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Combined therapy with cisapride and cimetidine in severe reflux oesophagitis: a double blind controlled trial.
Gut. 1988 May; 29(5):675-81.Gut

Abstract

Combined treatment with cimetidine 1 g daily and cisapride 40 mg daily in patients with endoscopically diagnosed severe reflux oesophagitis was compared with single drug therapy (cimetidine and placebo). At the end of the six to 12 weeks treatment, 11 (46%) of the 24 patients under single drug therapy were endoscopically healed and three were improved. In contrast, 16 (70%) of the 23 patients under combined therapy were healed and all of the remainder were improved (p = 0.025). The severity of diurnal and nocturnal heartburn, decreased significantly more (p less than 0.05) on cimetidine + cisapride than on cimetidine + placebo. The combined treatment was well tolerated. These results suggest that combined therapy with cisapride and cimetidine may be useful in patients with severe reflux oesophagitis.

Authors+Show Affiliations

Clinique des maladies de l'appareil digestif, Hôpital Guillaume et René Laennec, Nantes, France.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Controlled Clinical Trial
Journal Article

Language

eng

PubMed ID

3294124

Citation

Galmiche, J P., et al. "Combined Therapy With Cisapride and Cimetidine in Severe Reflux Oesophagitis: a Double Blind Controlled Trial." Gut, vol. 29, no. 5, 1988, pp. 675-81.
Galmiche JP, Brandstätter G, Evreux M, et al. Combined therapy with cisapride and cimetidine in severe reflux oesophagitis: a double blind controlled trial. Gut. 1988;29(5):675-81.
Galmiche, J. P., Brandstätter, G., Evreux, M., Hentschel, E., Kerstan, E., Kratochvil, P., Reichel, W., Schütze, K., Soule, J. C., & Vitaux, J. (1988). Combined therapy with cisapride and cimetidine in severe reflux oesophagitis: a double blind controlled trial. Gut, 29(5), 675-81.
Galmiche JP, et al. Combined Therapy With Cisapride and Cimetidine in Severe Reflux Oesophagitis: a Double Blind Controlled Trial. Gut. 1988;29(5):675-81. PubMed PMID: 3294124.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Combined therapy with cisapride and cimetidine in severe reflux oesophagitis: a double blind controlled trial. AU - Galmiche,J P, AU - Brandstätter,G, AU - Evreux,M, AU - Hentschel,E, AU - Kerstan,E, AU - Kratochvil,P, AU - Reichel,W, AU - Schütze,K, AU - Soule,J C, AU - Vitaux,J, PY - 1988/5/1/pubmed PY - 1988/5/1/medline PY - 1988/5/1/entrez SP - 675 EP - 81 JF - Gut JO - Gut VL - 29 IS - 5 N2 - Combined treatment with cimetidine 1 g daily and cisapride 40 mg daily in patients with endoscopically diagnosed severe reflux oesophagitis was compared with single drug therapy (cimetidine and placebo). At the end of the six to 12 weeks treatment, 11 (46%) of the 24 patients under single drug therapy were endoscopically healed and three were improved. In contrast, 16 (70%) of the 23 patients under combined therapy were healed and all of the remainder were improved (p = 0.025). The severity of diurnal and nocturnal heartburn, decreased significantly more (p less than 0.05) on cimetidine + cisapride than on cimetidine + placebo. The combined treatment was well tolerated. These results suggest that combined therapy with cisapride and cimetidine may be useful in patients with severe reflux oesophagitis. SN - 0017-5749 UR - https://www.unboundmedicine.com/medline/citation/3294124/Combined_therapy_with_cisapride_and_cimetidine_in_severe_reflux_oesophagitis:_a_double_blind_controlled_trial_ L2 - http://gut.bmj.com/cgi/pmidlookup?view=long&pmid=3294124 DB - PRIME DP - Unbound Medicine ER -