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Decontamination of SARS-CoV-2 and Other RNA Viruses from N95 Level Meltblown Polypropylene Fabric Using Heat under Different Humidities.
ACS Nano. 2020 10 27; 14(10):14017-14025.AN

Abstract

In March of 2020, the World Health Organization declared a pandemic of coronavirus disease 2019 (COVID-19), caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The pandemic led to a shortage of N95-grade filtering facepiece respirators (FFRs), especially surgical-grade N95 FFRs for protection of healthcare professionals against airborne transmission of SARS-CoV-2. We and others have previously reported promising decontamination methods that may be applied to the recycling and reuse of FFRs. In this study we tested disinfection of three viruses, including SARS-CoV-2, dried on a piece of meltblown fabric, the principal component responsible for filtering of fine particles in N95-level FFRs, under a range of temperatures (60-95 °C) at ambient or 100% relative humidity (RH) in conjunction with filtration efficiency testing. We found that heat treatments of 75 °C for 30 min or 85 °C for 20 min at 100% RH resulted in efficient decontamination from the fabric of SARS-CoV-2, human coronavirus NL63 (HCoV-NL63), and another enveloped RNA virus, chikungunya virus vaccine strain 181/25 (CHIKV-181/25), without lowering the meltblown fabric's filtration efficiency.

Authors+Show Affiliations

Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, Texas 77550, United States.Vitalant Research Institute, San Francisco, California 94118, United States. Division of CryoEM and Bioimaging, SSRL, SLAC National Accelerator Laboratory, Menlo Park, California 94025, United States.Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, Texas 77550, United States.4C Air, Inc., Sunnyvale, California 94089, United States.4C Air, Inc., Sunnyvale, California 94089, United States.Vitalant Research Institute, San Francisco, California 94118, United States.Department of Physics, Stanford University, Stanford, California 94305, United States. Department of Molecular and Cellular Physiology, Stanford, California 94305, United States.Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, Texas 77550, United States. Institute for Human Infections and Immunity, University of Texas Medical Branch, Galveston, Texas 77550, United States.Division of CryoEM and Bioimaging, SSRL, SLAC National Accelerator Laboratory, Menlo Park, California 94025, United States. Department of Bioengineering, Stanford University, Stanford, California 94305, United States.Department of Materials Science and Engineering, Stanford University, Stanford, California 94305, United States. Stanford Institute for Materials and Energy Sciences, SLAC National Accelerator Laboratory, Menlo Park, California 94025, United States.

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, U.S. Gov't, Non-P.H.S.

Language

eng

PubMed ID

32955847

Citation

Campos, Rafael K., et al. "Decontamination of SARS-CoV-2 and Other RNA Viruses From N95 Level Meltblown Polypropylene Fabric Using Heat Under Different Humidities." ACS Nano, vol. 14, no. 10, 2020, pp. 14017-14025.
Campos RK, Jin J, Rafael GH, et al. Decontamination of SARS-CoV-2 and Other RNA Viruses from N95 Level Meltblown Polypropylene Fabric Using Heat under Different Humidities. ACS Nano. 2020;14(10):14017-14025.
Campos, R. K., Jin, J., Rafael, G. H., Zhao, M., Liao, L., Simmons, G., Chu, S., Weaver, S. C., Chiu, W., & Cui, Y. (2020). Decontamination of SARS-CoV-2 and Other RNA Viruses from N95 Level Meltblown Polypropylene Fabric Using Heat under Different Humidities. ACS Nano, 14(10), 14017-14025. https://doi.org/10.1021/acsnano.0c06565
Campos RK, et al. Decontamination of SARS-CoV-2 and Other RNA Viruses From N95 Level Meltblown Polypropylene Fabric Using Heat Under Different Humidities. ACS Nano. 2020 10 27;14(10):14017-14025. PubMed PMID: 32955847.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Decontamination of SARS-CoV-2 and Other RNA Viruses from N95 Level Meltblown Polypropylene Fabric Using Heat under Different Humidities. AU - Campos,Rafael K, AU - Jin,Jing, AU - Rafael,Grace H, AU - Zhao,Mervin, AU - Liao,Lei, AU - Simmons,Graham, AU - Chu,Steven, AU - Weaver,Scott C, AU - Chiu,Wah, AU - Cui,Yi, Y1 - 2020/09/29/ PY - 2020/9/22/pubmed PY - 2020/11/13/medline PY - 2020/9/21/entrez KW - COVID-19 KW - N95 KW - SARS-CoV-2 KW - aerosol KW - coronavirus KW - decontamination KW - humidity SP - 14017 EP - 14025 JF - ACS nano JO - ACS Nano VL - 14 IS - 10 N2 - In March of 2020, the World Health Organization declared a pandemic of coronavirus disease 2019 (COVID-19), caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The pandemic led to a shortage of N95-grade filtering facepiece respirators (FFRs), especially surgical-grade N95 FFRs for protection of healthcare professionals against airborne transmission of SARS-CoV-2. We and others have previously reported promising decontamination methods that may be applied to the recycling and reuse of FFRs. In this study we tested disinfection of three viruses, including SARS-CoV-2, dried on a piece of meltblown fabric, the principal component responsible for filtering of fine particles in N95-level FFRs, under a range of temperatures (60-95 °C) at ambient or 100% relative humidity (RH) in conjunction with filtration efficiency testing. We found that heat treatments of 75 °C for 30 min or 85 °C for 20 min at 100% RH resulted in efficient decontamination from the fabric of SARS-CoV-2, human coronavirus NL63 (HCoV-NL63), and another enveloped RNA virus, chikungunya virus vaccine strain 181/25 (CHIKV-181/25), without lowering the meltblown fabric's filtration efficiency. SN - 1936-086X UR - https://www.unboundmedicine.com/medline/citation/32955847/Decontamination_of_SARS_CoV_2_and_Other_RNA_Viruses_from_N95_Level_Meltblown_Polypropylene_Fabric_Using_Heat_under_Different_Humidities_ L2 - https://doi.org/10.1021/acsnano.0c06565 DB - PRIME DP - Unbound Medicine ER -