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Effects of perioperative magnesium sulfate with controlled hypotension on intraoperative bleeding and postoperative ecchymosis and edema in open rhinoplasty.
Am J Otolaryngol. 2020 Nov - Dec; 41(6):102722.AJ

Abstract

PURPOSE

This randomized, double-blind study was planned to evaluate the effect of perioperative magnesium sulfate with controlled hypotension on intraoperative bleeding, postoperative ecchymosis and edema, and side-effects.

MATERIALS AND METHOD

Forty-nine patients undergoing open rhinoplasty were divided into two groups - magnesium sulfate and control. The magnesium sulfate group received 30-50 mg·kg-1 intravenously as a bolus before induction of anesthesia, followed by 10-20 mg·kg-1 h-1 by continuous intravenous infusion during surgery. Anesthesia was induced with propofol 3 mg·kg-1, fentanyl 15 μg·kg-1 and cisatracurium 0.6 mg·kg-1. Mean arterial pressure was maintained at 50 to 60 mmHg under controlled hypotensive anesthesia with magnesium sulfate titration. Hemodynamic variables, operational bleeding, early postoperative side-effects and postoperative first-, third- and seventh-day ecchymosis and edema were compared between the groups. Ecchymosis and edema were evaluated using a graded scale from 0 to 4.

RESULTS

In the magnesium sulfate group, mean arterial pressure decreased during most of the perioperative period. Intraoperative bleeding also decreased. A distinct reduction in ecchymosis and edema was observed in both the upper and lower eyelids on the first, third and seventh days. Patients in the magnesium sulfate group also had a more peaceful postoperative course with less postoperative nausea vomiting, and shivering.

CONCLUSION

Magnesium sulfate with controlled hypotension can lower ecchymosis and edema of the upper and lower eyelids in rhinoplasty surgery by reducing bleeding.

Links

Publisher Full Text (DOI)

Authors+Show Affiliations

Kosucu M
Medical School of Karadeniz Technical University, Department of Anesthesiology, 61080 Trabzon, Turkey. Electronic address: mugekk73@hotmail.com.
Tugcugil E
Medical School of Karadeniz Technical University, Department of Anesthesiology, 61080 Trabzon, Turkey.
Arslan E
Medical School of Karadeniz Technical University, Department of Neurosurgery, 61080 Trabzon, Turkey.
Omur S
Medical School of Karadeniz Technical University, Department of Anesthesiology, 61080 Trabzon, Turkey.
Livaoglu M
Medical School of Karadeniz Technical University, Department of Plastic and Reconstructive Surgery, 61080 Trabzon, Turkey.

MeSH

AdultAnesthesiaBlood Loss, SurgicalDouble-Blind MethodEcchymosisEdemaEyelid DiseasesFemaleHumansHypotension, ControlledInfusions, IntravenousInjections, IntravenousIntraoperative ComplicationsMagnesium SulfateMaleMiddle AgedNosePerioperative CarePostoperative ComplicationsPostoperative Nausea and VomitingRhinoplasty

Pub Type(s)

Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

32950829

Citation

Kosucu, Muge, et al. "Effects of Perioperative Magnesium Sulfate With Controlled Hypotension On Intraoperative Bleeding and Postoperative Ecchymosis and Edema in Open Rhinoplasty." American Journal of Otolaryngology, vol. 41, no. 6, 2020, p. 102722.
Kosucu M, Tugcugil E, Arslan E, et al. Effects of perioperative magnesium sulfate with controlled hypotension on intraoperative bleeding and postoperative ecchymosis and edema in open rhinoplasty. Am J Otolaryngol. 2020;41(6):102722.
Kosucu, M., Tugcugil, E., Arslan, E., Omur, S., & Livaoglu, M. (2020). Effects of perioperative magnesium sulfate with controlled hypotension on intraoperative bleeding and postoperative ecchymosis and edema in open rhinoplasty. American Journal of Otolaryngology, 41(6), 102722. https://doi.org/10.1016/j.amjoto.2020.102722
Kosucu M, et al. Effects of Perioperative Magnesium Sulfate With Controlled Hypotension On Intraoperative Bleeding and Postoperative Ecchymosis and Edema in Open Rhinoplasty. Am J Otolaryngol. 2020 Nov - Dec;41(6):102722. PubMed PMID: 32950829.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects of perioperative magnesium sulfate with controlled hypotension on intraoperative bleeding and postoperative ecchymosis and edema in open rhinoplasty. AU - Kosucu,Muge, AU - Tugcugil,Ersagun, AU - Arslan,Erhan, AU - Omur,Sahin, AU - Livaoglu,Murat, Y1 - 2020/09/14/ PY - 2020/08/08/received PY - 2020/09/07/accepted PY - 2020/9/21/pubmed PY - 2020/12/15/medline PY - 2020/9/20/entrez KW - Controlled hypotension KW - Magnesium sulfate KW - Perioperatif effect KW - Rhinoplasty SP - 102722 EP - 102722 JF - American journal of otolaryngology JO - Am J Otolaryngol VL - 41 IS - 6 N2 - PURPOSE: This randomized, double-blind study was planned to evaluate the effect of perioperative magnesium sulfate with controlled hypotension on intraoperative bleeding, postoperative ecchymosis and edema, and side-effects. MATERIALS AND METHOD: Forty-nine patients undergoing open rhinoplasty were divided into two groups - magnesium sulfate and control. The magnesium sulfate group received 30-50 mg·kg-1 intravenously as a bolus before induction of anesthesia, followed by 10-20 mg·kg-1 h-1 by continuous intravenous infusion during surgery. Anesthesia was induced with propofol 3 mg·kg-1, fentanyl 15 μg·kg-1 and cisatracurium 0.6 mg·kg-1. Mean arterial pressure was maintained at 50 to 60 mmHg under controlled hypotensive anesthesia with magnesium sulfate titration. Hemodynamic variables, operational bleeding, early postoperative side-effects and postoperative first-, third- and seventh-day ecchymosis and edema were compared between the groups. Ecchymosis and edema were evaluated using a graded scale from 0 to 4. RESULTS: In the magnesium sulfate group, mean arterial pressure decreased during most of the perioperative period. Intraoperative bleeding also decreased. A distinct reduction in ecchymosis and edema was observed in both the upper and lower eyelids on the first, third and seventh days. Patients in the magnesium sulfate group also had a more peaceful postoperative course with less postoperative nausea vomiting, and shivering. CONCLUSION: Magnesium sulfate with controlled hypotension can lower ecchymosis and edema of the upper and lower eyelids in rhinoplasty surgery by reducing bleeding. SN - 1532-818X UR - https://www.unboundmedicine.com/medline/citation/32950829/Effects_of_perioperative_magnesium_sulfate_with_controlled_hypotension_on_intraoperative_bleeding_and_postoperative_ecchymosis_and_edema_in_open_rhinoplasty_ DB - PRIME DP - Unbound Medicine ER -