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Effect of chronic obstructive pulmonary disease and smoking on the outcome of COVID-19.
Int J Tuberc Lung Dis. 2020 08 01; 24(8):838-843.IJ

Abstract

OBJECTIVE:

To investigate the association between chronic obstructive pulmonary disease (COPD) and smoking with outcome in patients with COVID-19.

METHODS:

A systematic literature search was performed using PubMed, EuropePMC, SCOPUS and the Cochrane Central Database. A composite of poor outcome, mortality, severe COVID-19, the need for treatment in an intensive care unit (ICU) and disease progression were the outcomes of interest.

RESULTS:

Data on 4603 patients were pooled from 21 studies. COPD was associated with an increased risk for composite poor outcome (OR 5.01, 95%CI 3.06-8.22; P < 0.001; I² 0%), mortality (OR 4.36, 95%CI 1.45-13.10; P = 0.009; I² 0%), severe COVID-19 (OR 4.62, 95%CI 2.49-8.56; P < 0.001; I² 0%), ICU care (OR 8.33, 95%CI 1.27-54.56; P = 0.03; I² 0%), and disease progression (OR 8.42, 95%CI 1.60-44.27; P = 0.01; I² 0%). Smoking was found to increase the risk of composite poor outcome (OR 1.52, 95%CI 1.16-2.00; P = 0.005; I² 12%), and subgroup analysis showed that smoking was significant for increased risk of severe COVID-19 (OR 1.65, 95%CI 1.17-2.34; P = 0.004; I² 11%). Current smokers were at higher risk of composite poor outcomes (OR 1.58, 95%CI 1.10-2.27; P = 0.01; I² 0%) than former/non-smokers.

CONCLUSION:

Our systematic review and meta-analysis revealed that COPD and smoking were associated with poor outcomes in patients with COVID-19.

Authors+Show Affiliations

Faculty of Medicine, Universitas Pelita Harapan, Tangerang, Indonesia.Division of Respirology and Critical Illness, Department of Internal Medicine.Faculty of Medicine, Universitas Pelita Harapan, Tangerang, Indonesia, Department of Internal Medicine, Faculty of Medicine.Faculty of Medicine, Universitas Pelita Harapan, Tangerang, Indonesia.Division of Respirology and Critical Illness, Department of Internal Medicine.Division of Endocrinology and Metabolism, Department of Internal Medicine, Faculty of Medicine, Universitas Padjadjaran, Hasan Sadikin General Hospital, Bandung, Indonesia.Faculty of Medicine, Universitas Pelita Harapan, Tangerang, Indonesia, Department of Cardiology and Vascular Medicine, Siloam Hospitals Lippo Village, Tangerang, Indonesia.

Pub Type(s)

Journal Article
Comment

Language

eng

PubMed ID

32912389

Citation

Pranata, R, et al. "Effect of Chronic Obstructive Pulmonary Disease and Smoking On the Outcome of COVID-19." The International Journal of Tuberculosis and Lung Disease : the Official Journal of the International Union Against Tuberculosis and Lung Disease, vol. 24, no. 8, 2020, pp. 838-843.
Pranata R, Soeroto AY, Huang I, et al. Effect of chronic obstructive pulmonary disease and smoking on the outcome of COVID-19. Int J Tuberc Lung Dis. 2020;24(8):838-843.
Pranata, R., Soeroto, A. Y., Huang, I., Lim, M. A., Santoso, P., Permana, H., & Lukito, A. A. (2020). Effect of chronic obstructive pulmonary disease and smoking on the outcome of COVID-19. The International Journal of Tuberculosis and Lung Disease : the Official Journal of the International Union Against Tuberculosis and Lung Disease, 24(8), 838-843. https://doi.org/10.5588/ijtld.20.0278
Pranata R, et al. Effect of Chronic Obstructive Pulmonary Disease and Smoking On the Outcome of COVID-19. Int J Tuberc Lung Dis. 2020 08 1;24(8):838-843. PubMed PMID: 32912389.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of chronic obstructive pulmonary disease and smoking on the outcome of COVID-19. AU - Pranata,R, AU - Soeroto,A Y, AU - Huang,I, AU - Lim,M A, AU - Santoso,P, AU - Permana,H, AU - Lukito,A A, PY - 2020/9/11/entrez PY - 2020/9/12/pubmed PY - 2020/9/18/medline SP - 838 EP - 843 JF - The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease JO - Int J Tuberc Lung Dis VL - 24 IS - 8 N2 - OBJECTIVE: To investigate the association between chronic obstructive pulmonary disease (COPD) and smoking with outcome in patients with COVID-19.METHODS: A systematic literature search was performed using PubMed, EuropePMC, SCOPUS and the Cochrane Central Database. A composite of poor outcome, mortality, severe COVID-19, the need for treatment in an intensive care unit (ICU) and disease progression were the outcomes of interest.RESULTS: Data on 4603 patients were pooled from 21 studies. COPD was associated with an increased risk for composite poor outcome (OR 5.01, 95%CI 3.06-8.22; P < 0.001; I² 0%), mortality (OR 4.36, 95%CI 1.45-13.10; P = 0.009; I² 0%), severe COVID-19 (OR 4.62, 95%CI 2.49-8.56; P < 0.001; I² 0%), ICU care (OR 8.33, 95%CI 1.27-54.56; P = 0.03; I² 0%), and disease progression (OR 8.42, 95%CI 1.60-44.27; P = 0.01; I² 0%). Smoking was found to increase the risk of composite poor outcome (OR 1.52, 95%CI 1.16-2.00; P = 0.005; I² 12%), and subgroup analysis showed that smoking was significant for increased risk of severe COVID-19 (OR 1.65, 95%CI 1.17-2.34; P = 0.004; I² 11%). Current smokers were at higher risk of composite poor outcomes (OR 1.58, 95%CI 1.10-2.27; P = 0.01; I² 0%) than former/non-smokers.CONCLUSION: Our systematic review and meta-analysis revealed that COPD and smoking were associated with poor outcomes in patients with COVID-19. SN - 1815-7920 UR - https://www.unboundmedicine.com/medline/citation/32912389/Effect_of_chronic_obstructive_pulmonary_disease_and_smoking_on_the_outcome_of_COVID_19_ L2 - https://www.ingentaconnect.com/openurl?genre=article&amp;issn=1815-7920&amp;volume=24&amp;issue=8&amp;spage=838&amp;aulast=Pranata DB - PRIME DP - Unbound Medicine ER -