TY - JOUR T1 - Aluminum and Neurofibrillary Tangle Co-Localization in Familial Alzheimer's Disease and Related Neurological Disorders. AU - Mold,Matthew John, AU - O'Farrell,Adam, AU - Morris,Benjamin, AU - Exley,Christopher, PY - 2020/9/15/pubmed PY - 2021/9/21/medline PY - 2020/9/14/entrez KW - Parkinson’s disease KW - aluminum in human brain tissue KW - amyloid-β KW - epilepsy KW - familial Alzheimer’s disease KW - tau KW - α-synuclein SP - 139 EP - 149 JF - Journal of Alzheimer's disease : JAD JO - J Alzheimers Dis VL - 78 IS - 1 N2 - BACKGROUND: Protein misfolding disorders are frequently implicated in neurodegenerative conditions. Familial Alzheimer's disease (fAD) is an early-onset and aggressive form of Alzheimer's disease (AD), driven through autosomal dominant mutations in genes encoding the amyloid precursor protein and presenilins 1 and 2. The incidence of epilepsy is higher in AD patients with shared neuropathological hallmarks in both disease states, including the formation of neurofibrillary tangles. Similarly, in Parkinson's disease, dementia onset is known to follow neurofibrillary tangle deposition. OBJECTIVE: Human exposure to aluminum has been linked to the etiology of neurodegenerative conditions and recent studies have demonstrated a high level of co-localization between amyloid-β and aluminum in fAD. In contrast, in a donor exposed to high levels of aluminum later developing late-onset epilepsy, aluminum and neurofibrillary tangles were found to deposit independently. Herein, we sought to identify aluminum and neurofibrillary tangles in fAD, Parkinson's disease, and epilepsy donors. METHODS: Aluminum-specific fluorescence microscopy was used to identify aluminum in neurofibrillary tangles in human brain tissue. RESULTS: We observed aluminum and neurofibrillary-like tangles in identical cells in all respective disease states. Co-deposition varied across brain regions, with aluminum and neurofibrillary tangles depositing in different cellular locations of the same cell. CONCLUSION: Neurofibrillary tangle deposition closely follows cognitive-decline, and in epilepsy, tau phosphorylation associates with increased mossy fiber sprouting and seizure onset. Therefore, the presence of aluminum in these cells may exacerbate the accumulation and misfolding of amyloidogenic proteins including hyperphosphorylated tau in fAD, epilepsy, and Parkinson's disease. SN - 1875-8908 UR - https://www.unboundmedicine.com/medline/citation/32925074/Aluminum_and_Neurofibrillary_Tangle_Co_Localization_in_Familial_Alzheimer's_Disease_and_Related_Neurological_Disorders_ DB - PRIME DP - Unbound Medicine ER -