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The Relation of the Brain-Derived Neurotrophic Factor with MicroRNAs in Neurodegenerative Diseases and Ischemic Stroke.
Mol Neurobiol. 2021 Jan; 58(1):329-347.MN

Abstract

Brain-derived neurotrophic factor (BDNF) is a member of the neurotrophin family of growth factors that plays a crucial role in the development of the nervous system while supporting the survival of existing neurons and instigating neurogenesis. Altered levels of BDNF, both in the circulation and in the central nervous system (CNS), have been reported to be involved in the pathogenesis of neurodegenerative diseases, including Alzheimer's disease (AD), Parkinson's disease (PD), amyotrophic lateral sclerosis (ALS), Huntington's disease (HD), multiple sclerosis (MS), and ischemic stroke. MicroRNAs (miRNAs) are a class of non-coding RNAs found in body fluids such as peripheral blood and cerebrospinal fluid. Several different miRNAs, and their target genes, are recognized to be involved in the pathophysiology of neurodegenerative and neurovascular diseases. Thus, they present as promising biomarkers and a novel treatment approach for CNS disorders. Currently, limited studies provide viable evidence of miRNA-mediated post-transcriptional regulation of BDNF. The aim of this review is to provide a comprehensive assessment of the current knowledge regarding the potential diagnostic and prognostic values of miRNAs affecting BDNF expression and its role as a CNS disorders and neurovascular disease biomarker. Moreover, a novel therapeutic approach in neurodegenerative diseases and ischemic stroke targeting miRNAs associated with BDNF will be discussed.

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Authors+Show Affiliations

Department of Experimental and Clinical Pharmacology, Medical University of Warsaw, Center for Preclinical Research and Technology CEPT, Banacha 1B Str., 02-097, Warsaw, Poland.

Department of Experimental and Clinical Pharmacology, Medical University of Warsaw, Center for Preclinical Research and Technology CEPT, Banacha 1B Str., 02-097, Warsaw, Poland.

Department of Experimental and Clinical Pharmacology, Medical University of Warsaw, Center for Preclinical Research and Technology CEPT, Banacha 1B Str., 02-097, Warsaw, Poland. Centro de Matemática, Computação e Cognição, Universidade Federal do ABC, São Paulo, Brazil.

Department of Experimental and Clinical Pharmacology, Medical University of Warsaw, Center for Preclinical Research and Technology CEPT, Banacha 1B Str., 02-097, Warsaw, Poland.

Department of Experimental and Clinical Pharmacology, Medical University of Warsaw, Center for Preclinical Research and Technology CEPT, Banacha 1B Str., 02-097, Warsaw, Poland.

Department of Experimental and Clinical Pharmacology, Medical University of Warsaw, Center for Preclinical Research and Technology CEPT, Banacha 1B Str., 02-097, Warsaw, Poland.

Department of Experimental and Clinical Pharmacology, Medical University of Warsaw, Center for Preclinical Research and Technology CEPT, Banacha 1B Str., 02-097, Warsaw, Poland.

2nd Department of Neurology, Institute of Psychiatry and Neurology, 02-957, Warsaw, Poland.

Kaplon-Cieslicka A

1st Chair and Department of Cardiology, Medical University of Warsaw, Warsaw, Poland.

Mirowska-Guzel D

Department of Experimental and Clinical Pharmacology, Medical University of Warsaw, Center for Preclinical Research and Technology CEPT, Banacha 1B Str., 02-097, Warsaw, Poland. dmirowska@wum.edu.pl.

MeSH

AnimalsBrain-Derived Neurotrophic FactorHumansIschemic StrokeMicroRNAsModels, BiologicalMolecular Targeted TherapyNeurodegenerative Diseases

Pub Type(s)

Journal Article

Review

Language

eng

PubMed ID

32944919

Citation

Eyileten, Ceren, et al. "The Relation of the Brain-Derived Neurotrophic Factor With MicroRNAs in Neurodegenerative Diseases and Ischemic Stroke." Molecular Neurobiology, vol. 58, no. 1, 2021, pp. 329-347.

