Tags

Type your tag names separated by a space and hit enter

A Systematic Review of Multisystem Inflammatory Syndrome in Children Associated With SARS-CoV-2 Infection.
Pediatr Infect Dis J. 2020 11; 39(11):e340-e346.PI

Abstract

BACKGROUND

Recently, severe manifestations associated with coronavirus disease 2019 (COVID-19) called multisystem inflammatory syndrome in children (MIS-C) have been recognized. Analysis of studies for this novel syndrome is needed for a better understanding of effective management among affected children.

METHODS

An extensive search strategy was conducted by combining the terms multisystem inflammatory syndrome in children and coronavirus infection or using the term multisystem inflammatory syndrome in children in bibliographic electronic databases (PubMed, EMBASE, and CINAHL) and in preprint servers (BioRxiv.org and MedRxiv.org) following the Preferred Reporting Items for Systematic Reviews and Metaanalyses guidelines to retrieve all articles published from January 1, 2020, to July 31, 2020. Observational cross-sectional, cohort, case series, and case reports were included.

RESULTS

A total of 328 articles were identified. Sixteen studies with 655 participants (3 months-20 years of age) were included in the final analysis. Most of the children in reported studies presented with fever, gastrointestinal symptoms, and Kawasaki Disease-like symptoms. Sixty-eight percent of the patients required critical care; 40% needed inotropes; 34% received anticoagulation; and 15% required mechanical ventilation. More than two-thirds of the patients received intravenous immunoglobulin and 49% received corticosteroids. Remdesivir and convalescent plasma were the least commonly utilized therapies. Left ventricular dysfunction was reported in 32% of patients. Among patients presenting with KD-like symptoms, 23% developed coronary abnormalities and 26% had circulatory shock. The majority recovered; 11 (1.7%) children died.

CONCLUSIONS

This systematic review delineates and summarizes clinical features, management, and outcomes of MIS-C associated with SARS-CoV-2 infection. Although most children required intensive care and immunomodulatory therapies, favorable outcomes were reported in the majority with low-mortality rates.

Authors+Show Affiliations

From the Division of Pediatric Infectious Diseases, UnityPoint Health at St. Luke's Regional Medical Center and Department of Pediatrics, University of Iowa Carver College of Medicine.Division of Pulmonary and Critical Care, UnityPoint Health at St. Luke's Regional Medical Center, Sioux City, Iowa.Department of Pediatrics, Indira Gandhi Medical College, Shimla.Department of Pediatrics, Dr. Rajendra Prasad Government Medical College, Kangra, Himachal Pradesh, India.Department of Pediatrics, Dr. Rajendra Prasad Government Medical College, Kangra, Himachal Pradesh, India.

Pub Type(s)

Journal Article
Systematic Review

Language

eng

PubMed ID

32925547

Citation

Kaushik, Ashlesha, et al. "A Systematic Review of Multisystem Inflammatory Syndrome in Children Associated With SARS-CoV-2 Infection." The Pediatric Infectious Disease Journal, vol. 39, no. 11, 2020, pp. e340-e346.
Kaushik A, Gupta S, Sood M, et al. A Systematic Review of Multisystem Inflammatory Syndrome in Children Associated With SARS-CoV-2 Infection. Pediatr Infect Dis J. 2020;39(11):e340-e346.
Kaushik, A., Gupta, S., Sood, M., Sharma, S., & Verma, S. (2020). A Systematic Review of Multisystem Inflammatory Syndrome in Children Associated With SARS-CoV-2 Infection. The Pediatric Infectious Disease Journal, 39(11), e340-e346. https://doi.org/10.1097/INF.0000000000002888
Kaushik A, et al. A Systematic Review of Multisystem Inflammatory Syndrome in Children Associated With SARS-CoV-2 Infection. Pediatr Infect Dis J. 2020;39(11):e340-e346. PubMed PMID: 32925547.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A Systematic Review of Multisystem Inflammatory Syndrome in Children Associated With SARS-CoV-2 Infection. AU - Kaushik,Ashlesha, AU - Gupta,Sandeep, AU - Sood,Mangla, AU - Sharma,Seema, AU - Verma,Shikha, PY - 2020/9/15/pubmed PY - 2020/11/5/medline PY - 2020/9/14/entrez SP - e340 EP - e346 JF - The Pediatric infectious disease journal JO - Pediatr Infect Dis J VL - 39 IS - 11 N2 - BACKGROUND: Recently, severe manifestations associated with coronavirus disease 2019 (COVID-19) called multisystem inflammatory syndrome in children (MIS-C) have been recognized. Analysis of studies for this novel syndrome is needed for a better understanding of effective management among affected children. METHODS: An extensive search strategy was conducted by combining the terms multisystem inflammatory syndrome in children and coronavirus infection or using the term multisystem inflammatory syndrome in children in bibliographic electronic databases (PubMed, EMBASE, and CINAHL) and in preprint servers (BioRxiv.org and MedRxiv.org) following the Preferred Reporting Items for Systematic Reviews and Metaanalyses guidelines to retrieve all articles published from January 1, 2020, to July 31, 2020. Observational cross-sectional, cohort, case series, and case reports were included. RESULTS: A total of 328 articles were identified. Sixteen studies with 655 participants (3 months-20 years of age) were included in the final analysis. Most of the children in reported studies presented with fever, gastrointestinal symptoms, and Kawasaki Disease-like symptoms. Sixty-eight percent of the patients required critical care; 40% needed inotropes; 34% received anticoagulation; and 15% required mechanical ventilation. More than two-thirds of the patients received intravenous immunoglobulin and 49% received corticosteroids. Remdesivir and convalescent plasma were the least commonly utilized therapies. Left ventricular dysfunction was reported in 32% of patients. Among patients presenting with KD-like symptoms, 23% developed coronary abnormalities and 26% had circulatory shock. The majority recovered; 11 (1.7%) children died. CONCLUSIONS: This systematic review delineates and summarizes clinical features, management, and outcomes of MIS-C associated with SARS-CoV-2 infection. Although most children required intensive care and immunomodulatory therapies, favorable outcomes were reported in the majority with low-mortality rates. SN - 1532-0987 UR - https://www.unboundmedicine.com/medline/citation/32925547/A_Systematic_Review_of_Multisystem_Inflammatory_Syndrome_in_Children_Associated_With_SARS_CoV_2_Infection_ L2 - https://doi.org/10.1097/INF.0000000000002888 DB - PRIME DP - Unbound Medicine ER -