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The Effects of Cannabidiol, a Non-Intoxicating Compound of Cannabis, on the Cardiovascular System in Health and Disease.
Int J Mol Sci. 2020 Sep 14; 21(18)IJ

Abstract

Cannabidiol (CBD) is a non-intoxicating and generally well-tolerated constituent of cannabis which exhibits potential beneficial properties in a wide range of diseases, including cardiovascular disorders. Due to its complex mechanism of action, CBD may affect the cardiovascular system in different ways. Thus, we reviewed the influence of CBD on this system in health and disease to determine the potential risk of cardiovascular side effects during CBD use for medical and wellness purposes and to elucidate its therapeutic potential in cardiovascular diseases. Administration of CBD to healthy volunteers or animals usually does not markedly affect hemodynamic parameters. Although CBD has been found to exhibit vasodilatory and antioxidant properties in hypertension, it has not affected blood pressure in hypertensive animals. Hypotensive action of CBD has been mainly revealed under stress conditions. Many positive effects of CBD have been observed in experimental models of heart diseases (myocardial infarction, cardiomyopathy, myocarditis), stroke, neonatal hypoxic ischemic encephalopathy, sepsis-related encephalitis, cardiovascular complications of diabetes, and ischemia/reperfusion injures of liver and kidneys. In these pathological conditions CBD decreased organ damage and dysfunction, oxidative and nitrative stress, inflammatory processes and apoptosis, among others. Nevertheless, further clinical research is needed to recommend the use of CBD in the treatment of cardiovascular diseases.

Authors+Show Affiliations

Department of Experimental Physiology and Pathophysiology, Medical University of Białystok, 15-222 Białystok, Poland.Department of Experimental Physiology and Pathophysiology, Medical University of Białystok, 15-222 Białystok, Poland.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

32937917

Citation

Kicman, Aleksandra, and Marek Toczek. "The Effects of Cannabidiol, a Non-Intoxicating Compound of Cannabis, On the Cardiovascular System in Health and Disease." International Journal of Molecular Sciences, vol. 21, no. 18, 2020.
Kicman A, Toczek M. The Effects of Cannabidiol, a Non-Intoxicating Compound of Cannabis, on the Cardiovascular System in Health and Disease. Int J Mol Sci. 2020;21(18).
Kicman, A., & Toczek, M. (2020). The Effects of Cannabidiol, a Non-Intoxicating Compound of Cannabis, on the Cardiovascular System in Health and Disease. International Journal of Molecular Sciences, 21(18). https://doi.org/10.3390/ijms21186740
Kicman A, Toczek M. The Effects of Cannabidiol, a Non-Intoxicating Compound of Cannabis, On the Cardiovascular System in Health and Disease. Int J Mol Sci. 2020 Sep 14;21(18) PubMed PMID: 32937917.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The Effects of Cannabidiol, a Non-Intoxicating Compound of Cannabis, on the Cardiovascular System in Health and Disease. AU - Kicman,Aleksandra, AU - Toczek,Marek, Y1 - 2020/09/14/ PY - 2020/08/08/received PY - 2020/09/09/revised PY - 2020/09/10/accepted PY - 2020/9/17/entrez PY - 2020/9/18/pubmed PY - 2021/2/25/medline KW - cannabidiol KW - cannabinoids KW - cannabis KW - cardiomyopathy KW - cardiovascular system KW - hypertension KW - ischemia KW - vasodilation JF - International journal of molecular sciences JO - Int J Mol Sci VL - 21 IS - 18 N2 - Cannabidiol (CBD) is a non-intoxicating and generally well-tolerated constituent of cannabis which exhibits potential beneficial properties in a wide range of diseases, including cardiovascular disorders. Due to its complex mechanism of action, CBD may affect the cardiovascular system in different ways. Thus, we reviewed the influence of CBD on this system in health and disease to determine the potential risk of cardiovascular side effects during CBD use for medical and wellness purposes and to elucidate its therapeutic potential in cardiovascular diseases. Administration of CBD to healthy volunteers or animals usually does not markedly affect hemodynamic parameters. Although CBD has been found to exhibit vasodilatory and antioxidant properties in hypertension, it has not affected blood pressure in hypertensive animals. Hypotensive action of CBD has been mainly revealed under stress conditions. Many positive effects of CBD have been observed in experimental models of heart diseases (myocardial infarction, cardiomyopathy, myocarditis), stroke, neonatal hypoxic ischemic encephalopathy, sepsis-related encephalitis, cardiovascular complications of diabetes, and ischemia/reperfusion injures of liver and kidneys. In these pathological conditions CBD decreased organ damage and dysfunction, oxidative and nitrative stress, inflammatory processes and apoptosis, among others. Nevertheless, further clinical research is needed to recommend the use of CBD in the treatment of cardiovascular diseases. SN - 1422-0067 UR - https://www.unboundmedicine.com/medline/citation/32937917/The_Effects_of_Cannabidiol_a_Non_Intoxicating_Compound_of_Cannabis_on_the_Cardiovascular_System_in_Health_and_Disease_ L2 - https://www.mdpi.com/resolver?pii=ijms21186740 DB - PRIME DP - Unbound Medicine ER -