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Intussusceptive angiogenesis in Covid-19: hypothesis on the significance and focus on the possible role of FGF2.
Mol Biol Rep. 2020 Oct; 47(10):8301-8304.MB

Abstract

The interest on the role of angiogenesis in the pathogenesis and progression of human interstitial lung diseases is growing, with conventional sprouting (SA) and non-sprouting intussusceptive angiogenesis (IA) being differently represented in specific pulmonary injury patterns. The role of viruses as key regulators of angiogenesis is known for several years. A significantly enhanced amount of new vessel growth, through a mechanism of IA, has been reported in lungs of patients who died from Covid-19; among the angiogenesis-related genes, fibroblast growth factor 2 (FGF2) was found to be upregulated. These findings are intriguing. FGF2 plays a role in some viral infections: the upregulation is involved in the MERS-CoV-induced strong apoptotic response crucial for its highly lytic replication cycle in lung cells, whereas FGF2 is protective against the acute lung injury induced by H1N1 influenza virus, improving the lung wet-to-dry weight ratio. FGF2 plays a role also in regulating IA, acting on pericytes (crucial for the formation of intraluminal pillars), and endothelium, and FGF2-induced angiogenesis may be promoted by inflammation and hypoxia. IA is a faster and probably more efficient process than SA, able to modulate vascular remodeling through pruning of redundant or inefficient blood vessels. We can speculate that IA might have the function of restoring a functional vascular plexus consequently to extensive endothelialitis and alveolar capillary micro-thrombosis observed in Covid-19. Anti-Vascular endothelial growth factor (anti-VEGF) strategies are currently investigated for treatment of severe and critically ill Covid-19 patients, but also FGF2, and its expression and/or signaling, might represent a promising target.

Authors+Show Affiliations

Internal Medicine Unit, Santa Maria Annunziata Hospital, Florence, Italy. simonemeini2@gmail.com.Microbiology and Virology Unit, Careggi Hospital, University of Florence, ‎Florence, Italy.Infectious Diseases Clinic, Santa Maria Misericordia Hospital, University of Udine, Udine, Italy.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

32920756

Citation

Meini, Simone, et al. "Intussusceptive Angiogenesis in Covid-19: Hypothesis On the Significance and Focus On the Possible Role of FGF2." Molecular Biology Reports, vol. 47, no. 10, 2020, pp. 8301-8304.
Meini S, Giani T, Tascini C. Intussusceptive angiogenesis in Covid-19: hypothesis on the significance and focus on the possible role of FGF2. Mol Biol Rep. 2020;47(10):8301-8304.
Meini, S., Giani, T., & Tascini, C. (2020). Intussusceptive angiogenesis in Covid-19: hypothesis on the significance and focus on the possible role of FGF2. Molecular Biology Reports, 47(10), 8301-8304. https://doi.org/10.1007/s11033-020-05831-7
Meini S, Giani T, Tascini C. Intussusceptive Angiogenesis in Covid-19: Hypothesis On the Significance and Focus On the Possible Role of FGF2. Mol Biol Rep. 2020;47(10):8301-8304. PubMed PMID: 32920756.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Intussusceptive angiogenesis in Covid-19: hypothesis on the significance and focus on the possible role of FGF2. AU - Meini,Simone, AU - Giani,Tommaso, AU - Tascini,Carlo, Y1 - 2020/09/12/ PY - 2020/07/19/received PY - 2020/09/07/accepted PY - 2020/09/01/revised PY - 2020/9/14/pubmed PY - 2020/11/18/medline PY - 2020/9/13/entrez KW - Angiogenesis KW - Covid-19 KW - FGF2 KW - Intussusceptive KW - VEGF KW - Virus SP - 8301 EP - 8304 JF - Molecular biology reports JO - Mol Biol Rep VL - 47 IS - 10 N2 - The interest on the role of angiogenesis in the pathogenesis and progression of human interstitial lung diseases is growing, with conventional sprouting (SA) and non-sprouting intussusceptive angiogenesis (IA) being differently represented in specific pulmonary injury patterns. The role of viruses as key regulators of angiogenesis is known for several years. A significantly enhanced amount of new vessel growth, through a mechanism of IA, has been reported in lungs of patients who died from Covid-19; among the angiogenesis-related genes, fibroblast growth factor 2 (FGF2) was found to be upregulated. These findings are intriguing. FGF2 plays a role in some viral infections: the upregulation is involved in the MERS-CoV-induced strong apoptotic response crucial for its highly lytic replication cycle in lung cells, whereas FGF2 is protective against the acute lung injury induced by H1N1 influenza virus, improving the lung wet-to-dry weight ratio. FGF2 plays a role also in regulating IA, acting on pericytes (crucial for the formation of intraluminal pillars), and endothelium, and FGF2-induced angiogenesis may be promoted by inflammation and hypoxia. IA is a faster and probably more efficient process than SA, able to modulate vascular remodeling through pruning of redundant or inefficient blood vessels. We can speculate that IA might have the function of restoring a functional vascular plexus consequently to extensive endothelialitis and alveolar capillary micro-thrombosis observed in Covid-19. Anti-Vascular endothelial growth factor (anti-VEGF) strategies are currently investigated for treatment of severe and critically ill Covid-19 patients, but also FGF2, and its expression and/or signaling, might represent a promising target. SN - 1573-4978 UR - https://www.unboundmedicine.com/medline/citation/32920756/Intussusceptive_angiogenesis_in_Covid_19:_hypothesis_on_the_significance_and_focus_on_the_possible_role_of_FGF2_ L2 - https://doi.org/10.1007/s11033-020-05831-7 DB - PRIME DP - Unbound Medicine ER -