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Characterization of Severe Acute Respiratory Syndrome Coronavirus 2 Stability in Multiple Water Matrices.
J Korean Med Sci. 2020 09 14 [Online ahead of print]JK

Abstract

The advent of the global pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) necessitates a thorough study of the stability and transmissibility in the environment. We characterized the stability of SARS-CoV-2 in three water matrices: fresh, tap, and seawater. The minimum infective dose of SARS-CoV-2 in Vero cells was confirmed to be 10³ PFU/mL. The stability of SARS-CoV-2 varied according to the water matrix: infective SARS-CoV-2 was undetectable after treatment with fresh water and seawater, but remained detectable for 2 days in tap water, when starting with an initial concentration of 10⁴ PFU/mL. When the starting concentration was increased to 10⁵ PFU/mL, a similar trend was observed. In addition, viral RNA persisted longer than infectious virus in all water matrices. This study was conducted in stagnant water containing a significantly high titer of virus, thus, human-to-human transmission of SARS-CoV-2 through the actual aquatic environment is expected to be rare.

Authors+Show Affiliations

Division of Viral Disease Research, Center for Infectious Diseases Research, National Institute of Health, Korea Centers for Disease Control and Prevention, Cheongju, Korea.Division of Viral Disease Research, Center for Infectious Diseases Research, National Institute of Health, Korea Centers for Disease Control and Prevention, Cheongju, Korea.Division of Viral Disease Research, Center for Infectious Diseases Research, National Institute of Health, Korea Centers for Disease Control and Prevention, Cheongju, Korea.Division of Viral Disease Research, Center for Infectious Diseases Research, National Institute of Health, Korea Centers for Disease Control and Prevention, Cheongju, Korea.Division of Viral Disease Research, Center for Infectious Diseases Research, National Institute of Health, Korea Centers for Disease Control and Prevention, Cheongju, Korea. woojusun012@korea.kr.

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

32924345

Citation

Lee, Young Jae, et al. "Characterization of Severe Acute Respiratory Syndrome Coronavirus 2 Stability in Multiple Water Matrices." Journal of Korean Medical Science, 2020.
Lee YJ, Kim JH, Choi BS, et al. Characterization of Severe Acute Respiratory Syndrome Coronavirus 2 Stability in Multiple Water Matrices. J Korean Med Sci. 2020.
Lee, Y. J., Kim, J. H., Choi, B. S., Choi, J. H., & Jeong, Y. I. (2020). Characterization of Severe Acute Respiratory Syndrome Coronavirus 2 Stability in Multiple Water Matrices. Journal of Korean Medical Science.
Lee YJ, et al. Characterization of Severe Acute Respiratory Syndrome Coronavirus 2 Stability in Multiple Water Matrices. J Korean Med Sci. 2020 09 14;. PubMed PMID: 32924345.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Characterization of Severe Acute Respiratory Syndrome Coronavirus 2 Stability in Multiple Water Matrices. AU - Lee,Young Jae, AU - Kim,Je Hyoung, AU - Choi,Byeong Sun, AU - Choi,Jang Hoon, AU - Jeong,Young Il, Y1 - 2020/09/14/ PY - 2020/07/08/received PY - 2020/08/26/accepted PY - 2020/9/14/entrez PY - 2020/9/15/pubmed PY - 2020/9/20/medline KW - Coronavirus KW - SARS-CoV-2 KW - Virus Inactivation KW - Water Stability SP - EP - JF - Journal of Korean medical science JO - J Korean Med Sci N2 - The advent of the global pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) necessitates a thorough study of the stability and transmissibility in the environment. We characterized the stability of SARS-CoV-2 in three water matrices: fresh, tap, and seawater. The minimum infective dose of SARS-CoV-2 in Vero cells was confirmed to be 10³ PFU/mL. The stability of SARS-CoV-2 varied according to the water matrix: infective SARS-CoV-2 was undetectable after treatment with fresh water and seawater, but remained detectable for 2 days in tap water, when starting with an initial concentration of 10⁴ PFU/mL. When the starting concentration was increased to 10⁵ PFU/mL, a similar trend was observed. In addition, viral RNA persisted longer than infectious virus in all water matrices. This study was conducted in stagnant water containing a significantly high titer of virus, thus, human-to-human transmission of SARS-CoV-2 through the actual aquatic environment is expected to be rare. SN - 1598-6357 UR - https://www.unboundmedicine.com/medline/citation/32924345/Characterization_of_Severe_Acute_Respiratory_Syndrome_Coronavirus_2_Stability_in_Multiple_Water_Matrices_ L2 - https://medlineplus.gov/drinkingwater.html DB - PRIME DP - Unbound Medicine ER -