesting a need for additional biomarkers to reveal intermediate hosts or tissues. The hunt for the zoonotic origin of SARS-CoV-2 continues.

Authors+Show Affiliations

Theroretical Biology and Biophysics group, Los Alamos National Laboratory, Los Alamos, NM.Institute for Genomics and Evolutionary Medicine, Temple University, Philadelphia, PA. Center for Excellence in Genome Medicine and Research, King Abdulaziz University, Jeddah, Saudi Arabia.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

32893295

Citation

Leitner, Thomas, and Sudhir Kumar. "Where Did SARS-CoV-2 Come From?" Molecular Biology and Evolution, vol. 37, no. 9, 2020, pp. 2463-2464.
Leitner T, Kumar S. Where Did SARS-CoV-2 Come From? Mol Biol Evol. 2020;37(9):2463-2464.
Leitner, T., & Kumar, S. (2020). Where Did SARS-CoV-2 Come From? Molecular Biology and Evolution, 37(9), 2463-2464. https://doi.org/10.1093/molbev/msaa162
Leitner T, Kumar S. Where Did SARS-CoV-2 Come From. Mol Biol Evol. 2020 09 1;37(9):2463-2464. PubMed PMID: 32893295.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Where Did SARS-CoV-2 Come From? AU - Leitner,Thomas, AU - Kumar,Sudhir, PY - 2020/9/7/entrez PY - 2020/9/8/pubmed PY - 2020/9/17/medline KW - SARS-CoV-2 KW - evolution KW - origins KW - pandemic SP - 2463 EP - 2464 JF - Molecular biology and evolution JO - Mol Biol Evol VL - 37 IS - 9 N2 - Identifying the origin of SARS-CoV-2, the etiological agent of the current COVID-19 pandemic, may help us to avoid future epidemics of coronavirus and other zoonoses. Several theories about the zoonotic origin of SARS-CoV-2 have recently been proposed. Although Betacoronavirus found in Rhinolophus bats from China have been broadly implicated, their genetic dissimilarity to SARS-CoV-2 is so high that they are highly unlikely to be its direct ancestors. Thus, an intermediary host is suspected to link bat to human coronaviruses. Based on genomic CpG dinucleotide patterns in different coronaviruses from different hosts, it was suggested that SARS-CoV-2 might have evolved in a canid gastrointestinal tract prior to transmission to humans. However, similar CpG patterns are now reported in coronaviruses from other hosts, including bats themselves and pangolins. Therefore, reduced genomic CpG alone is not a highly predictive biomarker, suggesting a need for additional biomarkers to reveal intermediate hosts or tissues. The hunt for the zoonotic origin of SARS-CoV-2 continues. SN - 1537-1719 UR - https://www.unboundmedicine.com/medline/citation/32893295/Where_Did_SARS_CoV_2_Come_From L2 - https://academic.oup.com/mbe/article-lookup/doi/10.1093/molbev/msaa162 DB - PRIME DP - Unbound Medicine ER -