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Comparison of clinical characteristics between fecal/perianal swab nucleic acid-positive and -negative patients with COVID-19.
J Infect Dev Ctries. 2020 08 31; 14(8):847-852.JI

Abstract

INTRODUCTION

We analyzed the clinical characteristics of COVID-19 fecal/perianal swab nucleic acid-positive patients in our hospital and evaluated the effect of SARS-CoV-2 on the gastrointestinal tract.

METHODOLOGY

Ninety-seven patients in the Fifth Affiliated Hospital of Sun Yat-sen University from January 17, 2020 to March 2, 2020 with fecal/perianal swab samples were selected as subjects and the results of real-time fluorescence reverse transcriptase-PCR SARS-CoV-2 nucleic acid detection of fecal/perianal swabs were used to divide subjects into positive and negative groups.

RESULTS

Fecal/perianal swabs of 53.61% (52/97) patients were positive including 31 males (59.62%) and 21 females (40.38%). The negative group had more females than males (P = 0.001). The distribution of case classification based on the most severe condition observed after admission was different between groups: five (5.15%) critical type patients were all from the positive group (P = 0.029). There was no statistical difference in clinical manifestations between the groups. In the positive group, the mean nucleic acid-negative conversion time was 14.13 ± 8.61 days, which was significantly later than the negative group (6.98 ± 5.16 days; P < 0.001). In the positive group, 92% (48/52) had nucleic acid-negative conversion with a mean nucleic acid-negative conversion time of 22.58 ± 10.30 days. Among them, 41 (78.85%) cases were delayed compared with pharynx/nasal swab nucleic acid-negative conversion time.

CONCLUSIONS

The positive rate of fecal/perianal swab nucleic acid in male patients was higher than that in female patients. Fecal/perianal swab nucleic acid positive may be an indicator of critical conditions in those with COVID-19.

Authors+Show Affiliations

Department of Infectious Diseases, The Fifth Affiliated Hospital, Sun Yat-sen University, Zhuhai, China. Haizi2308@sina.com.Department of Infectious Diseases, The Fifth Affiliated Hospital, Sun Yat-sen University, Zhuhai, China. luowt7@mail2.sysu.edu.cn.Department of Infectious Diseases, The Fifth Affiliated Hospital, Sun Yat-sen University, Zhuhai, China. 2289580157@qq.com.Department of Infectious Diseases, The Fifth Affiliated Hospital, Sun Yat-sen University, Zhuhai, China. lichunna@mail.sysu.edu.cn.Department of Infectious Diseases, The Fifth Affiliated Hospital, Sun Yat-sen University, Zhuhai, China. hongzhs@mail.sysu.edu.cn.Department of Infectious Diseases, The Fifth Affiliated Hospital, Sun Yat-sen University, Zhuhai, China. xiajinyu@mail.sysu.edu.cn.Department of Infectious Diseases, The Fifth Affiliated Hospital, Sun Yat-sen University, Zhuhai, China. liuxi26@mail.sysu.edu.cn.

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

32903228

Citation

Chen, Gong-Qi, et al. "Comparison of Clinical Characteristics Between Fecal/perianal Swab Nucleic Acid-positive and -negative Patients With COVID-19." Journal of Infection in Developing Countries, vol. 14, no. 8, 2020, pp. 847-852.
Chen GQ, Luo WT, Zhao CH, et al. Comparison of clinical characteristics between fecal/perianal swab nucleic acid-positive and -negative patients with COVID-19. J Infect Dev Ctries. 2020;14(8):847-852.
Chen, G. Q., Luo, W. T., Zhao, C. H., Li, C. N., Hong, Z. S., Xia, J. Y., & Liu, X. (2020). Comparison of clinical characteristics between fecal/perianal swab nucleic acid-positive and -negative patients with COVID-19. Journal of Infection in Developing Countries, 14(8), 847-852. https://doi.org/10.3855/jidc.12885
Chen GQ, et al. Comparison of Clinical Characteristics Between Fecal/perianal Swab Nucleic Acid-positive and -negative Patients With COVID-19. J Infect Dev Ctries. 2020 08 31;14(8):847-852. PubMed PMID: 32903228.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Comparison of clinical characteristics between fecal/perianal swab nucleic acid-positive and -negative patients with COVID-19. AU - Chen,Gong-Qi, AU - Luo,Wen-Tao, AU - Zhao,Chao-Hui, AU - Li,Chun-Na, AU - Hong,Zhong-Si, AU - Xia,Jin-Yu, AU - Liu,Xi, Y1 - 2020/08/31/ PY - 2020/04/24/received PY - 2020/07/20/accepted PY - 2020/9/9/entrez PY - 2020/9/10/pubmed PY - 2020/9/23/medline KW - ACE2 KW - COVID-19 KW - PCR KW - SARS-CoV-2 KW - clinical characteristics KW - fecal swab SP - 847 EP - 852 JF - Journal of infection in developing countries JO - J Infect Dev Ctries VL - 14 IS - 8 N2 - INTRODUCTION: We analyzed the clinical characteristics of COVID-19 fecal/perianal swab nucleic acid-positive patients in our hospital and evaluated the effect of SARS-CoV-2 on the gastrointestinal tract. METHODOLOGY: Ninety-seven patients in the Fifth Affiliated Hospital of Sun Yat-sen University from January 17, 2020 to March 2, 2020 with fecal/perianal swab samples were selected as subjects and the results of real-time fluorescence reverse transcriptase-PCR SARS-CoV-2 nucleic acid detection of fecal/perianal swabs were used to divide subjects into positive and negative groups. RESULTS: Fecal/perianal swabs of 53.61% (52/97) patients were positive including 31 males (59.62%) and 21 females (40.38%). The negative group had more females than males (P = 0.001). The distribution of case classification based on the most severe condition observed after admission was different between groups: five (5.15%) critical type patients were all from the positive group (P = 0.029). There was no statistical difference in clinical manifestations between the groups. In the positive group, the mean nucleic acid-negative conversion time was 14.13 ± 8.61 days, which was significantly later than the negative group (6.98 ± 5.16 days; P < 0.001). In the positive group, 92% (48/52) had nucleic acid-negative conversion with a mean nucleic acid-negative conversion time of 22.58 ± 10.30 days. Among them, 41 (78.85%) cases were delayed compared with pharynx/nasal swab nucleic acid-negative conversion time. CONCLUSIONS: The positive rate of fecal/perianal swab nucleic acid in male patients was higher than that in female patients. Fecal/perianal swab nucleic acid positive may be an indicator of critical conditions in those with COVID-19. SN - 1972-2680 UR - https://www.unboundmedicine.com/medline/citation/32903228/Comparison_of_clinical_characteristics_between_fecal/perianal_swab_nucleic_acid_positive_and__negative_patients_with_COVID_19_ L2 - http://www.jidc.org/index.php/journal/article/view/32903228 DB - PRIME DP - Unbound Medicine ER -