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Exploring links between vitamin D deficiency and COVID-19.
PLoS Pathog. 2020 09; 16(9):e1008874.PP

Abstract

Coronavirus Disease 2019 (COVID-19) pandemic remains a major public health threat in most countries. The causative severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus can lead to acute respiratory distress syndrome and result in mortality in COVID-19 patients. Vitamin D is an immunomodulator hormone with established effectiveness against various upper respiratory infections. Vitamin D can stall hyper-inflammatory responses and expedite healing process of the affected areas, primarily in the lung tissue. Thus, there are ecological and mechanistic reasons to promote exploration of vitamin D action in COVID-19 patients. As no curative drugs are available currently for COVID-19, we feel that the potential of vitamin D to alter the course of disease severity needs to be investigated. Clinical studies may be undertaken to address the value of vitamin D supplementation in deficient, high-risk COVID-19 patients.

Authors+Show Affiliations

Parasite-Host Biology Group, National Institute of Malaria Research, New Delhi, India.Division of Basic Medical Sciences, Indian Council of Medical Research, New Delhi, India.Parasite-Host Biology Group, National Institute of Malaria Research, New Delhi, India. Structural Parasitology Group, International Centre for Genetic Engineering and Biotechnology, New Delhi, India.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

32946517

Citation

Mohan, Mradul, et al. "Exploring Links Between Vitamin D Deficiency and COVID-19." PLoS Pathogens, vol. 16, no. 9, 2020, pp. e1008874.
Mohan M, Cherian JJ, Sharma A. Exploring links between vitamin D deficiency and COVID-19. PLoS Pathog. 2020;16(9):e1008874.
Mohan, M., Cherian, J. J., & Sharma, A. (2020). Exploring links between vitamin D deficiency and COVID-19. PLoS Pathogens, 16(9), e1008874. https://doi.org/10.1371/journal.ppat.1008874
Mohan M, Cherian JJ, Sharma A. Exploring Links Between Vitamin D Deficiency and COVID-19. PLoS Pathog. 2020;16(9):e1008874. PubMed PMID: 32946517.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Exploring links between vitamin D deficiency and COVID-19. AU - Mohan,Mradul, AU - Cherian,Jerin Jose, AU - Sharma,Amit, Y1 - 2020/09/18/ PY - 2020/9/18/entrez PY - 2020/9/19/pubmed PY - 2020/10/2/medline SP - e1008874 EP - e1008874 JF - PLoS pathogens JO - PLoS Pathog VL - 16 IS - 9 N2 - Coronavirus Disease 2019 (COVID-19) pandemic remains a major public health threat in most countries. The causative severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus can lead to acute respiratory distress syndrome and result in mortality in COVID-19 patients. Vitamin D is an immunomodulator hormone with established effectiveness against various upper respiratory infections. Vitamin D can stall hyper-inflammatory responses and expedite healing process of the affected areas, primarily in the lung tissue. Thus, there are ecological and mechanistic reasons to promote exploration of vitamin D action in COVID-19 patients. As no curative drugs are available currently for COVID-19, we feel that the potential of vitamin D to alter the course of disease severity needs to be investigated. Clinical studies may be undertaken to address the value of vitamin D supplementation in deficient, high-risk COVID-19 patients. SN - 1553-7374 UR - https://www.unboundmedicine.com/medline/citation/32946517/Exploring_links_between_vitamin_D_deficiency_and_COVID_19_ L2 - https://dx.plos.org/10.1371/journal.ppat.1008874 DB - PRIME DP - Unbound Medicine ER -