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Vitamin D Deficiency and Outcome of COVID-19 Patients.
Nutrients. 2020 Sep 10; 12(9)N

Abstract

Infection with the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) poses an enormous challenge to health care systems throughout the world. Without causal treatment, identification of modifiable prognostic factors may help to improve outcomes. To explore possible associations of vitamin D (VitD) status with disease severity and survival, we studied 185 patients diagnosed with coronavirus disease 2019 (COVID-19) and treated at our center. VitD status at first presentation was assessed retrospectively using accredited laboratory methods. VitD deficiency was defined as serum total 25-hydroxyvitamin D level < 12 ng/mL (<30 nM). Primary endpoint was severe course of disease (i.e., need for invasive mechanical ventilation and/or death, IMV/D). Within a median observation period of 66 days (range 2-92), 23 patients required IMV. A total of 28 patients had IMV/D, including 16 deaths. Ninety-three (50%) patients required hospitalization (inpatient subgroup). A total of 41 (22%) patients were VitD deficient. When adjusted for age, gender, and comorbidities, VitD deficiency was associated with higher risk of IMV/D and death (HR 6.12, 95% CI 2.79-13.42, p < 0.001 and HR 14.73, 95% CI 4.16-52.19, p < 0.001, respectively). Similar correlations were observed in the inpatient subgroup. Our study demonstrates an association between VitD deficiency and severity/mortality of COVID-19, highlighting the need for interventional studies on VitD supplementation in SARS-CoV-2 infected individuals.

Authors+Show Affiliations

Department of Internal Medicine V, University of Heidelberg, 69121 Heidelberg, Germany.Department of Internal Medicine IV, University of Heidelberg, 69121 Heidelberg, Germany.Department of Internal Medicine IV, University of Heidelberg, 69121 Heidelberg, Germany.Department of Internal Medicine IV, University of Heidelberg, 69121 Heidelberg, Germany.Department of Internal Medicine IV, University of Heidelberg, 69121 Heidelberg, Germany.Department of Internal Medicine IV, University of Heidelberg, 69121 Heidelberg, Germany.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

32927735

Citation

Radujkovic, Aleksandar, et al. "Vitamin D Deficiency and Outcome of COVID-19 Patients." Nutrients, vol. 12, no. 9, 2020.
Radujkovic A, Hippchen T, Tiwari-Heckler S, et al. Vitamin D Deficiency and Outcome of COVID-19 Patients. Nutrients. 2020;12(9).
Radujkovic, A., Hippchen, T., Tiwari-Heckler, S., Dreher, S., Boxberger, M., & Merle, U. (2020). Vitamin D Deficiency and Outcome of COVID-19 Patients. Nutrients, 12(9). https://doi.org/10.3390/nu12092757
Radujkovic A, et al. Vitamin D Deficiency and Outcome of COVID-19 Patients. Nutrients. 2020 Sep 10;12(9) PubMed PMID: 32927735.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Vitamin D Deficiency and Outcome of COVID-19 Patients. AU - Radujkovic,Aleksandar, AU - Hippchen,Theresa, AU - Tiwari-Heckler,Shilpa, AU - Dreher,Saida, AU - Boxberger,Monica, AU - Merle,Uta, Y1 - 2020/09/10/ PY - 2020/08/09/received PY - 2020/09/01/revised PY - 2020/09/09/accepted PY - 2020/9/15/entrez PY - 2020/9/16/pubmed PY - 2020/9/25/medline KW - COVID-19 KW - SARS-CoV-2 KW - outcome KW - retrospective KW - severity KW - vitamin D JF - Nutrients JO - Nutrients VL - 12 IS - 9 N2 - Infection with the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) poses an enormous challenge to health care systems throughout the world. Without causal treatment, identification of modifiable prognostic factors may help to improve outcomes. To explore possible associations of vitamin D (VitD) status with disease severity and survival, we studied 185 patients diagnosed with coronavirus disease 2019 (COVID-19) and treated at our center. VitD status at first presentation was assessed retrospectively using accredited laboratory methods. VitD deficiency was defined as serum total 25-hydroxyvitamin D level < 12 ng/mL (<30 nM). Primary endpoint was severe course of disease (i.e., need for invasive mechanical ventilation and/or death, IMV/D). Within a median observation period of 66 days (range 2-92), 23 patients required IMV. A total of 28 patients had IMV/D, including 16 deaths. Ninety-three (50%) patients required hospitalization (inpatient subgroup). A total of 41 (22%) patients were VitD deficient. When adjusted for age, gender, and comorbidities, VitD deficiency was associated with higher risk of IMV/D and death (HR 6.12, 95% CI 2.79-13.42, p < 0.001 and HR 14.73, 95% CI 4.16-52.19, p < 0.001, respectively). Similar correlations were observed in the inpatient subgroup. Our study demonstrates an association between VitD deficiency and severity/mortality of COVID-19, highlighting the need for interventional studies on VitD supplementation in SARS-CoV-2 infected individuals. SN - 2072-6643 UR - https://www.unboundmedicine.com/medline/citation/32927735/Vitamin_D_Deficiency_and_Outcome_of_COVID_19_Patients_ L2 - https://www.mdpi.com/resolver?pii=nu12092757 DB - PRIME DP - Unbound Medicine ER -