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The "perfect" storm: Current evidence on pediatric inflammatory multisystem disease during SARS-CoV-2 pandemic.
Acta Biomed. 2020 09 07; 91(3):e2020034.AB

Abstract

Current data suggest that during the global pandemic of COVID 19 children are less affected than adults and most of them are asymptomatic or with mild symptoms. However, recently, cases of pediatric patients who have developed severe inflammatory syndrome temporally related to SARS-CoV-2 have been reported both in USA and Europe. These reports, although sharing features with other pediatric syndromes such as Kawasaki disease (KD), Kawasaki disease shock syndrome (KDSS), macrophage activated syndrome (MAS) and shock toxic syndrome (TSS), seem to outline a novel entity syndrome, characterized by cytokine storm with elevated inflammatory markers and typical clinical finding. Clinical characteristics are greater median age than KD, higher frequency of cardiac involvement and gastrointestinal symptoms, lower frequency of coronary anomalies. We report a summary of the current evidence about clinical features, pathogenesis, therapy strategies and outcome of this novel syndrome.

Authors+Show Affiliations

Pediatric Unit, Department of Medical and Surgical Sciences of the Mother, Children and Adults. University of Modena and Reggio Emilia. lami.francesca@aou.mo.it.Post-graduate school of Pediatrics, Department of Medical and Surgical Sciences of the Mother, Children and Adults. University of Modena and Reggio Emilia. ilaria.scalabrini@gmail.com.Pediatric Unit, Department of Medical and Surgical Sciences of the Mother, Children and Adults. University of Modena and Reggio Emilia, Via del Pozzo n. 71, 41124, Modena, Italy. laura.lucaccioni@unimore.it.Pediatric Unit, Department of Medical and Surgical Sciences of the Mother, Children and Adults. University of Modena and Reggio Emilia, Modena, Italy. lorenzo.iughetti@unimore.it.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

32921728

Citation

Lami, Francesca, et al. "The "perfect" Storm: Current Evidence On Pediatric Inflammatory Multisystem Disease During SARS-CoV-2 Pandemic." Acta Bio-medica : Atenei Parmensis, vol. 91, no. 3, 2020, pp. e2020034.
Lami F, Scalabrini I, Lucaccioni L, et al. The "perfect" storm: Current evidence on pediatric inflammatory multisystem disease during SARS-CoV-2 pandemic. Acta Biomed. 2020;91(3):e2020034.
Lami, F., Scalabrini, I., Lucaccioni, L., & Iughetti, L. (2020). The "perfect" storm: Current evidence on pediatric inflammatory multisystem disease during SARS-CoV-2 pandemic. Acta Bio-medica : Atenei Parmensis, 91(3), e2020034. https://doi.org/10.23750/abm.v91i3.10360
Lami F, et al. The "perfect" Storm: Current Evidence On Pediatric Inflammatory Multisystem Disease During SARS-CoV-2 Pandemic. Acta Biomed. 2020 09 7;91(3):e2020034. PubMed PMID: 32921728.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The "perfect" storm: Current evidence on pediatric inflammatory multisystem disease during SARS-CoV-2 pandemic. AU - Lami,Francesca, AU - Scalabrini,Ilaria, AU - Lucaccioni,Laura, AU - Iughetti,Lorenzo, Y1 - 2020/09/07/ PY - 2020/07/30/received PY - 2020/07/30/accepted PY - 2020/9/14/entrez PY - 2020/9/15/pubmed PY - 2020/9/23/medline SP - e2020034 EP - e2020034 JF - Acta bio-medica : Atenei Parmensis JO - Acta Biomed VL - 91 IS - 3 N2 - Current data suggest that during the global pandemic of COVID 19 children are less affected than adults and most of them are asymptomatic or with mild symptoms. However, recently, cases of pediatric patients who have developed severe inflammatory syndrome temporally related to SARS-CoV-2 have been reported both in USA and Europe. These reports, although sharing features with other pediatric syndromes such as Kawasaki disease (KD), Kawasaki disease shock syndrome (KDSS), macrophage activated syndrome (MAS) and shock toxic syndrome (TSS), seem to outline a novel entity syndrome, characterized by cytokine storm with elevated inflammatory markers and typical clinical finding. Clinical characteristics are greater median age than KD, higher frequency of cardiac involvement and gastrointestinal symptoms, lower frequency of coronary anomalies. We report a summary of the current evidence about clinical features, pathogenesis, therapy strategies and outcome of this novel syndrome. SN - 2531-6745 UR - https://www.unboundmedicine.com/medline/citation/32921728/The_"perfect"_storm:_Current_evidence_on_pediatric_inflammatory_multisystem_disease_during_SARS_CoV_2_pandemic_ L2 - https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/32921728/ DB - PRIME DP - Unbound Medicine ER -