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Anosmia and Ageusia as Predictive Signs of COVID-19 in Healthcare Workers in Italy: A Prospective Case-Control Study.
J Clin Med. 2020 Sep 04; 9(9)JC

Abstract

BACKGROUND

The aim of this study was to investigate the diagnostic accuracy of symptoms and signs in healthcare workers (HCW) with Sars-CoV-2.

METHODS

This was a case-control study. Cases consisted of symptomatic healthcare workers who had a positive SARS-CoV-2 real-time polymerase chain reaction (RT-PCR) test, while controls were symptomatic healthcare workers with a negative RT-PCR test. For each symptom, ROCs were plotted. Diagnostic accuracy was calculated using the sensitivity, specificity, and positive and negative predictive values. A logistic regression analysis was carried out for calculating the OR (95% CI) for each symptom associated to the SARS-CoV-2 positivity.

RESULTS

We recruited 30 cases and 75 controls. Fever had the best sensitivity while dyspnea, anosmia, and ageusia had the highest specificity. The highest PPVs were found again for dyspnea (75%), anosmia (73.7%), and ageusia (66.7%). Lastly, the highest NPVs were related to anosmia (81.4%) and ageusia (79.3%). Anosmia (OR = 14.75; 95% CI: 4.27-50.87), ageusia (OR = 9.18; 95% CI: 2.80-30.15), and headache (OR = 3.92; 95% CI: 1.45-10.56) are significantly associated to SARS-CoV-2 positivity.

CONCLUSIONS

Anosmia and ageusia should be considered in addition to the well-established fever, cough, and dyspnea. In a resource-limited setting, this method could save time and money.

Authors+Show Affiliations

Department of Public health and Infectious Diseases, Sapienza University of Rome, 00185 Rome, Italy.Department of Public health and Infectious Diseases, Sapienza University of Rome, 00185 Rome, Italy. Department of Infectious Diseases, Teaching Hospital "Policlinico Umberto I", Sapienza University, 00185 Rome, Italy.Department of Molecular Medicine, Teaching Hospital "Policlinico Umberto I", Sapienza University, 00185 Rome, Italy.Department of Public health and Infectious Diseases, Sapienza University of Rome, 00185 Rome, Italy. Department of Infectious Diseases, Teaching Hospital "Policlinico Umberto I", Sapienza University, 00185 Rome, Italy.Department of Public health and Infectious Diseases, Sapienza University of Rome, 00185 Rome, Italy.Department of Public health and Infectious Diseases, Sapienza University of Rome, 00185 Rome, Italy.Department of Public health and Infectious Diseases, Sapienza University of Rome, 00185 Rome, Italy.Department of Public health and Infectious Diseases, Sapienza University of Rome, 00185 Rome, Italy.Department of Molecular Medicine, Teaching Hospital "Policlinico Umberto I", Sapienza University, 00185 Rome, Italy.Division of Anesthesiology and Intensive Care, Teaching Hospital "Policlinico Umberto I", Sapienza University of Rome, 00185 Rome, Italy.Department of Public health and Infectious Diseases, Sapienza University of Rome, 00185 Rome, Italy.Department of Public health and Infectious Diseases, Sapienza University of Rome, 00185 Rome, Italy.Department of Public health and Infectious Diseases, Sapienza University of Rome, 00185 Rome, Italy. Department of Infectious Diseases, Teaching Hospital "Policlinico Umberto I", Sapienza University, 00185 Rome, Italy.Covid-19 Sapienza Collaborative group, Sapienza University of Rome, 00185 Rome, Italy.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

