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Effects of continuous intravenous infusion of an ovine placental extract enriched in placental lactogen on plasma hormones, metabolites and metabolite biokinetics in non-pregnant sheep.

Abstract

Continuous intravenous infusions of saline or of a placental extract containing ovine placental lactogen were given to three non-pregnant, non-lactating ewes over periods of 36 h, 1 week apart. During saline infusion no placental lactogen was detected in jugular vein plasma. but infusion of the placental extract raised the placental lactogen concentration from undetectable to 40-50 micrograms/l, similar to concentrations in ewes with one fetus on day 90 of pregnancy. By comparison with the saline control period, infusion of the placental extract consistently increased both plasma concentrations and irreversible loss of nonesterified fatty acids. Plasma concentrations of glucose and urea, but not irreversible loss of these metabolites, were consistently increased. Although the placental extract was not subjected to extensive purification, it was enriched in placental lactogen and contained no detectable contamination with insulin, prolactin or growth hormone. The results are suggestive of a role for placental lactogen in modifying metabolism and acting during pregnancy to provide nutrients for fetal metabolism.

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  • Publisher Full Text
  • Authors

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    Source

    The Journal of endocrinology 113:2 1987 May pg 277-83

    MeSH

    Animals
    Blood Glucose
    Fatty Acids, Nonesterified
    Female
    Growth Hormone
    Insulin
    Kinetics
    Placental Extracts
    Placental Lactogen
    Prolactin
    Sheep
    Urea

    Pub Type(s)

    Journal Article
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    3295103

    Citation

    Thordarson, G, et al. "Effects of Continuous Intravenous Infusion of an Ovine Placental Extract Enriched in Placental Lactogen On Plasma Hormones, Metabolites and Metabolite Biokinetics in Non-pregnant Sheep." The Journal of Endocrinology, vol. 113, no. 2, 1987, pp. 277-83.
    Thordarson G, McDowell GH, Smith SV, et al. Effects of continuous intravenous infusion of an ovine placental extract enriched in placental lactogen on plasma hormones, metabolites and metabolite biokinetics in non-pregnant sheep. J Endocrinol. 1987;113(2):277-83.
    Thordarson, G., McDowell, G. H., Smith, S. V., Iley, S., & Forsyth, I. A. (1987). Effects of continuous intravenous infusion of an ovine placental extract enriched in placental lactogen on plasma hormones, metabolites and metabolite biokinetics in non-pregnant sheep. The Journal of Endocrinology, 113(2), pp. 277-83.
    Thordarson G, et al. Effects of Continuous Intravenous Infusion of an Ovine Placental Extract Enriched in Placental Lactogen On Plasma Hormones, Metabolites and Metabolite Biokinetics in Non-pregnant Sheep. J Endocrinol. 1987;113(2):277-83. PubMed PMID: 3295103.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Effects of continuous intravenous infusion of an ovine placental extract enriched in placental lactogen on plasma hormones, metabolites and metabolite biokinetics in non-pregnant sheep. AU - Thordarson,G, AU - McDowell,G H, AU - Smith,S V, AU - Iley,S, AU - Forsyth,I A, PY - 1987/5/1/pubmed PY - 1987/5/1/medline PY - 1987/5/1/entrez SP - 277 EP - 83 JF - The Journal of endocrinology JO - J. Endocrinol. VL - 113 IS - 2 N2 - Continuous intravenous infusions of saline or of a placental extract containing ovine placental lactogen were given to three non-pregnant, non-lactating ewes over periods of 36 h, 1 week apart. During saline infusion no placental lactogen was detected in jugular vein plasma. but infusion of the placental extract raised the placental lactogen concentration from undetectable to 40-50 micrograms/l, similar to concentrations in ewes with one fetus on day 90 of pregnancy. By comparison with the saline control period, infusion of the placental extract consistently increased both plasma concentrations and irreversible loss of nonesterified fatty acids. Plasma concentrations of glucose and urea, but not irreversible loss of these metabolites, were consistently increased. Although the placental extract was not subjected to extensive purification, it was enriched in placental lactogen and contained no detectable contamination with insulin, prolactin or growth hormone. The results are suggestive of a role for placental lactogen in modifying metabolism and acting during pregnancy to provide nutrients for fetal metabolism. SN - 0022-0795 UR - https://www.unboundmedicine.com/medline/citation/3295103/Effects_of_continuous_intravenous_infusion_of_an_ovine_placental_extract_enriched_in_placental_lactogen_on_plasma_hormones_metabolites_and_metabolite_biokinetics_in_non_pregnant_sheep_ L2 - https://joe.bioscientifica.com/doi/10.1677/joe.0.1130277 DB - PRIME DP - Unbound Medicine ER -