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The therapeutic potential of convalescent plasma therapy on treating critically-ill COVID-19 patients residing in respiratory care units in hospitals in Baghdad, Iraq.
Infez Med. 2020 Sep 01; 28(3):357-366.IM

Abstract

The current COVID-19 pandemic needs unconventional therapies to tackle the resulted high morbidity and mortality. Convalescent plasma is one of the therapeutic approaches that might be of benefit. Forty nine early-stage critically-ill COVID-19 patients residing in Respiratory Care Units (RCU) of three hospitals in Baghdad, Iraq, were included: 21 received convalescent plasma while 28, namely control group, did not receive it. Recovery or death, length of stay in hospital, and improvement in the clinical course of the disease were monitored clinically along with laboratory monitoring through SARS-CoV-2 RNA detection via PCR, and SARS-CoV-2 IgG and IgM serological monitoring. Patients who received convalescent plasma showed reduced duration of infection in about 4 days and showed less death rate [1/21 versus 8/28 in control group]. In addition, all the patients who were given convalescent plasma showed high levels of SARS-CoV-2 IgG and IgM three days after plasma transfusion. Plasma from donors with high levels of SARS-CoV-2 IgG and donors with positive SRAS-CoV-2 IgM showed better therapeutic results than other donors. Convalescent plasma therapy is an effective therapy if donors with high level of SARS-Cov2 antibodies are selected and if recipients are at their early stage of critical illness, being no more than three days in RCUs.

Authors+Show Affiliations

Alkharkh General Directorate of Health, Alkadymia, Baghdad, Iraq.Alkharkh General Directorate of Health, Alkadymia, Baghdad, Iraq.Alkarkh Hospital, Alatefiya, Baghdad, Iraq.Alforat Hospital, Airport road, Baghdad, Iraq.Alkharkh General Directorate of Health, Alkadymia, Baghdad, Iraq.National Center of Blood Donation, Bab Maadhim, Baghdad, Iraq.College of Medicine, Alnahrain University, Alkadymia, Baghdad, Iraq.

Pub Type(s)

Journal Article
Multicenter Study

Language

eng

PubMed ID

32920571

Citation

Rasheed, Anwar M., et al. "The Therapeutic Potential of Convalescent Plasma Therapy On Treating Critically-ill COVID-19 Patients Residing in Respiratory Care Units in Hospitals in Baghdad, Iraq." Le Infezioni in Medicina, vol. 28, no. 3, 2020, pp. 357-366.
Rasheed AM, Fatak DF, Hashim HA, et al. The therapeutic potential of convalescent plasma therapy on treating critically-ill COVID-19 patients residing in respiratory care units in hospitals in Baghdad, Iraq. Infez Med. 2020;28(3):357-366.
Rasheed, A. M., Fatak, D. F., Hashim, H. A., Maulood, M. F., Kabah, K. K., Almusawi, Y. A., & Abdulamir, A. S. (2020). The therapeutic potential of convalescent plasma therapy on treating critically-ill COVID-19 patients residing in respiratory care units in hospitals in Baghdad, Iraq. Le Infezioni in Medicina, 28(3), 357-366.
Rasheed AM, et al. The Therapeutic Potential of Convalescent Plasma Therapy On Treating Critically-ill COVID-19 Patients Residing in Respiratory Care Units in Hospitals in Baghdad, Iraq. Infez Med. 2020 Sep 1;28(3):357-366. PubMed PMID: 32920571.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The therapeutic potential of convalescent plasma therapy on treating critically-ill COVID-19 patients residing in respiratory care units in hospitals in Baghdad, Iraq. AU - Rasheed,Anwar M, AU - Fatak,Dhurgham F, AU - Hashim,Hashim A, AU - Maulood,Mohammed F, AU - Kabah,Khulood K, AU - Almusawi,Yaqoob A, AU - Abdulamir,Ahmed S, PY - 2020/9/13/entrez PY - 2020/9/14/pubmed PY - 2020/9/25/medline SP - 357 EP - 366 JF - Le infezioni in medicina JO - Infez Med VL - 28 IS - 3 N2 - The current COVID-19 pandemic needs unconventional therapies to tackle the resulted high morbidity and mortality. Convalescent plasma is one of the therapeutic approaches that might be of benefit. Forty nine early-stage critically-ill COVID-19 patients residing in Respiratory Care Units (RCU) of three hospitals in Baghdad, Iraq, were included: 21 received convalescent plasma while 28, namely control group, did not receive it. Recovery or death, length of stay in hospital, and improvement in the clinical course of the disease were monitored clinically along with laboratory monitoring through SARS-CoV-2 RNA detection via PCR, and SARS-CoV-2 IgG and IgM serological monitoring. Patients who received convalescent plasma showed reduced duration of infection in about 4 days and showed less death rate [1/21 versus 8/28 in control group]. In addition, all the patients who were given convalescent plasma showed high levels of SARS-CoV-2 IgG and IgM three days after plasma transfusion. Plasma from donors with high levels of SARS-CoV-2 IgG and donors with positive SRAS-CoV-2 IgM showed better therapeutic results than other donors. Convalescent plasma therapy is an effective therapy if donors with high level of SARS-Cov2 antibodies are selected and if recipients are at their early stage of critical illness, being no more than three days in RCUs. SN - 1124-9390 UR - https://www.unboundmedicine.com/medline/citation/32920571/The_therapeutic_potential_of_convalescent_plasma_therapy_on_treating_critically_ill_COVID_19_patients_residing_in_respiratory_care_units_in_hospitals_in_Baghdad_Iraq_ L2 - https://www.infezmed.it/index.php/article?Anno=2020&numero=3&ArticoloDaVisualizzare=Vol_28_3_2020_357 DB - PRIME DP - Unbound Medicine ER -