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Mass Spectrometry and Structural Biology Techniques in the Studies on the Coronavirus-Receptor Interaction.
Molecules. 2020 Sep 10; 25(18)M

Abstract

Mass spectrometry and some other biophysical methods, have made substantial contributions to the studies on severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and human proteins interactions. The most interesting feature of SARS-CoV-2 seems to be the structure of its spike (S) protein and its interaction with the human cell receptor. Mass spectrometry of spike S protein revealed how the glycoforms are distributed across the S protein surface. X-ray crystallography and cryo-electron microscopy made huge impact on the studies on the S protein and ACE2 receptor protein interaction, by elucidating the three-dimensional structures of these proteins and their conformational changes. The findings of the most recent studies in the scope of SARS-CoV-2-Human protein-protein interactions are described here.

Authors+Show Affiliations

Institute of Health Sciences, Opole University, Katowicka 68, 45-060 Opole, Poland.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

32927621

Citation

Witkowska, Danuta. "Mass Spectrometry and Structural Biology Techniques in the Studies On the Coronavirus-Receptor Interaction." Molecules (Basel, Switzerland), vol. 25, no. 18, 2020.
Witkowska D. Mass Spectrometry and Structural Biology Techniques in the Studies on the Coronavirus-Receptor Interaction. Molecules. 2020;25(18).
Witkowska, D. (2020). Mass Spectrometry and Structural Biology Techniques in the Studies on the Coronavirus-Receptor Interaction. Molecules (Basel, Switzerland), 25(18). https://doi.org/10.3390/molecules25184133
Witkowska D. Mass Spectrometry and Structural Biology Techniques in the Studies On the Coronavirus-Receptor Interaction. Molecules. 2020 Sep 10;25(18) PubMed PMID: 32927621.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Mass Spectrometry and Structural Biology Techniques in the Studies on the Coronavirus-Receptor Interaction. A1 - Witkowska,Danuta, Y1 - 2020/09/10/ PY - 2020/08/01/received PY - 2020/09/01/revised PY - 2020/09/09/accepted PY - 2020/9/15/entrez PY - 2020/9/16/pubmed PY - 2020/9/24/medline KW - MS KW - SARS coronavirus KW - glycosylation KW - spike protein-ACE2 interaction KW - structural techniques JF - Molecules (Basel, Switzerland) JO - Molecules VL - 25 IS - 18 N2 - Mass spectrometry and some other biophysical methods, have made substantial contributions to the studies on severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and human proteins interactions. The most interesting feature of SARS-CoV-2 seems to be the structure of its spike (S) protein and its interaction with the human cell receptor. Mass spectrometry of spike S protein revealed how the glycoforms are distributed across the S protein surface. X-ray crystallography and cryo-electron microscopy made huge impact on the studies on the S protein and ACE2 receptor protein interaction, by elucidating the three-dimensional structures of these proteins and their conformational changes. The findings of the most recent studies in the scope of SARS-CoV-2-Human protein-protein interactions are described here. SN - 1420-3049 UR - https://www.unboundmedicine.com/medline/citation/32927621/Mass_Spectrometry_and_Structural_Biology_Techniques_in_the_Studies_on_the_Coronavirus_Receptor_Interaction_ L2 - https://www.mdpi.com/resolver?pii=molecules25184133 DB - PRIME DP - Unbound Medicine ER -