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Autonomic Dysfunction in the Synucleinopathies.
Semin Neurol. 2020 Oct; 40(5):492-501.SN

Abstract

Autonomic dysfunction is a characteristic feature in the synucleinopathies. Differences in cellular deposition and neuronal populations affected by α-synuclein aggregation influence the manifestations and severity of autonomic failure in the different synucleinopathy disorders. The Lewy body disorders (Parkinson's disease, dementia with Lewy bodies, and pure autonomic failure) have predominantly peripheral involvement, whereas multiple system atrophy chiefly manifests as central autonomic failure. Clinical and laboratory features may be useful in distinguishing the different synucleinopathies based on the pattern and severity of autonomic failure. Treatment recommendations are aimed at the underlying pathophysiology and utilize non-pharmacologic and pharmacologic approaches. This review will focus on pathophysiology, clinical manifestations, and management recommendations for autonomic failure including neurogenic orthostatic hypotension, thermoregulatory dysfunction, genitourinary dysfunction, and gastrointestinal dysfunction in the synucleinopathies.

Authors+Show Affiliations

Department of Neurology, Mayo Clinic, Rochester, Minnesota.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

32906169

Citation

Coon, Elizabeth A.. "Autonomic Dysfunction in the Synucleinopathies." Seminars in Neurology, vol. 40, no. 5, 2020, pp. 492-501.
Coon EA. Autonomic Dysfunction in the Synucleinopathies. Semin Neurol. 2020;40(5):492-501.
Coon, E. A. (2020). Autonomic Dysfunction in the Synucleinopathies. Seminars in Neurology, 40(5), 492-501. https://doi.org/10.1055/s-0040-1713844
Coon EA. Autonomic Dysfunction in the Synucleinopathies. Semin Neurol. 2020;40(5):492-501. PubMed PMID: 32906169.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Autonomic Dysfunction in the Synucleinopathies. A1 - Coon,Elizabeth A, Y1 - 2020/09/09/ PY - 2020/9/10/pubmed PY - 2020/9/10/medline PY - 2020/9/9/entrez SP - 492 EP - 501 JF - Seminars in neurology JO - Semin Neurol VL - 40 IS - 5 N2 - Autonomic dysfunction is a characteristic feature in the synucleinopathies. Differences in cellular deposition and neuronal populations affected by α-synuclein aggregation influence the manifestations and severity of autonomic failure in the different synucleinopathy disorders. The Lewy body disorders (Parkinson's disease, dementia with Lewy bodies, and pure autonomic failure) have predominantly peripheral involvement, whereas multiple system atrophy chiefly manifests as central autonomic failure. Clinical and laboratory features may be useful in distinguishing the different synucleinopathies based on the pattern and severity of autonomic failure. Treatment recommendations are aimed at the underlying pathophysiology and utilize non-pharmacologic and pharmacologic approaches. This review will focus on pathophysiology, clinical manifestations, and management recommendations for autonomic failure including neurogenic orthostatic hypotension, thermoregulatory dysfunction, genitourinary dysfunction, and gastrointestinal dysfunction in the synucleinopathies. SN - 1098-9021 UR - https://www.unboundmedicine.com/medline/citation/32906169/Autonomic_Dysfunction_in_the_Synucleinopathies_ L2 - https://www.thieme-connect.com/DOI/DOI?10.1055/s-0040-1713844 DB - PRIME DP - Unbound Medicine ER -