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Quantification Analysis of 13 Organic Components and 8 Inorganic Elements in Angelica Sinensis Radix and Its Different Parts Combined with Chemical Recognition Pattern.
J Anal Methods Chem. 2020; 2020:8836184.JA

Abstract

Angelica Sinensis Radix (Danggui, DG) is one of the most commonly prescribed traditional Chinese medicines. The organic components include phthalides and phenolic acids. Meanwhile, inorganic elements play an important role in clinical effect. DG and its different parts have different effects. There is no relevant report on the analysis of organic compounds and inorganic elements among them. Therefore, ultra-high-performance liquid chromatography coupled with triple quadrupole mass spectrometry was developed for the simultaneous determination of 13 organic components (8 phthalides and 5 phenolic acids), and 8 inorganic elements were determined by inductively coupled plasma mass spectrometry. The contents of 32 samples were analyzed by orthogonal partial least squares discrimination analysis, hierarchical cluster analysis, and least-significant difference of one-way analysis of variance. The results showed that the differences were significant among DG and its different parts. 11 difference markers (Ca, Z-ligustilide, Mg, Mn, Fe, Na, K, Cu, Zn, coniferyl ferulate, and senkyunolide A) were obtained by variable importance for the project. These difference markers were some different among DG and its different parts, especially Z-ligustilide, coniferyl ferulate, Mg, Zn, the differences were significant. This study can provide a reference for DG research.

Authors+Show Affiliations

Sichuan Institute for Food and Drug Control, Chengdu 611730, China.Kangmei Pharmaceutical Co., Ltd., Shenzhen 518000, China.Deyang Food and Drug Safety Inspection and Testing Center, Deyang 618000, China.School of Pharmacy, Fujian University of Traditional Chinese Medicine, Fuzhou 350122, China.Sichuan Institute for Food and Drug Control, Chengdu 611730, China.Affiliated Hospital, Leshan Normal University, Leshan 614004, China.Deyang Food and Drug Safety Inspection and Testing Center, Deyang 618000, China.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

32934860

Citation

Li, Xi, et al. "Quantification Analysis of 13 Organic Components and 8 Inorganic Elements in Angelica Sinensis Radix and Its Different Parts Combined With Chemical Recognition Pattern." Journal of Analytical Methods in Chemistry, vol. 2020, 2020, p. 8836184.
Li X, Yao Y, Wang X, et al. Quantification Analysis of 13 Organic Components and 8 Inorganic Elements in Angelica Sinensis Radix and Its Different Parts Combined with Chemical Recognition Pattern. J Anal Methods Chem. 2020;2020:8836184.
Li, X., Yao, Y., Wang, X., An, C., Gao, S., Xiang, F., & Dong, Y. (2020). Quantification Analysis of 13 Organic Components and 8 Inorganic Elements in Angelica Sinensis Radix and Its Different Parts Combined with Chemical Recognition Pattern. Journal of Analytical Methods in Chemistry, 2020, 8836184. https://doi.org/10.1155/2020/8836184
Li X, et al. Quantification Analysis of 13 Organic Components and 8 Inorganic Elements in Angelica Sinensis Radix and Its Different Parts Combined With Chemical Recognition Pattern. J Anal Methods Chem. 2020;2020:8836184. PubMed PMID: 32934860.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Quantification Analysis of 13 Organic Components and 8 Inorganic Elements in Angelica Sinensis Radix and Its Different Parts Combined with Chemical Recognition Pattern. AU - Li,Xi, AU - Yao,Yixin, AU - Wang,Xiaoxiao, AU - An,Chang, AU - Gao,Shanshan, AU - Xiang,Fangtao, AU - Dong,Yangli, Y1 - 2020/08/31/ PY - 2020/04/16/received PY - 2020/08/04/revised PY - 2020/08/19/accepted PY - 2020/9/16/entrez PY - 2020/9/17/pubmed PY - 2020/9/17/medline SP - 8836184 EP - 8836184 JF - Journal of analytical methods in chemistry JO - J Anal Methods Chem VL - 2020 N2 - Angelica Sinensis Radix (Danggui, DG) is one of the most commonly prescribed traditional Chinese medicines. The organic components include phthalides and phenolic acids. Meanwhile, inorganic elements play an important role in clinical effect. DG and its different parts have different effects. There is no relevant report on the analysis of organic compounds and inorganic elements among them. Therefore, ultra-high-performance liquid chromatography coupled with triple quadrupole mass spectrometry was developed for the simultaneous determination of 13 organic components (8 phthalides and 5 phenolic acids), and 8 inorganic elements were determined by inductively coupled plasma mass spectrometry. The contents of 32 samples were analyzed by orthogonal partial least squares discrimination analysis, hierarchical cluster analysis, and least-significant difference of one-way analysis of variance. The results showed that the differences were significant among DG and its different parts. 11 difference markers (Ca, Z-ligustilide, Mg, Mn, Fe, Na, K, Cu, Zn, coniferyl ferulate, and senkyunolide A) were obtained by variable importance for the project. These difference markers were some different among DG and its different parts, especially Z-ligustilide, coniferyl ferulate, Mg, Zn, the differences were significant. This study can provide a reference for DG research. SN - 2090-8865 UR - https://www.unboundmedicine.com/medline/citation/32934860/Quantification_Analysis_of_13_Organic_Components_and_8_Inorganic_Elements_in_Angelica_Sinensis_Radix_and_Its_Different_Parts_Combined_with_Chemical_Recognition_Pattern. L2 - https://doi.org/10.1155/2020/8836184 DB - PRIME DP - Unbound Medicine ER -
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