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Cardiovascular Complications Associated with COVID-19 and Potential Therapeutic~Strategies.
Int J Mol Sci. 2020 Sep 16; 21(18)IJ

Abstract

The outbreak of coronavirus disease 2019 (COVID-19), an infectious disease with severe acute respiratory syndrome, has now become a worldwide pandemic. Despite the respiratory complication, COVID-19 is also associated with significant multiple organ dysfunction, including severe cardiac impairment. Emerging evidence reveals a direct interplay between COVID-19 and dire cardiovascular complications, including myocardial injury, heart failure, heart attack, myocarditis, arrhythmias as well as blood clots, which are accompanied with elevated risk and adverse outcome among infected patients, even sudden death. The proposed pathophysiological mechanisms of myocardial impairment include invasion of SARS-CoV-2 virus via angiotensin-converting enzyme 2 to cardiovascular cells/tissue, which leads to endothelial inflammation and dysfunction, de-stabilization of vulnerable atherosclerotic plaques, stent thrombosis, cardiac stress due to diminish oxygen supply and cardiac muscle damage, and myocardial infarction. Several promising therapeutics are under investigation to the overall prognosis of COVID-19 patients with high risk of cardiovascular impairment, nevertheless to date, none have shown proven clinical efficacy. In this comprehensive review, we aimed to highlight the current integrated therapeutic approaches for COVID-19 and we summarized the potential therapeutic options, currently under clinical trials, with their mechanisms of action and associated adverse cardiac events in highly infectious COVID-19 patients.

Authors+Show Affiliations

Division of Cardiology, Pauley Heart Center, Internal Medicine, Virginia Commonwealth University, Richmond, VA 23298, USA.Division of Cardiology, Pauley Heart Center, Internal Medicine, Virginia Commonwealth University, Richmond, VA 23298, USA.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

32947927

Citation

Samidurai, Arun, and Anindita Das. "Cardiovascular Complications Associated With COVID-19 and Potential Therapeutic~Strategies." International Journal of Molecular Sciences, vol. 21, no. 18, 2020.
Samidurai A, Das A. Cardiovascular Complications Associated with COVID-19 and Potential Therapeutic~Strategies. Int J Mol Sci. 2020;21(18).
Samidurai, A., & Das, A. (2020). Cardiovascular Complications Associated with COVID-19 and Potential Therapeutic~Strategies. International Journal of Molecular Sciences, 21(18). https://doi.org/10.3390/ijms21186790
Samidurai A, Das A. Cardiovascular Complications Associated With COVID-19 and Potential Therapeutic~Strategies. Int J Mol Sci. 2020 Sep 16;21(18) PubMed PMID: 32947927.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Cardiovascular Complications Associated with COVID-19 and Potential Therapeutic~Strategies. AU - Samidurai,Arun, AU - Das,Anindita, Y1 - 2020/09/16/ PY - 2020/08/01/received PY - 2020/09/10/revised PY - 2020/09/11/accepted PY - 2020/9/19/entrez PY - 2020/9/20/pubmed PY - 2020/9/24/medline KW - COVID-19 KW - cardiovascular diseases KW - treatment strategies JF - International journal of molecular sciences JO - Int J Mol Sci VL - 21 IS - 18 N2 - The outbreak of coronavirus disease 2019 (COVID-19), an infectious disease with severe acute respiratory syndrome, has now become a worldwide pandemic. Despite the respiratory complication, COVID-19 is also associated with significant multiple organ dysfunction, including severe cardiac impairment. Emerging evidence reveals a direct interplay between COVID-19 and dire cardiovascular complications, including myocardial injury, heart failure, heart attack, myocarditis, arrhythmias as well as blood clots, which are accompanied with elevated risk and adverse outcome among infected patients, even sudden death. The proposed pathophysiological mechanisms of myocardial impairment include invasion of SARS-CoV-2 virus via angiotensin-converting enzyme 2 to cardiovascular cells/tissue, which leads to endothelial inflammation and dysfunction, de-stabilization of vulnerable atherosclerotic plaques, stent thrombosis, cardiac stress due to diminish oxygen supply and cardiac muscle damage, and myocardial infarction. Several promising therapeutics are under investigation to the overall prognosis of COVID-19 patients with high risk of cardiovascular impairment, nevertheless to date, none have shown proven clinical efficacy. In this comprehensive review, we aimed to highlight the current integrated therapeutic approaches for COVID-19 and we summarized the potential therapeutic options, currently under clinical trials, with their mechanisms of action and associated adverse cardiac events in highly infectious COVID-19 patients. SN - 1422-0067 UR - https://www.unboundmedicine.com/medline/citation/32947927/Cardiovascular_Complications_Associated_with_COVID_19_and_Potential_Therapeutic~Strategies_ L2 - https://www.mdpi.com/resolver?pii=ijms21186790 DB - PRIME DP - Unbound Medicine ER -