32899778

Citation

La Torre, Giuseppe, et al. "Anosmia and Ageusia as Predictive Signs of COVID-19 in Healthcare Workers in Italy: a Prospective Case-Control Study." Journal of Clinical Medicine, vol. 9, no. 9, 2020.
La Torre G, Massetti AP, Antonelli G, et al. Anosmia and Ageusia as Predictive Signs of COVID-19 in Healthcare Workers in Italy: A Prospective Case-Control Study. J Clin Med. 2020;9(9).
La Torre, G., Massetti, A. P., Antonelli, G., Fimiani, C., Fantini, M., Marte, M., Faticoni, A., Previte, C. M., Turriziani, O., Pugliese, F., Villari, P., Romano, F., Mastroianni, C. M., & Covid-Sapienza Collaborative Group, . (2020). Anosmia and Ageusia as Predictive Signs of COVID-19 in Healthcare Workers in Italy: A Prospective Case-Control Study. Journal of Clinical Medicine, 9(9). https://doi.org/10.3390/jcm9092870
La Torre G, et al. Anosmia and Ageusia as Predictive Signs of COVID-19 in Healthcare Workers in Italy: a Prospective Case-Control Study. J Clin Med. 2020 Sep 4;9(9) PubMed PMID: 32899778.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Anosmia and Ageusia as Predictive Signs of COVID-19 in Healthcare Workers in Italy: A Prospective Case-Control Study. AU - La Torre,Giuseppe, AU - Massetti,Anna Paola, AU - Antonelli,Guido, AU - Fimiani,Caterina, AU - Fantini,Mauro, AU - Marte,Mattia, AU - Faticoni,Augusto, AU - Previte,Carlo Maria, AU - Turriziani,Ombretta, AU - Pugliese,Francesco, AU - Villari,Paolo, AU - Romano,Ferdinando, AU - Mastroianni,Claudio Maria, AU - Covid-Sapienza Collaborative Group,, Y1 - 2020/09/04/ PY - 2020/07/28/received PY - 2020/08/21/revised PY - 2020/08/31/accepted PY - 2020/9/9/entrez PY - 2020/9/10/pubmed PY - 2020/9/10/medline KW - COVID-19 KW - Italy KW - SARS-CoV-2 KW - ageusia KW - anosmia KW - healthcare workers KW - signs KW - symptoms JF - Journal of clinical medicine JO - J Clin Med VL - 9 IS - 9 N2 - BACKGROUND: The aim of this study was to investigate the diagnostic accuracy of symptoms and signs in healthcare workers (HCW) with Sars-CoV-2. METHODS: This was a case-control study. Cases consisted of symptomatic healthcare workers who had a positive SARS-CoV-2 real-time polymerase chain reaction (RT-PCR) test, while controls were symptomatic healthcare workers with a negative RT-PCR test. For each symptom, ROCs were plotted. Diagnostic accuracy was calculated using the sensitivity, specificity, and positive and negative predictive values. A logistic regression analysis was carried out for calculating the OR (95% CI) for each symptom associated to the SARS-CoV-2 positivity. RESULTS: We recruited 30 cases and 75 controls. Fever had the best sensitivity while dyspnea, anosmia, and ageusia had the highest specificity. The highest PPVs were found again for dyspnea (75%), anosmia (73.7%), and ageusia (66.7%). Lastly, the highest NPVs were related to anosmia (81.4%) and ageusia (79.3%). Anosmia (OR = 14.75; 95% CI: 4.27-50.87), ageusia (OR = 9.18; 95% CI: 2.80-30.15), and headache (OR = 3.92; 95% CI: 1.45-10.56) are significantly associated to SARS-CoV-2 positivity. CONCLUSIONS: Anosmia and ageusia should be considered in addition to the well-established fever, cough, and dyspnea. In a resource-limited setting, this method could save time and money. SN - 2077-0383 UR - https://www.unboundmedicine.com/medline/citation/32899778/Anosmia_and_Ageusia_as_Predictive_Signs_of_COVID_19_in_Healthcare_Workers_in_Italy:_A_Prospective_Case_Control_Study_ L2 - https://www.mdpi.com/resolver?pii=jcm9092870 DB - PRIME DP - Unbound Medicine ER -
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