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The Comparative Immunological Characteristics of SARS-CoV, MERS-CoV, and SARS-CoV-2 Coronavirus Infections.
Front Immunol. 2020; 11:2033.FI

Abstract

Immune dysfunction and aberrant cytokine storms often lead to rapid exacerbation of the disease during late infection stages in SARS-CoV and MERS-CoV patients. However, the underlying immunopathology mechanisms are not fully understood, and there has been little progress in research regarding the development of vaccines, anti-viral drugs, and immunotherapy. The newly discovered SARS-CoV-2 (2019-nCoV) is responsible for the third coronavirus pandemic in the human population, and this virus exhibits enhanced pathogenicity and transmissibility. SARS-CoV-2 is highly genetically homologous to SARS-CoV, and infection may result in a similar clinical disease (COVID-19). In this review, we provide detailed knowledge of the pathogenesis and immunological characteristics of SARS and MERS, and we present recent findings regarding the clinical features and potential immunopathogenesis of COVID-19. Host immunological characteristics of these three infections are summarised and compared. We aim to provide insights and scientific evidence regarding the pathogenesis of COVID-19 and therapeutic strategies targeting this disease.

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Authors+Show Affiliations

Zhang YY
Department of Paediatric Intensive Care Unit, Shanghai Children's Medical Center, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.
Li BR
Department of Paediatric Intensive Care Unit, Shanghai Children's Medical Center, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.
Ning BT
Department of Paediatric Intensive Care Unit, Shanghai Children's Medical Center, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.

MeSH

BetacoronavirusCOVID-19Coronavirus InfectionsCytokine Release SyndromeHumansMiddle East Respiratory Syndrome CoronavirusPandemicsPneumonia, ViralSevere acute respiratory syndrome-related coronavirusSARS-CoV-2Severe Acute Respiratory Syndrome

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

32922406

Citation

Zhang, Yun-Yu, et al. "The Comparative Immunological Characteristics of SARS-CoV, MERS-CoV, and SARS-CoV-2 Coronavirus Infections." Frontiers in Immunology, vol. 11, 2020, p. 2033.
Zhang YY, Li BR, Ning BT. The Comparative Immunological Characteristics of SARS-CoV, MERS-CoV, and SARS-CoV-2 Coronavirus Infections. Front Immunol. 2020;11:2033.
Zhang, Y. Y., Li, B. R., & Ning, B. T. (2020). The Comparative Immunological Characteristics of SARS-CoV, MERS-CoV, and SARS-CoV-2 Coronavirus Infections. Frontiers in Immunology, 11, 2033. https://doi.org/10.3389/fimmu.2020.02033
Zhang YY, Li BR, Ning BT. The Comparative Immunological Characteristics of SARS-CoV, MERS-CoV, and SARS-CoV-2 Coronavirus Infections. Front Immunol. 2020;11:2033. PubMed PMID: 32922406.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The Comparative Immunological Characteristics of SARS-CoV, MERS-CoV, and SARS-CoV-2 Coronavirus Infections. AU - Zhang,Yun-Yu, AU - Li,Bi-Ru, AU - Ning,Bo-Tao, Y1 - 2020/08/14/ PY - 2020/05/18/received PY - 2020/07/27/accepted PY - 2020/9/14/entrez PY - 2020/9/15/pubmed PY - 2020/9/29/medline KW - MERS-CoV KW - SARS-CoV KW - SARS-CoV-2 KW - immunology KW - novel coronavirus SP - 2033 EP - 2033 JF - Frontiers in immunology JO - Front Immunol VL - 11 N2 - Immune dysfunction and aberrant cytokine storms often lead to rapid exacerbation of the disease during late infection stages in SARS-CoV and MERS-CoV patients. However, the underlying immunopathology mechanisms are not fully understood, and there has been little progress in research regarding the development of vaccines, anti-viral drugs, and immunotherapy. The newly discovered SARS-CoV-2 (2019-nCoV) is responsible for the third coronavirus pandemic in the human population, and this virus exhibits enhanced pathogenicity and transmissibility. SARS-CoV-2 is highly genetically homologous to SARS-CoV, and infection may result in a similar clinical disease (COVID-19). In this review, we provide detailed knowledge of the pathogenesis and immunological characteristics of SARS and MERS, and we present recent findings regarding the clinical features and potential immunopathogenesis of COVID-19. Host immunological characteristics of these three infections are summarised and compared. We aim to provide insights and scientific evidence regarding the pathogenesis of COVID-19 and therapeutic strategies targeting this disease. SN - 1664-3224 UR - https://www.unboundmedicine.com/medline/citation/32922406/The_Comparative_Immunological_Characteristics_of_SARS_CoV_MERS_CoV_and_SARS_CoV_2_Coronavirus_Infections_ DB - PRIME DP - Unbound Medicine ER -