TY - JOUR T1 - An evidence-based systematic review on emerging therapeutic and preventive strategies to treat novel coronavirus (SARS-CoV-2) during an outbreak scenario. AU - Gudadappanavar,Anupama M, AU - Benni,Jyoti, Y1 - 2020/09/14/ PY - 2020/04/23/received PY - 2020/07/19/accepted PY - 2020/9/15/pubmed PY - 2020/11/20/medline PY - 2020/9/14/entrez KW - SARS CoV-2 KW - antiviral drugs KW - coronavirus KW - vaccines JF - Journal of basic and clinical physiology and pharmacology JO - J Basic Clin Physiol Pharmacol VL - 31 IS - 6 N2 - A novel coronavirus infection coronavirus disease 2019 (COVID-19) emerged from Wuhan, Hubei Province of China, in December 2019 caused by SARS-CoV-2 is believed to be originated from bats in the local wet markets. Later, animal to human and human-to-human transmission of the virus began and resulting in widespread respiratory illness worldwide to around more than 180 countries. The World Health Organization declared this disease as a pandemic in March 2020. There is no clinically approved antiviral drug or vaccine available to be used against COVID-19. Nevertheless, few broad-spectrum antiviral drugs have been studied against COVID-19 in clinical trials with clinical recovery. In the current review, we summarize the morphology and pathogenesis of COVID-19 infection. A strong rational groundwork was made keeping the focus on current development of therapeutic agents and vaccines for SARS-CoV-2. Among the proposed therapeutic regimen, hydroxychloroquine, chloroquine, remdisevir, azithromycin, toclizumab and cromostat mesylate have shown promising results, and limited benefit was seen with lopinavir-ritonavir treatment in hospitalized adult patients with severe COVID-19. Early development of SARS-CoV-2 vaccine started based on the full-length genome analysis of severe acute respiratory syndrome coronavirus. Several subunit vaccines, peptides, nucleic acids, plant-derived, recombinant vaccines are under pipeline. This article concludes and highlights ongoing advances in drug repurposing, therapeutics and vaccines to counter COVID-19, which collectively could enable efforts to halt the pandemic virus infection. SN - 2191-0286 UR - https://www.unboundmedicine.com/medline/citation/32924964/An_evidence_based_systematic_review_on_emerging_therapeutic_and_preventive_strategies_to_treat_novel_coronavirus__SARS_CoV_2__during_an_outbreak_scenario_ DB - PRIME DP - Unbound Medicine ER -