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Photoreceptor responses to light in the pathogenesis of diabetic retinopathy.
Vis Neurosci. 2020 09 14; 37:E007.VN

Abstract

Vision loss, among the most feared complications of diabetes, is primarily caused by diabetic retinopathy, a disease that manifests in well-recognized, characteristic microvascular lesions. The reasons for retinal susceptibility to damage in diabetes are unclear, especially considering that microvascular networks are found in all tissues. However, the unique metabolic demands of retinal neurons could account for their vulnerability in diabetes. Photoreceptors are the first neurons in the visual circuit and are also the most energy-demanding cells of the retina. Here, we review experimental and clinical evidence linking photoreceptors to the development of diabetic retinopathy. We then describe the influence of retinal illumination on photoreceptor metabolism, effects of light modulation on the severity of diabetic retinopathy, and recent clinical trials testing the treatment of diabetic retinopathy with interventions that impact photoreceptor metabolism. Finally, we introduce several possible mechanisms that could link photoreceptor responses to light and the development of retinal vascular disease in diabetes. Collectively, these concepts form the basis for a growing body of investigative efforts aimed at developing novel pharmacologic and nonpharmacologic tools that target photoreceptor physiology to treat a very common cause of blindness across the world.

Authors+Show Affiliations

Department of Ophthalmology and Visual Sciences, Washington University School of Medicine, St. Louis, Missouri. MD-PhD Program, Washington University School of Medicine, St. Louis, Missouri, 63110, USA.Department of Ophthalmology and Visual Sciences, Washington University School of Medicine, St. Louis, Missouri.

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

32921331

Citation

Majidi, Shahriyar P., and Rithwick Rajagopal. "Photoreceptor Responses to Light in the Pathogenesis of Diabetic Retinopathy." Visual Neuroscience, vol. 37, 2020, pp. E007.
Majidi SP, Rajagopal R. Photoreceptor responses to light in the pathogenesis of diabetic retinopathy. Vis Neurosci. 2020;37:E007.
Majidi, S. P., & Rajagopal, R. (2020). Photoreceptor responses to light in the pathogenesis of diabetic retinopathy. Visual Neuroscience, 37, E007. https://doi.org/10.1017/S0952523820000061
Majidi SP, Rajagopal R. Photoreceptor Responses to Light in the Pathogenesis of Diabetic Retinopathy. Vis Neurosci. 2020 09 14;37:E007. PubMed PMID: 32921331.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Photoreceptor responses to light in the pathogenesis of diabetic retinopathy. AU - Majidi,Shahriyar P, AU - Rajagopal,Rithwick, Y1 - 2020/09/14/ PY - 2020/9/14/entrez PY - 2020/9/15/pubmed PY - 2021/10/29/medline KW - Diabetic retinopathy KW - light deprivation KW - metabolism KW - photoreceptor KW - phototransduction KW - visual cycle SP - E007 EP - E007 JF - Visual neuroscience JO - Vis Neurosci VL - 37 N2 - Vision loss, among the most feared complications of diabetes, is primarily caused by diabetic retinopathy, a disease that manifests in well-recognized, characteristic microvascular lesions. The reasons for retinal susceptibility to damage in diabetes are unclear, especially considering that microvascular networks are found in all tissues. However, the unique metabolic demands of retinal neurons could account for their vulnerability in diabetes. Photoreceptors are the first neurons in the visual circuit and are also the most energy-demanding cells of the retina. Here, we review experimental and clinical evidence linking photoreceptors to the development of diabetic retinopathy. We then describe the influence of retinal illumination on photoreceptor metabolism, effects of light modulation on the severity of diabetic retinopathy, and recent clinical trials testing the treatment of diabetic retinopathy with interventions that impact photoreceptor metabolism. Finally, we introduce several possible mechanisms that could link photoreceptor responses to light and the development of retinal vascular disease in diabetes. Collectively, these concepts form the basis for a growing body of investigative efforts aimed at developing novel pharmacologic and nonpharmacologic tools that target photoreceptor physiology to treat a very common cause of blindness across the world. SN - 1469-8714 UR - https://www.unboundmedicine.com/medline/citation/32921331/Photoreceptor_responses_to_light_in_the_pathogenesis_of_diabetic_retinopathy_ L2 - https://www.cambridge.org/core/product/identifier/S0952523820000061/type/journal_article DB - PRIME DP - Unbound Medicine ER -