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Outbreak of Enterovirus D68 Among Children in Japan-Worldwide Circulation of Enterovirus D68 Clade B3 in 2018.
Pediatr Infect Dis J. 2021 01; 40(1):6-10.PI

Abstract

BACKGROUND

Enterovirus D68 (EV-D68) causes asthma-like respiratory infection in children. Several EV-D68 outbreaks have been reported worldwide since the largest outbreak occurred in the United States in 2014. We experienced an accumulation of pediatric cases with asthma-like respiratory illness in Niigata, Japan, in 2018.

STUDY DESIGN

To determine whether EV-D68 was responsible for the case accumulation, this prospective observational study evaluated children hospitalized in 1 of 8 hospitals with asthma-like respiratory illness in Niigata, Japan, during October and November 2018. Diagnoses were made by EV-D68-specific RT-PCR using nasopharyngeal samples. The clade was identified by sequence analyses, and a phylogenetic tree was created. To evaluate seasonal variation, data from pediatric cases with asthma-like respiratory illness in 2018 were retrospectively analyzed.

RESULTS

In 2018, 114 children were hospitalized with asthma-like respiratory illness in October and November, and 47 nasopharyngeal samples were collected. EV-D68 was detected in 22/47 (47%) patients during the study period. The phylogenetic tree revealed that all strains belonged to the clade B3 branch, which has been detected worldwide every 2 years since 2014.

CONCLUSIONS

EV-D68 was the associated pathogen for asthma-like respiratory illness in children in Japan in 2018. Clade B3, the dominant clade in outbreaks worldwide, was responsible for the outbreak. Detection and detailed virologic analysis of EV-D68 is important as part of worldwide surveillance, as it will aid in understanding the epidemiologic characteristics of EV-D68 infection.

Authors+Show Affiliations

From the Department of Pediatrics, Niigata University Graduate School of Medical and Dental Sciences.From the Department of Pediatrics, Niigata University Graduate School of Medical and Dental Sciences.Department of Pediatrics, Niigata City General Hospital.From the Department of Pediatrics, Niigata University Graduate School of Medical and Dental Sciences.Department of Medical Technology, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan.From the Department of Pediatrics, Niigata University Graduate School of Medical and Dental Sciences.From the Department of Pediatrics, Niigata University Graduate School of Medical and Dental Sciences.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

32947598

Citation

Ikuse, Tatsuki, et al. "Outbreak of Enterovirus D68 Among Children in Japan-Worldwide Circulation of Enterovirus D68 Clade B3 in 2018." The Pediatric Infectious Disease Journal, vol. 40, no. 1, 2021, pp. 6-10.
Ikuse T, Aizawa Y, Yamanaka T, et al. Outbreak of Enterovirus D68 Among Children in Japan-Worldwide Circulation of Enterovirus D68 Clade B3 in 2018. Pediatr Infect Dis J. 2021;40(1):6-10.
Ikuse, T., Aizawa, Y., Yamanaka, T., Habuka, R., Watanabe, K., Otsuka, T., & Saitoh, A. (2021). Outbreak of Enterovirus D68 Among Children in Japan-Worldwide Circulation of Enterovirus D68 Clade B3 in 2018. The Pediatric Infectious Disease Journal, 40(1), 6-10. https://doi.org/10.1097/INF.0000000000002889
Ikuse T, et al. Outbreak of Enterovirus D68 Among Children in Japan-Worldwide Circulation of Enterovirus D68 Clade B3 in 2018. Pediatr Infect Dis J. 2021;40(1):6-10. PubMed PMID: 32947598.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Outbreak of Enterovirus D68 Among Children in Japan-Worldwide Circulation of Enterovirus D68 Clade B3 in 2018. AU - Ikuse,Tatsuki, AU - Aizawa,Yuta, AU - Yamanaka,Takayuki, AU - Habuka,Rie, AU - Watanabe,Kanako, AU - Otsuka,Taketo, AU - Saitoh,Akihiko, PY - 2020/9/19/pubmed PY - 2021/8/26/medline PY - 2020/9/18/entrez SP - 6 EP - 10 JF - The Pediatric infectious disease journal JO - Pediatr Infect Dis J VL - 40 IS - 1 N2 - BACKGROUND: Enterovirus D68 (EV-D68) causes asthma-like respiratory infection in children. Several EV-D68 outbreaks have been reported worldwide since the largest outbreak occurred in the United States in 2014. We experienced an accumulation of pediatric cases with asthma-like respiratory illness in Niigata, Japan, in 2018. STUDY DESIGN: To determine whether EV-D68 was responsible for the case accumulation, this prospective observational study evaluated children hospitalized in 1 of 8 hospitals with asthma-like respiratory illness in Niigata, Japan, during October and November 2018. Diagnoses were made by EV-D68-specific RT-PCR using nasopharyngeal samples. The clade was identified by sequence analyses, and a phylogenetic tree was created. To evaluate seasonal variation, data from pediatric cases with asthma-like respiratory illness in 2018 were retrospectively analyzed. RESULTS: In 2018, 114 children were hospitalized with asthma-like respiratory illness in October and November, and 47 nasopharyngeal samples were collected. EV-D68 was detected in 22/47 (47%) patients during the study period. The phylogenetic tree revealed that all strains belonged to the clade B3 branch, which has been detected worldwide every 2 years since 2014. CONCLUSIONS: EV-D68 was the associated pathogen for asthma-like respiratory illness in children in Japan in 2018. Clade B3, the dominant clade in outbreaks worldwide, was responsible for the outbreak. Detection and detailed virologic analysis of EV-D68 is important as part of worldwide surveillance, as it will aid in understanding the epidemiologic characteristics of EV-D68 infection. SN - 1532-0987 UR - https://www.unboundmedicine.com/medline/citation/32947598/Outbreak_of_Enterovirus_D68_Among_Children_in_Japan_Worldwide_Circulation_of_Enterovirus_D68_Clade_B3_in_2018_ L2 - https://doi.org/10.1097/INF.0000000000002889 DB - PRIME DP - Unbound Medicine ER -