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A population-based case-control study on the association of Angelica sinensis exposure with risk of breast cancer.
J Tradit Complement Med. 2020 Sep; 10(5):454-459.JT

Abstract

BACKGROUND

Due to a lack of evidence from large-scale epidemiological studies by far on this issue, whether there is a link between Angelica sinensis exposure and breast cancer risk remained inconclusive.

METHODS

We conducted a population-based case-control study using Taiwan's National Health Insurance claim data, in which all breast cancer patients newly diagnosed between 2005 and 2008 were employed as the case group (n = 34,262) and a random sample of non-breast cancer individuals selected from 1-million beneficiaries registered in 2005 was served as the control group. For fair comparability, we employed the time density sampling method to select controls who were matched to case on date of breast cancer diagnosis and age with a case/control ratio of 1/3 (n = 102,786).

RESULTS

We found that the use of Angelica sinensis presents a weakly but significantly protective effect on breast cancer (adjusted odds ratio (aOR) 0.95, 95% confidence interval (CI) 0.93-0.98), with a significant dose-gradient relationship. We also noted a stronger association with breast cancer with initial use of Angelica sinensis at a longer time before breast cancer diagnosis, and found that the seemingly protective effect of Angelica sinensis was more obvious among women who had initial use at 47-55 years (aOR 0.93, 95% CI 0.88-0.98).

CONCLUSION

This population-based case-control study revealed that exposure to Angelica sinensis showed a weakly but significantly protective effect on breast cancer risk, which could ease people's concern over the potential carcinogenic effect from exposure to Angelica sinensis.

Authors+Show Affiliations

Department of Traditional Chinese Medicine, Kaohsiung Medical University Hospital, Kaohsiung Medical University, No.100, Tzyou 1st Road, Kaohsiung, Taiwan. Department of Public Health, College of Medicine, National Cheng Kung University, No.1, University Road, East District, Tainan, Taiwan.Department of Traditional Chinese Medicine, Kaohsiung Medical University Hospital, Kaohsiung Medical University, No.100, Tzyou 1st Road, Kaohsiung, Taiwan.Department of Epidemiology, Faculty of Public Health, Universitas Airlangga, Kampus C UNAIR, Jl. Mulyorejo Surabaya, East Java, Indonesia.Department of Public Health, College of Medicine, National Cheng Kung University, No.1, University Road, East District, Tainan, Taiwan. Department of Epidemiology, Faculty of Public Health, Universitas Airlangga, Kampus C UNAIR, Jl. Mulyorejo Surabaya, East Java, Indonesia. Department of Public Health, College of Public Health, China Medical University, No.91, Xueshi Road, North District, Taichung, Taiwan.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

32953561

Citation

Chen, Jhong-Yuan, et al. "A Population-based Case-control Study On the Association of Angelica Sinensis Exposure With Risk of Breast Cancer." Journal of Traditional and Complementary Medicine, vol. 10, no. 5, 2020, pp. 454-459.
Chen JY, Wang YH, Hidajah AC, et al. A population-based case-control study on the association of Angelica sinensis exposure with risk of breast cancer. J Tradit Complement Med. 2020;10(5):454-459.
Chen, J. Y., Wang, Y. H., Hidajah, A. C., & Li, C. Y. (2020). A population-based case-control study on the association of Angelica sinensis exposure with risk of breast cancer. Journal of Traditional and Complementary Medicine, 10(5), 454-459. https://doi.org/10.1016/j.jtcme.2019.10.003
Chen JY, et al. A Population-based Case-control Study On the Association of Angelica Sinensis Exposure With Risk of Breast Cancer. J Tradit Complement Med. 2020;10(5):454-459. PubMed PMID: 32953561.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A population-based case-control study on the association of Angelica sinensis exposure with risk of breast cancer. AU - Chen,Jhong-Yuan, AU - Wang,Yi-Hsiu, AU - Hidajah,Atik Choirul, AU - Li,Chung-Yi, Y1 - 2019/10/23/ PY - 2019/03/12/received PY - 2019/10/15/revised PY - 2019/10/19/accepted PY - 2020/9/21/entrez PY - 2020/9/22/pubmed PY - 2020/9/22/medline KW - Angelica sinensis KW - Breast cancer KW - CI, confidence interval KW - Herbal medicine KW - ICD-9-CM, International Classification of Disease 9th version Clinical Modification KW - NHIRD, national health insurance research database KW - OR, odds ratio KW - Phytomedicine KW - TCM, traditional Chinese medicine KW - Traditional Chinese medicine KW - aOR, adjusted odds ratio SP - 454 EP - 459 JF - Journal of traditional and complementary medicine JO - J Tradit Complement Med VL - 10 IS - 5 N2 - BACKGROUND: Due to a lack of evidence from large-scale epidemiological studies by far on this issue, whether there is a link between Angelica sinensis exposure and breast cancer risk remained inconclusive. METHODS: We conducted a population-based case-control study using Taiwan's National Health Insurance claim data, in which all breast cancer patients newly diagnosed between 2005 and 2008 were employed as the case group (n = 34,262) and a random sample of non-breast cancer individuals selected from 1-million beneficiaries registered in 2005 was served as the control group. For fair comparability, we employed the time density sampling method to select controls who were matched to case on date of breast cancer diagnosis and age with a case/control ratio of 1/3 (n = 102,786). RESULTS: We found that the use of Angelica sinensis presents a weakly but significantly protective effect on breast cancer (adjusted odds ratio (aOR) 0.95, 95% confidence interval (CI) 0.93-0.98), with a significant dose-gradient relationship. We also noted a stronger association with breast cancer with initial use of Angelica sinensis at a longer time before breast cancer diagnosis, and found that the seemingly protective effect of Angelica sinensis was more obvious among women who had initial use at 47-55 years (aOR 0.93, 95% CI 0.88-0.98). CONCLUSION: This population-based case-control study revealed that exposure to Angelica sinensis showed a weakly but significantly protective effect on breast cancer risk, which could ease people's concern over the potential carcinogenic effect from exposure to Angelica sinensis. SN - 2225-4110 UR - https://www.unboundmedicine.com/medline/citation/32953561/A_population-based_case-control_study_on_the_association_of_Angelica_sinensis_exposure_with_risk_of_breast_cancer. DB - PRIME DP - Unbound Medicine ER -
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