Tags

Type your tag names separated by a space and hit enter

Prevalence and Associated Risk Factors of Mortality Among COVID-19 Patients: A Meta-Analysis.
J Community Health. 2020 12; 45(6):1270-1282.JC

Abstract

OBJECTIVES

The main aim of this study was to find the prevalence of mortality among hospitalized COVID-19 infected patients and associated risk factors for death.

METHODS

Three electronic databases including PubMed, Science Direct and Google Scholar were searched to identify relevant cohort studies of COVID-19 disease from January 1, 2020, to August 11, 2020. A random-effects model was used to calculate pooled prevalence rate (PR), risk ratio (RR) and 95% confidence interval (CI) for both effect measures. Cochrane chi-square test statistic Q, [Formula: see text], and [Formula: see text] tests were used to measure the presence of heterogeneity. Publication bias and sensitivity of the included studies were also tested.

RESULTS

In this meta-analysis, a total of 58 studies with 122,191 patients were analyzed. The pooled prevalence rate of mortality among the hospitalized COVID-19 patients was 18.88%, 95% CI (16.46-21.30), p < 0.001. Highest mortality was found in Europe [PR 26.85%, 95% CI (19.41-34.29), p < 0.001] followed by North America [PR 21.47%, 95% CI (16.27-26.68), p < 0.001] and Asia [PR 14.83%, 95% CI (12.46- 17.21), p < 0.001]. An significant association were found between mortality among COVID-19 infected patients and older age (> 65 years vs. < 65 years) [RR 3.59, 95% CI (1.87-6.90), p < 0.001], gender (male vs. female) [RR 1.63, 95% CI (1.43-1.87), p < 0.001], ICU admitted patients [RR 3.72, 95% CI (2.70-5.13), p < 0.001], obesity [RR 2.18, 95% CI (1.10-4.34), p < 0.05], hypertension [RR 2.08,95% CI (1.79-2.43) p < 0.001], diabetes [RR 1.87, 95% CI (1.23-2.84), p < 0.001], cardiovascular disease [RR 2.51, 95% CI (1.20-5.26), p < 0.05], and cancer [RR 2.31, 95% CI (1.80-2.97), p < 0.001]. In addition, significant association for high risk of mortality were also found for cerebrovascular disease, COPD, coronary heart disease, chronic renal disease, chronic liver disease, chronic lung disease and chronic kidney disease.

CONCLUSION

This meta-analysis revealed that the mortality rate among COVID-19 patients was highest in the European region and older age, gender, ICU patients, patients with comorbidity had a high risk for case fatality. Those findings would help the health care providers to reduce the mortality rate and combat this pandemic to save lives using limited resources.

Authors+Show Affiliations

M.Sc. Department of Statistics, University of Dhaka, Dhaka, 1000, Bangladesh. farha90932@gmail.com.M.Sc. Department of Statistics, University of Dhaka, Dhaka, 1000, Bangladesh.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

32918645

Citation

Noor, Farha Musharrat, and Md Momin Islam. "Prevalence and Associated Risk Factors of Mortality Among COVID-19 Patients: a Meta-Analysis." Journal of Community Health, vol. 45, no. 6, 2020, pp. 1270-1282.
Noor FM, Islam MM. Prevalence and Associated Risk Factors of Mortality Among COVID-19 Patients: A Meta-Analysis. J Community Health. 2020;45(6):1270-1282.
Noor, F. M., & Islam, M. M. (2020). Prevalence and Associated Risk Factors of Mortality Among COVID-19 Patients: A Meta-Analysis. Journal of Community Health, 45(6), 1270-1282. https://doi.org/10.1007/s10900-020-00920-x
Noor FM, Islam MM. Prevalence and Associated Risk Factors of Mortality Among COVID-19 Patients: a Meta-Analysis. J Community Health. 2020;45(6):1270-1282. PubMed PMID: 32918645.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Prevalence and Associated Risk Factors of Mortality Among COVID-19 Patients: A Meta-Analysis. AU - Noor,Farha Musharrat, AU - Islam,Md Momin, PY - 2020/9/13/pubmed PY - 2020/11/13/medline PY - 2020/9/12/entrez KW - COVID-19 KW - Comorbidity KW - Meta-analysis KW - Mortality KW - Risk factors SP - 1270 EP - 1282 JF - Journal of community health JO - J Community Health VL - 45 IS - 6 N2 - OBJECTIVES: The main aim of this study was to find the prevalence of mortality among hospitalized COVID-19 infected patients and associated risk factors for death. METHODS: Three electronic databases including PubMed, Science Direct and Google Scholar were searched to identify relevant cohort studies of COVID-19 disease from January 1, 2020, to August 11, 2020. A random-effects model was used to calculate pooled prevalence rate (PR), risk ratio (RR) and 95% confidence interval (CI) for both effect measures. Cochrane chi-square test statistic Q, [Formula: see text], and [Formula: see text] tests were used to measure the presence of heterogeneity. Publication bias and sensitivity of the included studies were also tested. RESULTS: In this meta-analysis, a total of 58 studies with 122,191 patients were analyzed. The pooled prevalence rate of mortality among the hospitalized COVID-19 patients was 18.88%, 95% CI (16.46-21.30), p < 0.001. Highest mortality was found in Europe [PR 26.85%, 95% CI (19.41-34.29), p < 0.001] followed by North America [PR 21.47%, 95% CI (16.27-26.68), p < 0.001] and Asia [PR 14.83%, 95% CI (12.46- 17.21), p < 0.001]. An significant association were found between mortality among COVID-19 infected patients and older age (> 65 years vs. < 65 years) [RR 3.59, 95% CI (1.87-6.90), p < 0.001], gender (male vs. female) [RR 1.63, 95% CI (1.43-1.87), p < 0.001], ICU admitted patients [RR 3.72, 95% CI (2.70-5.13), p < 0.001], obesity [RR 2.18, 95% CI (1.10-4.34), p < 0.05], hypertension [RR 2.08,95% CI (1.79-2.43) p < 0.001], diabetes [RR 1.87, 95% CI (1.23-2.84), p < 0.001], cardiovascular disease [RR 2.51, 95% CI (1.20-5.26), p < 0.05], and cancer [RR 2.31, 95% CI (1.80-2.97), p < 0.001]. In addition, significant association for high risk of mortality were also found for cerebrovascular disease, COPD, coronary heart disease, chronic renal disease, chronic liver disease, chronic lung disease and chronic kidney disease. CONCLUSION: This meta-analysis revealed that the mortality rate among COVID-19 patients was highest in the European region and older age, gender, ICU patients, patients with comorbidity had a high risk for case fatality. Those findings would help the health care providers to reduce the mortality rate and combat this pandemic to save lives using limited resources. SN - 1573-3610 UR - https://www.unboundmedicine.com/medline/citation/32918645/Prevalence_and_Associated_Risk_Factors_of_Mortality_Among_COVID_19_Patients:_A_Meta_Analysis_ L2 - https://dx.doi.org/10.1007/s10900-020-00920-x DB - PRIME DP - Unbound Medicine ER -