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The Effects of Common Over-the-Counter Moisturizers on Skin Barrier Function: A Randomized, Observer-Blind, Within-Patient, Controlled Study.
Dermatitis. 2020 Sep/Oct; 31(5):309-315.D

Abstract

BACKGROUND

Moisturizers possibly improve atopic dermatitis (AD) by restoration of skin barrier, although some have detrimental effects.

OBJECTIVE

The aim of the study was to estimate the effects of several routine moisturizers on barrier functions.

METHODS

This is a randomized, forearm-controlled, observer-blind study. Patients older than 12 years with clear to moderate AD were randomized to 1 of 4 moisturizers (Cetaphil Cream, Aveeno Eczema Therapy Moisturizing Cream, CeraVe Moisturizing Cream, Vaseline) applied to nonlesional skin of 1 forearm and no moisturizer to the opposite forearm for 4 weeks. Transepidermal water loss (TEWL), capacitance, pH, and TEWL after tape stripping were evaluated at weeks 0 and 4. In addition, participants without AD underwent baseline measurements only.

RESULTS

Twenty patients with AD completed the study. Baseline measurements between the AD group and 10 non-AD controls were similar. After the intervention (AD group), mean TEWL improved in the treated forearm and worsened in the untreated one, but the difference was not significant. There was no significant change in pH or in TEWL after tape stripping. Capacitance significantly improved in the moisturizer forearm. The study was underpowered as recruitment fell short.

CONCLUSIONS

The effects of moisturizers on nonlesional AD skin were small and need to be addressed when powering future studies. Broadening investigations beyond the classic barrier properties might be useful in future studies.

Authors+Show Affiliations

From the Division of Dermatology, Beilinson Hospital, Petach Tikva, Israel. Sackler Faculty of Medicine, Tel Aviv University, Israel.Department of Dermatology, Oregon Health and Science University, Portland, Oregon.Department of Dermatology, Oregon Health and Science University, Portland, Oregon.Department of Dermatology, Oregon Health and Science University, Portland, Oregon.

Pub Type(s)

Controlled Clinical Trial
Journal Article
Observational Study
Randomized Controlled Trial

Language

eng

PubMed ID

32947459

Citation

Leshem, Yael Anne, et al. "The Effects of Common Over-the-Counter Moisturizers On Skin Barrier Function: a Randomized, Observer-Blind, Within-Patient, Controlled Study." Dermatitis : Contact, Atopic, Occupational, Drug, vol. 31, no. 5, 2020, pp. 309-315.
Leshem YA, Wong A, McClanahan D, et al. The Effects of Common Over-the-Counter Moisturizers on Skin Barrier Function: A Randomized, Observer-Blind, Within-Patient, Controlled Study. Dermatitis. 2020;31(5):309-315.
Leshem, Y. A., Wong, A., McClanahan, D., & Simpson, E. L. (2020). The Effects of Common Over-the-Counter Moisturizers on Skin Barrier Function: A Randomized, Observer-Blind, Within-Patient, Controlled Study. Dermatitis : Contact, Atopic, Occupational, Drug, 31(5), 309-315. https://doi.org/10.1097/DER.0000000000000623
Leshem YA, et al. The Effects of Common Over-the-Counter Moisturizers On Skin Barrier Function: a Randomized, Observer-Blind, Within-Patient, Controlled Study. Dermatitis. 2020 Sep/Oct;31(5):309-315. PubMed PMID: 32947459.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The Effects of Common Over-the-Counter Moisturizers on Skin Barrier Function: A Randomized, Observer-Blind, Within-Patient, Controlled Study. AU - Leshem,Yael Anne, AU - Wong,Allison, AU - McClanahan,Danielle, AU - Simpson,Eric L, PY - 2020/9/18/entrez PY - 2020/9/19/pubmed PY - 2021/7/23/medline SP - 309 EP - 315 JF - Dermatitis : contact, atopic, occupational, drug JO - Dermatitis VL - 31 IS - 5 N2 - BACKGROUND: Moisturizers possibly improve atopic dermatitis (AD) by restoration of skin barrier, although some have detrimental effects. OBJECTIVE: The aim of the study was to estimate the effects of several routine moisturizers on barrier functions. METHODS: This is a randomized, forearm-controlled, observer-blind study. Patients older than 12 years with clear to moderate AD were randomized to 1 of 4 moisturizers (Cetaphil Cream, Aveeno Eczema Therapy Moisturizing Cream, CeraVe Moisturizing Cream, Vaseline) applied to nonlesional skin of 1 forearm and no moisturizer to the opposite forearm for 4 weeks. Transepidermal water loss (TEWL), capacitance, pH, and TEWL after tape stripping were evaluated at weeks 0 and 4. In addition, participants without AD underwent baseline measurements only. RESULTS: Twenty patients with AD completed the study. Baseline measurements between the AD group and 10 non-AD controls were similar. After the intervention (AD group), mean TEWL improved in the treated forearm and worsened in the untreated one, but the difference was not significant. There was no significant change in pH or in TEWL after tape stripping. Capacitance significantly improved in the moisturizer forearm. The study was underpowered as recruitment fell short. CONCLUSIONS: The effects of moisturizers on nonlesional AD skin were small and need to be addressed when powering future studies. Broadening investigations beyond the classic barrier properties might be useful in future studies. SN - 2162-5220 UR - https://www.unboundmedicine.com/medline/citation/32947459/The_Effects_of_Common_Over_the_Counter_Moisturizers_on_Skin_Barrier_Function:_A_Randomized_Observer_Blind_Within_Patient_Controlled_Study_ DB - PRIME DP - Unbound Medicine ER -