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Glucagon responses to intravenous arginine and oral glucose in insulin-dependent diabetic patients during six months conventional or continuous subcutaneous insulin infusion.
Metabolism. 1988 Jul; 37(7):640-4.M

Abstract

To elucidate the impact of subcutaneous insulin infusion (CSII) treatment on the glucagon response to intravenous (IV) arginine and to oral glucose a 6-month prospective randomized study in insulin-dependent diabetics was carried out. The effects were investigated of CSII (7-patients) and conventional insulin treatment (UCT) (9 patients) on the changes in glucagon, growth hormone, glucose, lactate, glycerol, 3-hydroxybutyrate, and alanine to IV arginine and to oral glucose in insulin-dependent diabetics who were made euglycemic and isoinsulinemic using the artificial pancreas (Biostator, Miles, Elkhart, IN). HbA1c was significantly lower in the group treated by CSII. Despite the improved glycemic control no significant change in the responses of A-cell secretion to arginine or glucose challenges was found. In addition, there were no significant differences in hormone or metabolite values between the two groups at entry to the study or after 6 months of either therapy. Thus, normalization of the A-cell sensitivity to glucose in insulin-dependent diabetic subjects requires further amelioration of the intermediary metabolism than can be achieved with insulin pump treatment.

Authors+Show Affiliations

Hermansen K
Second University Clinic of Internal Medicine, Aarhus Kommunehospital, Denmark.
Schmitz O
No affiliation info available
Boye N
No affiliation info available
Christensen CK
No affiliation info available
Christiansen JS
No affiliation info available
Alberti KG
No affiliation info available
Orskov H
No affiliation info available
Mogensen CE
No affiliation info available

MeSH

Administration, OralAdultArginineBlood GlucoseDiabetes Mellitus, Type 1FemaleGlucagonGlucoseGrowth HormoneHumansInjections, IntravenousInsulinInsulin Infusion SystemsMaleTime Factors

Pub Type(s)

Clinical Trial
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

3290622

Citation

Hermansen, K, et al. "Glucagon Responses to Intravenous Arginine and Oral Glucose in Insulin-dependent Diabetic Patients During Six Months Conventional or Continuous Subcutaneous Insulin Infusion." Metabolism: Clinical and Experimental, vol. 37, no. 7, 1988, pp. 640-4.
Hermansen K, Schmitz O, Boye N, et al. Glucagon responses to intravenous arginine and oral glucose in insulin-dependent diabetic patients during six months conventional or continuous subcutaneous insulin infusion. Metabolism. 1988;37(7):640-4.
Hermansen, K., Schmitz, O., Boye, N., Christensen, C. K., Christiansen, J. S., Alberti, K. G., Orskov, H., & Mogensen, C. E. (1988). Glucagon responses to intravenous arginine and oral glucose in insulin-dependent diabetic patients during six months conventional or continuous subcutaneous insulin infusion. Metabolism: Clinical and Experimental, 37(7), 640-4.
Hermansen K, et al. Glucagon Responses to Intravenous Arginine and Oral Glucose in Insulin-dependent Diabetic Patients During Six Months Conventional or Continuous Subcutaneous Insulin Infusion. Metabolism. 1988;37(7):640-4. PubMed PMID: 3290622.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Glucagon responses to intravenous arginine and oral glucose in insulin-dependent diabetic patients during six months conventional or continuous subcutaneous insulin infusion. AU - Hermansen,K, AU - Schmitz,O, AU - Boye,N, AU - Christensen,C K, AU - Christiansen,J S, AU - Alberti,K G, AU - Orskov,H, AU - Mogensen,C E, PY - 1988/7/1/pubmed PY - 1988/7/1/medline PY - 1988/7/1/entrez SP - 640 EP - 4 JF - Metabolism: clinical and experimental JO - Metabolism VL - 37 IS - 7 N2 - To elucidate the impact of subcutaneous insulin infusion (CSII) treatment on the glucagon response to intravenous (IV) arginine and to oral glucose a 6-month prospective randomized study in insulin-dependent diabetics was carried out. The effects were investigated of CSII (7-patients) and conventional insulin treatment (UCT) (9 patients) on the changes in glucagon, growth hormone, glucose, lactate, glycerol, 3-hydroxybutyrate, and alanine to IV arginine and to oral glucose in insulin-dependent diabetics who were made euglycemic and isoinsulinemic using the artificial pancreas (Biostator, Miles, Elkhart, IN). HbA1c was significantly lower in the group treated by CSII. Despite the improved glycemic control no significant change in the responses of A-cell secretion to arginine or glucose challenges was found. In addition, there were no significant differences in hormone or metabolite values between the two groups at entry to the study or after 6 months of either therapy. Thus, normalization of the A-cell sensitivity to glucose in insulin-dependent diabetic subjects requires further amelioration of the intermediary metabolism than can be achieved with insulin pump treatment. SN - 0026-0495 UR - https://www.unboundmedicine.com/medline/citation/3290622/Glucagon_responses_to_intravenous_arginine_and_oral_glucose_in_insulin_dependent_diabetic_patients_during_six_months_conventional_or_continuous_subcutaneous_insulin_infusion_ DB - PRIME DP - Unbound Medicine ER -