Tags

Type your tag names separated by a space and hit enter

Effects of continuous intravenous infusion of an ovine placental extract enriched in placental lactogen on plasma hormones, metabolites and metabolite biokinetics in non-pregnant sheep.
J Endocrinol 1987; 113(2):277-83JE

Abstract

Continuous intravenous infusions of saline or of a placental extract containing ovine placental lactogen were given to three non-pregnant, non-lactating ewes over periods of 36 h, 1 week apart. During saline infusion no placental lactogen was detected in jugular vein plasma. but infusion of the placental extract raised the placental lactogen concentration from undetectable to 40-50 micrograms/l, similar to concentrations in ewes with one fetus on day 90 of pregnancy. By comparison with the saline control period, infusion of the placental extract consistently increased both plasma concentrations and irreversible loss of nonesterified fatty acids. Plasma concentrations of glucose and urea, but not irreversible loss of these metabolites, were consistently increased. Although the placental extract was not subjected to extensive purification, it was enriched in placental lactogen and contained no detectable contamination with insulin, prolactin or growth hormone. The results are suggestive of a role for placental lactogen in modifying metabolism and acting during pregnancy to provide nutrients for fetal metabolism.

Authors

No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

3295103

Citation

Thordarson, G, et al. "Effects of Continuous Intravenous Infusion of an Ovine Placental Extract Enriched in Placental Lactogen On Plasma Hormones, Metabolites and Metabolite Biokinetics in Non-pregnant Sheep." The Journal of Endocrinology, vol. 113, no. 2, 1987, pp. 277-83.
Thordarson G, McDowell GH, Smith SV, et al. Effects of continuous intravenous infusion of an ovine placental extract enriched in placental lactogen on plasma hormones, metabolites and metabolite biokinetics in non-pregnant sheep. J Endocrinol. 1987;113(2):277-83.
Thordarson, G., McDowell, G. H., Smith, S. V., Iley, S., & Forsyth, I. A. (1987). Effects of continuous intravenous infusion of an ovine placental extract enriched in placental lactogen on plasma hormones, metabolites and metabolite biokinetics in non-pregnant sheep. The Journal of Endocrinology, 113(2), pp. 277-83.
Thordarson G, et al. Effects of Continuous Intravenous Infusion of an Ovine Placental Extract Enriched in Placental Lactogen On Plasma Hormones, Metabolites and Metabolite Biokinetics in Non-pregnant Sheep. J Endocrinol. 1987;113(2):277-83. PubMed PMID: 3295103.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects of continuous intravenous infusion of an ovine placental extract enriched in placental lactogen on plasma hormones, metabolites and metabolite biokinetics in non-pregnant sheep. AU - Thordarson,G, AU - McDowell,G H, AU - Smith,S V, AU - Iley,S, AU - Forsyth,I A, PY - 1987/5/1/pubmed PY - 1987/5/1/medline PY - 1987/5/1/entrez SP - 277 EP - 83 JF - The Journal of endocrinology JO - J. Endocrinol. VL - 113 IS - 2 N2 - Continuous intravenous infusions of saline or of a placental extract containing ovine placental lactogen were given to three non-pregnant, non-lactating ewes over periods of 36 h, 1 week apart. During saline infusion no placental lactogen was detected in jugular vein plasma. but infusion of the placental extract raised the placental lactogen concentration from undetectable to 40-50 micrograms/l, similar to concentrations in ewes with one fetus on day 90 of pregnancy. By comparison with the saline control period, infusion of the placental extract consistently increased both plasma concentrations and irreversible loss of nonesterified fatty acids. Plasma concentrations of glucose and urea, but not irreversible loss of these metabolites, were consistently increased. Although the placental extract was not subjected to extensive purification, it was enriched in placental lactogen and contained no detectable contamination with insulin, prolactin or growth hormone. The results are suggestive of a role for placental lactogen in modifying metabolism and acting during pregnancy to provide nutrients for fetal metabolism. SN - 0022-0795 UR - https://www.unboundmedicine.com/medline/citation/3295103/Effects_of_continuous_intravenous_infusion_of_an_ovine_placental_extract_enriched_in_placental_lactogen_on_plasma_hormones_metabolites_and_metabolite_biokinetics_in_non_pregnant_sheep_ L2 - https://joe.bioscientifica.com/doi/10.1677/joe.0.1130277 DB - PRIME DP - Unbound Medicine ER -