Eyileten C, Sharif L, Wicik Z, et al. The Relation of the Brain-Derived Neurotrophic Factor with MicroRNAs in Neurodegenerative Diseases and Ischemic Stroke. Mol Neurobiol. 2021;58(1):329-347.

Eyileten, C., Sharif, L., Wicik, Z., Jakubik, D., Jarosz-Popek, J., Soplinska, A., Postula, M., Czlonkowska, A., Kaplon-Cieslicka, A., & Mirowska-Guzel, D. (2021). The Relation of the Brain-Derived Neurotrophic Factor with MicroRNAs in Neurodegenerative Diseases and Ischemic Stroke. Molecular Neurobiology, 58(1), 329-347. https://doi.org/10.1007/s12035-020-02101-2

Eyileten C, et al. The Relation of the Brain-Derived Neurotrophic Factor With MicroRNAs in Neurodegenerative Diseases and Ischemic Stroke. Mol Neurobiol. 2021;58(1):329-347. PubMed PMID: 32944919.

* Article titles in AMA citation format should be in sentence-case

TY - JOUR T1 - The Relation of the Brain-Derived Neurotrophic Factor with MicroRNAs in Neurodegenerative Diseases and Ischemic Stroke. AU - Eyileten,Ceren, AU - Sharif,Lucia, AU - Wicik,Zofia, AU - Jakubik,Daniel, AU - Jarosz-Popek,Joanna, AU - Soplinska,Aleksandra, AU - Postula,Marek, AU - Czlonkowska,Anna, AU - Kaplon-Cieslicka,Agnieszka, AU - Mirowska-Guzel,Dagmara, Y1 - 2020/09/17/ PY - 2020/05/19/received PY - 2020/08/25/accepted PY - 2020/9/19/pubmed PY - 2021/8/5/medline PY - 2020/9/18/entrez KW - BDNF KW - Neurodegenerative disease KW - Neurotrophic factor KW - Neurotrophin KW - Neurovascular disease KW - Novel treatment KW - Peripheral biomarker KW - Stroke KW - miRNA SP - 329 EP - 347 JF - Molecular neurobiology JO - Mol Neurobiol VL - 58 IS - 1 N2 - Brain-derived neurotrophic factor (BDNF) is a member of the neurotrophin family of growth factors that plays a crucial role in the development of the nervous system while supporting the survival of existing neurons and instigating neurogenesis. Altered levels of BDNF, both in the circulation and in the central nervous system (CNS), have been reported to be involved in the pathogenesis of neurodegenerative diseases, including Alzheimer's disease (AD), Parkinson's disease (PD), amyotrophic lateral sclerosis (ALS), Huntington's disease (HD), multiple sclerosis (MS), and ischemic stroke. MicroRNAs (miRNAs) are a class of non-coding RNAs found in body fluids such as peripheral blood and cerebrospinal fluid. Several different miRNAs, and their target genes, are recognized to be involved in the pathophysiology of neurodegenerative and neurovascular diseases. Thus, they present as promising biomarkers and a novel treatment approach for CNS disorders. Currently, limited studies provide viable evidence of miRNA-mediated post-transcriptional regulation of BDNF. The aim of this review is to provide a comprehensive assessment of the current knowledge regarding the potential diagnostic and prognostic values of miRNAs affecting BDNF expression and its role as a CNS disorders and neurovascular disease biomarker. Moreover, a novel therapeutic approach in neurodegenerative diseases and ischemic stroke targeting miRNAs associated with BDNF will be discussed. SN - 1559-1182 UR - https://www.unboundmedicine.com/medline/citation/32944919/The_Relation_of_the_Brain_Derived_Neurotrophic_Factor_with_MicroRNAs_in_Neurodegenerative_Diseases_and_Ischemic_Stroke_ DB - PRIME DP - Unbound Medicine ER -