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COVID-19 and Kidney Injury.
R I Med J (2013). 2020 Sep 04; 103(8):24-28.RI

Abstract

BACKGROUND

Acute kidney injury (AKI) has been reported as a complication of COVID-19. However, the epidemiology, management, and associated outcomes have varied greatly between studies. The pathophysiology remains unclear. Summary: The etiology of AKI in the setting of COVID-19 appears multifactorial. Systemic effects of sepsis, inflammation, and vascular injury likely play some role. Furthermore, SARS-CoV-2 binds to the angiotensin-converting enzyme 2 receptor, highly expressed in the kidney, providing a route for direct infection. Older age, baseline comorbidities, and respiratory failure are strong risk factors for the development of AKI. Regardless of etiology, AKI carries a significantly increased risk for in-hospital mortality, especially in those with critical illness. Currently, management of AKI in patients with COVID-19 remains supportive. Key Messages: AKI is common in patients with COVID-19. Future studies are needed to examine the response to anti-viral treatment as well as long-term renal outcomes in patients with AKI.

Authors+Show Affiliations

Division of Kidney Diseases and Hypertension, Department of Medicine, Alpert Medical School of Brown University, Providence, RI.Division of Kidney Diseases and Hypertension, Department of Medicine, Alpert Medical School of Brown University, Providence, RI.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

32900008

Citation

Lynch, Matthew R., and Jie Tang. "COVID-19 and Kidney Injury." Rhode Island Medical Journal (2013), vol. 103, no. 8, 2020, pp. 24-28.
Lynch MR, Tang J. COVID-19 and Kidney Injury. R I Med J (2013). 2020;103(8):24-28.
Lynch, M. R., & Tang, J. (2020). COVID-19 and Kidney Injury. Rhode Island Medical Journal (2013), 103(8), 24-28.
Lynch MR, Tang J. COVID-19 and Kidney Injury. R I Med J (2013). 2020 Sep 4;103(8):24-28. PubMed PMID: 32900008.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - COVID-19 and Kidney Injury. AU - Lynch,Matthew R, AU - Tang,Jie, Y1 - 2020/09/04/ PY - 2020/9/9/entrez PY - 2020/9/10/pubmed PY - 2020/9/17/medline KW - ACE2 KW - COVID-19 KW - acute kidney injury SP - 24 EP - 28 JF - Rhode Island medical journal (2013) JO - R I Med J (2013) VL - 103 IS - 8 N2 - BACKGROUND: Acute kidney injury (AKI) has been reported as a complication of COVID-19. However, the epidemiology, management, and associated outcomes have varied greatly between studies. The pathophysiology remains unclear. Summary: The etiology of AKI in the setting of COVID-19 appears multifactorial. Systemic effects of sepsis, inflammation, and vascular injury likely play some role. Furthermore, SARS-CoV-2 binds to the angiotensin-converting enzyme 2 receptor, highly expressed in the kidney, providing a route for direct infection. Older age, baseline comorbidities, and respiratory failure are strong risk factors for the development of AKI. Regardless of etiology, AKI carries a significantly increased risk for in-hospital mortality, especially in those with critical illness. Currently, management of AKI in patients with COVID-19 remains supportive. Key Messages: AKI is common in patients with COVID-19. Future studies are needed to examine the response to anti-viral treatment as well as long-term renal outcomes in patients with AKI. SN - 2327-2228 UR - https://www.unboundmedicine.com/medline/citation/32900008/COVID_19_and_Kidney_Injury_ L2 - http://rimed.org/rimedicaljournal/2020/10/2020-10-24-covid-kidney-lynch.pdf DB - PRIME DP - Unbound Medicine ER -