Tags

Type your tag names separated by a space and hit enter

The Role of Noncoding RNAs in Gout.
Endocrinology. 2020 11 01; 161(11)E

Abstract

Over the past decade, noncoding ribonucleic acids (ncRNAs) have been shown to have crucial functional importance in health and disease. ncRNAs have been well studied and may be involved in the development of inflammatory arthritis, including gouty arthritis. Gout is also associated with metabolic pathway disorders, such as hyperuricemia, due to disturbed purine nucleotide metabolism or excretion of uric acid through the kidney. Moreover, their presence in the circulation has led to the idea that ncRNAs might serve as biomarkers for specific disease states to guide clinical decision-making. Therefore, we summarize the emerging evidence and review the current literature on the regulatory role of miRNAs and lncRNAs in gout pathophysiology. We further discuss the opportunities and challenges of ncRNAs as new blood-based biomarkers for future studies aimed at translation into clinical applications in the diagnosis and therapy of gout.

Links

Publisher Full Text (DOI)

Authors+Show Affiliations

Li X
Laboratory Medicine Center, Lanzhou University Second Hospital, Lanzhou, China.
Pan Y
Laboratory Medicine Center, Lanzhou University Second Hospital, Lanzhou, China.
Li W
Laboratory Medicine Center, Lanzhou University Second Hospital, Lanzhou, China.
Guan P
Laboratory Medicine Center, Lanzhou University Second Hospital, Lanzhou, China.
You C
Laboratory Medicine Center, Lanzhou University Second Hospital, Lanzhou, China.

MeSH

BiomarkersGoutHumansHyperuricemiaMetabolic Networks and PathwaysMicroRNAsRNA, Long Noncoding

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

32941616

Citation

Li, Xue, et al. "The Role of Noncoding RNAs in Gout." Endocrinology, vol. 161, no. 11, 2020.
Li X, Pan Y, Li W, et al. The Role of Noncoding RNAs in Gout. Endocrinology. 2020;161(11).
Li, X., Pan, Y., Li, W., Guan, P., & You, C. (2020). The Role of Noncoding RNAs in Gout. Endocrinology, 161(11). https://doi.org/10.1210/endocr/bqaa165
Li X, et al. The Role of Noncoding RNAs in Gout. Endocrinology. 2020 11 1;161(11) PubMed PMID: 32941616.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The Role of Noncoding RNAs in Gout. AU - Li,Xue, AU - Pan,Yunyan, AU - Li,Wei, AU - Guan,Peiwen, AU - You,Chongge, PY - 2020/06/10/received PY - 2020/09/15/accepted PY - 2020/9/18/pubmed PY - 2021/1/30/medline PY - 2020/9/17/entrez KW - Gout KW - LncRNA KW - MicroRNAs KW - non-coding RNA JF - Endocrinology JO - Endocrinology VL - 161 IS - 11 N2 - Over the past decade, noncoding ribonucleic acids (ncRNAs) have been shown to have crucial functional importance in health and disease. ncRNAs have been well studied and may be involved in the development of inflammatory arthritis, including gouty arthritis. Gout is also associated with metabolic pathway disorders, such as hyperuricemia, due to disturbed purine nucleotide metabolism or excretion of uric acid through the kidney. Moreover, their presence in the circulation has led to the idea that ncRNAs might serve as biomarkers for specific disease states to guide clinical decision-making. Therefore, we summarize the emerging evidence and review the current literature on the regulatory role of miRNAs and lncRNAs in gout pathophysiology. We further discuss the opportunities and challenges of ncRNAs as new blood-based biomarkers for future studies aimed at translation into clinical applications in the diagnosis and therapy of gout. SN - 1945-7170 UR - https://www.unboundmedicine.com/medline/citation/32941616/The_Role_of_Noncoding_RNAs_in_Gout_ DB - PRIME DP - Unbound Medicine ER -