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The Effect of One Session Split-Belt Treadmill Training on Gait Adaptation in People With Parkinson's Disease and Freezing of Gait.
Neurorehabil Neural Repair. 2020 10; 34(10):954-963.NN

Abstract

BACKGROUND

Freezing of gait (FOG) in Parkinson's disease (PD) is associated with gait asymmetry and switching difficulty. A split-belt treadmill may potentially address those deficits.

OBJECTIVE

To investigate the immediate and retention effects of one-session split-belt treadmill training (SBT) in contrast to regular tied-belt treadmill training (TBT) on gait asymmetry and adaptation in people with PD and FOG (PD + FOG) and healthy controls (HC). Additionally, to investigate differential effects of 3 SBT protocols and compare different gait adaptation outcomes.

METHODS

PD + FOG (n = 45) and HC (n = 36) were randomized to 1 of 3 SBT groups (belt speeds' ratio 0.75:1; 0.5:1 or changing ratios) or TBT group. Participants were tested at Pre, Post, and Retention after one treadmill training session. Gait asymmetry was measured during a standardized adaptation test on the split-belt treadmill.

RESULTS

SBT proved beneficial for gait adaptation in PD + FOG and HC (P < .0001); however, HC improved more. SBT with changing ratios demonstrated significant effects on gait adaptation from Pre to Post in PD + FOG, supported by strong effect sizes (d = 1.14) and improvements being retained for 24 hours. Mean step length asymmetry during initial exposure was lower in HC compared with PD + FOG (P = .035) and differentiated best between the groups.

CONCLUSIONS

PD + FOG improved gait adaptation after a single SBT session although effects were smaller than in HC. SBT with changing ratios was the most effective to ameliorate gait adaptation in PD + FOG. These promising results warrant future study on whether long-term SBT strengthens adaptation in PD + FOG and has potential to induce a better resilience to FOG. Clinical trial ID: NCT03725215.

Authors+Show Affiliations

University Hospital Schleswig-Holstein, Christian-Albrechts-University, Kiel, Germany. Christian-Albrechts-University, Kiel, Germany.Katholieke Universiteit Leuven, Leuven, Belgium.Katholieke Universiteit Leuven, Leuven, Belgium.University Hospital Schleswig-Holstein, Christian-Albrechts-University, Kiel, Germany.Christian-Albrechts-University, Kiel, Germany.Katholieke Universiteit Leuven, Leuven, Belgium.University Hospital Schleswig-Holstein, Christian-Albrechts-University, Kiel, Germany.

Pub Type(s)

Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

32940131

Citation

Seuthe, Jana, et al. "The Effect of One Session Split-Belt Treadmill Training On Gait Adaptation in People With Parkinson's Disease and Freezing of Gait." Neurorehabilitation and Neural Repair, vol. 34, no. 10, 2020, pp. 954-963.
Seuthe J, D'Cruz N, Ginis P, et al. The Effect of One Session Split-Belt Treadmill Training on Gait Adaptation in People With Parkinson's Disease and Freezing of Gait. Neurorehabil Neural Repair. 2020;34(10):954-963.
Seuthe, J., D'Cruz, N., Ginis, P., Becktepe, J. S., Weisser, B., Nieuwboer, A., & Schlenstedt, C. (2020). The Effect of One Session Split-Belt Treadmill Training on Gait Adaptation in People With Parkinson's Disease and Freezing of Gait. Neurorehabilitation and Neural Repair, 34(10), 954-963. https://doi.org/10.1177/1545968320953144
Seuthe J, et al. The Effect of One Session Split-Belt Treadmill Training On Gait Adaptation in People With Parkinson's Disease and Freezing of Gait. Neurorehabil Neural Repair. 2020;34(10):954-963. PubMed PMID: 32940131.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The Effect of One Session Split-Belt Treadmill Training on Gait Adaptation in People With Parkinson's Disease and Freezing of Gait. AU - Seuthe,Jana, AU - D'Cruz,Nicholas, AU - Ginis,Pieter, AU - Becktepe,Jos Steffen, AU - Weisser,Burkhard, AU - Nieuwboer,Alice, AU - Schlenstedt,Christian, Y1 - 2020/09/17/ PY - 2020/9/18/pubmed PY - 2021/9/10/medline PY - 2020/9/17/entrez KW - Parkinson’s disease KW - freezing of gait KW - gait adaptation KW - split-belt treadmill SP - 954 EP - 963 JF - Neurorehabilitation and neural repair JO - Neurorehabil Neural Repair VL - 34 IS - 10 N2 - BACKGROUND: Freezing of gait (FOG) in Parkinson's disease (PD) is associated with gait asymmetry and switching difficulty. A split-belt treadmill may potentially address those deficits. OBJECTIVE: To investigate the immediate and retention effects of one-session split-belt treadmill training (SBT) in contrast to regular tied-belt treadmill training (TBT) on gait asymmetry and adaptation in people with PD and FOG (PD + FOG) and healthy controls (HC). Additionally, to investigate differential effects of 3 SBT protocols and compare different gait adaptation outcomes. METHODS: PD + FOG (n = 45) and HC (n = 36) were randomized to 1 of 3 SBT groups (belt speeds' ratio 0.75:1; 0.5:1 or changing ratios) or TBT group. Participants were tested at Pre, Post, and Retention after one treadmill training session. Gait asymmetry was measured during a standardized adaptation test on the split-belt treadmill. RESULTS: SBT proved beneficial for gait adaptation in PD + FOG and HC (P < .0001); however, HC improved more. SBT with changing ratios demonstrated significant effects on gait adaptation from Pre to Post in PD + FOG, supported by strong effect sizes (d = 1.14) and improvements being retained for 24 hours. Mean step length asymmetry during initial exposure was lower in HC compared with PD + FOG (P = .035) and differentiated best between the groups. CONCLUSIONS: PD + FOG improved gait adaptation after a single SBT session although effects were smaller than in HC. SBT with changing ratios was the most effective to ameliorate gait adaptation in PD + FOG. These promising results warrant future study on whether long-term SBT strengthens adaptation in PD + FOG and has potential to induce a better resilience to FOG. Clinical trial ID: NCT03725215. SN - 1552-6844 UR - https://www.unboundmedicine.com/medline/citation/32940131/The_Effect_of_One_Session_Split_Belt_Treadmill_Training_on_Gait_Adaptation_in_People_With_Parkinson's_Disease_and_Freezing_of_Gait_ L2 - https://journals.sagepub.com/doi/10.1177/1545968320953144?url_ver=Z39.88-2003&amp;rfr_id=ori:rid:crossref.org&amp;rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -