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Comparisons of cardiovascular dysautonomia and cognitive impairment between de novo Parkinson's disease and de novo dementia with Lewy bodies.
BMC Neurol. 2020 Sep 18; 20(1):350.BN

Abstract

BACKGROUND

Cognitive impairment may be correlated with cardiovascular dysautonomia, including blood pressure (BP) dysregulation, in Parkinson's disease (PD), but the association between these factors in dementia with Lewy bodies (DLB) is uncertain. This study aimed to clarify whether cardiovascular dysautonomia had an influence on cognitive function in Lewy body disease or not.

METHODS

Ninty-nine patients with de novo PD (n = 75) and DLB (n = 24) were evaluated using the Mini-Mental State Examination (MMSE) and Frontal Assessment Battery (FAB). Cardiac 123I-metaiodobenzylguanidine (MIBG) scintigraphy, orthostatic hypotension (OH), supine hypertension (SH), postprandial hypotension (PPH), nocturnal BP fall in 24-h ambulatory blood pressure monitoring (ABPM) and constipation were estimated. Associations of these factors with cognitive and executive dysfunction were examined.

RESULTS

In DLB, MIBG uptake was reduced and OH, PPH and SH were severely disturbed, compared to PD. The nocturnal BP fall in ABPM was lower in DLB, and the failure of nocturnal BP fall in PD was associated with MMSE, after adjustment for other clinical features. FAB was significantly associated nocturnal BP fall, age and SH in PD, but no significant correlations among factors were found for DLB.

CONCLUSION

The significant association between nocturnal BP dysregulation and cognitive or executive decline in PD might be due to impaired microvascular circulation or invasion of α-synuclein in the CNS. The lack of a correlation of BP insufficiency with cognitive impairment in DLB suggests initial involvement of Lewy body pathology in the neocortex, regardless of Lewy body invasion of the autonomic nervous system.

Authors+Show Affiliations

Department of Neurology, Daisan Hospital, The Jikei University School of Medicine, 4-11-1 Izumihoncho, Komae-shi, Tokyo, 201-8601, Japan. h.oka@jikei.ac.jp.Department of Neurology, The Jikei University School of Medicine, 3-19-18, Tokyo, 105-8471, Japan. tumety@jikei.ac.jp.Department of Neurology, Daisan Hospital, The Jikei University School of Medicine, 4-11-1 Izumihoncho, Komae-shi, Tokyo, 201-8601, Japan.Department of Neurology, The Jikei University School of Medicine, 3-19-18, Tokyo, 105-8471, Japan.

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

32948137

Citation

Oka, Hisayoshi, et al. "Comparisons of Cardiovascular Dysautonomia and Cognitive Impairment Between De Novo Parkinson's Disease and De Novo Dementia With Lewy Bodies." BMC Neurology, vol. 20, no. 1, 2020, p. 350.
Oka H, Umehara T, Nakahara A, et al. Comparisons of cardiovascular dysautonomia and cognitive impairment between de novo Parkinson's disease and de novo dementia with Lewy bodies. BMC Neurol. 2020;20(1):350.
Oka, H., Umehara, T., Nakahara, A., & Matsuno, H. (2020). Comparisons of cardiovascular dysautonomia and cognitive impairment between de novo Parkinson's disease and de novo dementia with Lewy bodies. BMC Neurology, 20(1), 350. https://doi.org/10.1186/s12883-020-01928-5
Oka H, et al. Comparisons of Cardiovascular Dysautonomia and Cognitive Impairment Between De Novo Parkinson's Disease and De Novo Dementia With Lewy Bodies. BMC Neurol. 2020 Sep 18;20(1):350. PubMed PMID: 32948137.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Comparisons of cardiovascular dysautonomia and cognitive impairment between de novo Parkinson's disease and de novo dementia with Lewy bodies. AU - Oka,Hisayoshi, AU - Umehara,Tadashi, AU - Nakahara,Atsuo, AU - Matsuno,Hiromasa, Y1 - 2020/09/18/ PY - 2019/10/06/received PY - 2020/09/10/accepted PY - 2020/9/19/entrez PY - 2020/9/20/pubmed PY - 2020/11/24/medline KW - Cognitive decline KW - Daily blood pressure fluctuation KW - Dementia with Lewy bodies KW - Orthostatic hypotension KW - Parkinson’s disease SP - 350 EP - 350 JF - BMC neurology JO - BMC Neurol VL - 20 IS - 1 N2 - BACKGROUND: Cognitive impairment may be correlated with cardiovascular dysautonomia, including blood pressure (BP) dysregulation, in Parkinson's disease (PD), but the association between these factors in dementia with Lewy bodies (DLB) is uncertain. This study aimed to clarify whether cardiovascular dysautonomia had an influence on cognitive function in Lewy body disease or not. METHODS: Ninty-nine patients with de novo PD (n = 75) and DLB (n = 24) were evaluated using the Mini-Mental State Examination (MMSE) and Frontal Assessment Battery (FAB). Cardiac 123I-metaiodobenzylguanidine (MIBG) scintigraphy, orthostatic hypotension (OH), supine hypertension (SH), postprandial hypotension (PPH), nocturnal BP fall in 24-h ambulatory blood pressure monitoring (ABPM) and constipation were estimated. Associations of these factors with cognitive and executive dysfunction were examined. RESULTS: In DLB, MIBG uptake was reduced and OH, PPH and SH were severely disturbed, compared to PD. The nocturnal BP fall in ABPM was lower in DLB, and the failure of nocturnal BP fall in PD was associated with MMSE, after adjustment for other clinical features. FAB was significantly associated nocturnal BP fall, age and SH in PD, but no significant correlations among factors were found for DLB. CONCLUSION: The significant association between nocturnal BP dysregulation and cognitive or executive decline in PD might be due to impaired microvascular circulation or invasion of α-synuclein in the CNS. The lack of a correlation of BP insufficiency with cognitive impairment in DLB suggests initial involvement of Lewy body pathology in the neocortex, regardless of Lewy body invasion of the autonomic nervous system. SN - 1471-2377 UR - https://www.unboundmedicine.com/medline/citation/32948137/Comparisons_of_cardiovascular_dysautonomia_and_cognitive_impairment_between_de_novo_Parkinson's_disease_and_de_novo_dementia_with_Lewy_bodies_ L2 - https://bmcneurol.biomedcentral.com/articles/10.1186/s12883-020-01928-5 DB - PRIME DP - Unbound Medicine ER -