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The effect of chlorhexidine and benzydamine mouthwashes on mucositis induced by therapeutic irradiation.
Clin Radiol 1988; 39(3):291-4CR

Abstract

A variety of mouthwashes are frequently used in the management of irradiation-induced mucositis. Benzydamine has recently been introduced for alleviating this condition. Its efficacy as a mouthwash was compared with chlorhexidine in two groups of patients receiving radiotherapy for oral carcinoma. Mucositis and pain were recorded over a 6 week period and oral carriage of Candida species, coliforms and Staphylococcus aureus was assessed using an oral rinse technique. There was no significant difference in the mucositis scores, overall pain scores or the yeast and bacterial species isolated between the two treatment groups. However, 58% (7 out of 12) and 92% (12 out of 13) patients reported oral discomfort when rinsing the mouth with chlorhexidine and benzydamine, respectively. In both groups, the most common coliform isolated was Klebsiella pneumoniae and the carriage of yeasts was significantly greater than that of coliforms. These results indicate that, although the individual patient acceptance of chlorhexidine is better than benzydamine, there is little difference between the two mouthwashes both in controlling pain and mucositis or in the oral carriage of the micro-organisms studied.

Authors+Show Affiliations

Department of Oral Medicine & Pathology, Glasgow Dental Hospital & School, Scotland.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

3293887

Citation

Samaranayake, L P., et al. "The Effect of Chlorhexidine and Benzydamine Mouthwashes On Mucositis Induced By Therapeutic Irradiation." Clinical Radiology, vol. 39, no. 3, 1988, pp. 291-4.
Samaranayake LP, Robertson AG, MacFarlane TW, et al. The effect of chlorhexidine and benzydamine mouthwashes on mucositis induced by therapeutic irradiation. Clin Radiol. 1988;39(3):291-4.
Samaranayake, L. P., Robertson, A. G., MacFarlane, T. W., Hunter, I. P., MacFarlane, G., Soutar, D. S., & Ferguson, M. M. (1988). The effect of chlorhexidine and benzydamine mouthwashes on mucositis induced by therapeutic irradiation. Clinical Radiology, 39(3), pp. 291-4.
Samaranayake LP, et al. The Effect of Chlorhexidine and Benzydamine Mouthwashes On Mucositis Induced By Therapeutic Irradiation. Clin Radiol. 1988;39(3):291-4. PubMed PMID: 3293887.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The effect of chlorhexidine and benzydamine mouthwashes on mucositis induced by therapeutic irradiation. AU - Samaranayake,L P, AU - Robertson,A G, AU - MacFarlane,T W, AU - Hunter,I P, AU - MacFarlane,G, AU - Soutar,D S, AU - Ferguson,M M, PY - 1988/5/1/pubmed PY - 1988/5/1/medline PY - 1988/5/1/entrez SP - 291 EP - 4 JF - Clinical radiology JO - Clin Radiol VL - 39 IS - 3 N2 - A variety of mouthwashes are frequently used in the management of irradiation-induced mucositis. Benzydamine has recently been introduced for alleviating this condition. Its efficacy as a mouthwash was compared with chlorhexidine in two groups of patients receiving radiotherapy for oral carcinoma. Mucositis and pain were recorded over a 6 week period and oral carriage of Candida species, coliforms and Staphylococcus aureus was assessed using an oral rinse technique. There was no significant difference in the mucositis scores, overall pain scores or the yeast and bacterial species isolated between the two treatment groups. However, 58% (7 out of 12) and 92% (12 out of 13) patients reported oral discomfort when rinsing the mouth with chlorhexidine and benzydamine, respectively. In both groups, the most common coliform isolated was Klebsiella pneumoniae and the carriage of yeasts was significantly greater than that of coliforms. These results indicate that, although the individual patient acceptance of chlorhexidine is better than benzydamine, there is little difference between the two mouthwashes both in controlling pain and mucositis or in the oral carriage of the micro-organisms studied. SN - 0009-9260 UR - https://www.unboundmedicine.com/medline/citation/3293887/The_effect_of_chlorhexidine_and_benzydamine_mouthwashes_on_mucositis_induced_by_therapeutic_irradiation_ L2 - https://medlineplus.gov/radiationtherapy.html DB - PRIME DP - Unbound Medicine ER -