Tags

Type your tag names separated by a space and hit enter

An Outbreak of Kawasaki-like Disease in children during SARS-CoV- 2 Epidemic: No Surprise?
Acta Biomed. 2020 09 07; 91(3):e2020015.AB

Abstract

BACKGROUND AND AIM

Kawasaki disease is an acute systemic febrile illness of unknown aetiology, which usually affects children under 5 years of age. It is well known that Kawasaki disease is one of the most common causes of acquired heart diseases in children in the developed countries. Many studies, have suggested that heterogeneous infectious agents, such as common viruses, may trigger Kawasaki disease in young children with genetic background.  Nowadays we are facing a pandemic caused by a Novel Coronavirus named SARS-CoV-2. Consequently, it could be possible that once exposed to this new coronavirus, some children, genetically predisposed, may mount an exaggerated inflammatory response which clinically manifests as Kawasaki Disease.

METHODS

from January to May 2020 a systematic search was performed on Pubmed for the following search terms: "COVID-19", "children", "SARS-CoV-2", "complications", "Kawasaki disease", "cytokine storm".

RESULTS

Usually, infants and children present milder symptoms of SARS-CoV-2 disease with a better outcome than adults. At variance, some children may be genetically disposed to a more robust inflammatory response to SARS-CoV-2, similar to Kawasaki disease. In fact, Kawasaki disease is the result of an abnormal immune response, in susceptible children, to an external trigger such as an infection. Thus, according to the pathogenesis of Kawasaki disease, paediatricians may expect an increase in cases of Kawasaki disease during the COVID-19 pandemic.

Authors+Show Affiliations

Array. federica-cavallo@libero.it.University of Chieti. chiarelli@unich.it.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

32921711

Citation

Cavallo, Federica, and Francesco Chiarelli. "An Outbreak of Kawasaki-like Disease in Children During SARS-CoV- 2 Epidemic: No Surprise?" Acta Bio-medica : Atenei Parmensis, vol. 91, no. 3, 2020, pp. e2020015.
Cavallo F, Chiarelli F. An Outbreak of Kawasaki-like Disease in children during SARS-CoV- 2 Epidemic: No Surprise? Acta Biomed. 2020;91(3):e2020015.
Cavallo, F., & Chiarelli, F. (2020). An Outbreak of Kawasaki-like Disease in children during SARS-CoV- 2 Epidemic: No Surprise? Acta Bio-medica : Atenei Parmensis, 91(3), e2020015. https://doi.org/10.23750/abm.v91i3.10305
Cavallo F, Chiarelli F. An Outbreak of Kawasaki-like Disease in Children During SARS-CoV- 2 Epidemic: No Surprise. Acta Biomed. 2020 09 7;91(3):e2020015. PubMed PMID: 32921711.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - An Outbreak of Kawasaki-like Disease in children during SARS-CoV- 2 Epidemic: No Surprise? AU - Cavallo,Federica, AU - Chiarelli,Francesco, Y1 - 2020/09/07/ PY - 2020/07/24/received PY - 2020/07/25/accepted PY - 2020/9/14/entrez PY - 2020/9/15/pubmed PY - 2020/9/23/medline SP - e2020015 EP - e2020015 JF - Acta bio-medica : Atenei Parmensis JO - Acta Biomed VL - 91 IS - 3 N2 - BACKGROUND AND AIM: Kawasaki disease is an acute systemic febrile illness of unknown aetiology, which usually affects children under 5 years of age. It is well known that Kawasaki disease is one of the most common causes of acquired heart diseases in children in the developed countries. Many studies, have suggested that heterogeneous infectious agents, such as common viruses, may trigger Kawasaki disease in young children with genetic background.  Nowadays we are facing a pandemic caused by a Novel Coronavirus named SARS-CoV-2. Consequently, it could be possible that once exposed to this new coronavirus, some children, genetically predisposed, may mount an exaggerated inflammatory response which clinically manifests as Kawasaki Disease. METHODS: from January to May 2020 a systematic search was performed on Pubmed for the following search terms: "COVID-19", "children", "SARS-CoV-2", "complications", "Kawasaki disease", "cytokine storm". RESULTS: Usually, infants and children present milder symptoms of SARS-CoV-2 disease with a better outcome than adults. At variance, some children may be genetically disposed to a more robust inflammatory response to SARS-CoV-2, similar to Kawasaki disease. In fact, Kawasaki disease is the result of an abnormal immune response, in susceptible children, to an external trigger such as an infection. Thus, according to the pathogenesis of Kawasaki disease, paediatricians may expect an increase in cases of Kawasaki disease during the COVID-19 pandemic. SN - 2531-6745 UR - https://www.unboundmedicine.com/medline/citation/32921711/An_Outbreak_of_Kawasaki_like_Disease_in_children_during_SARS_CoV__2_Epidemic:_No_Surprise L2 - https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/32921711/ DB - PRIME DP - Unbound Medicine ER -