Tags

Type your tag names separated by a space and hit enter

Therapeutic use of chlorhexidine in bone marrow transplant patients: case studies.
Oral Surg Oral Med Oral Pathol 1987; 63(6):683-7OS

Abstract

Patients undergoing cytotoxic chemotherapy and radiation therapy often experience severe oral complications during and after treatment despite supervised oral hygiene and conventional antimicrobial regimens. The antimicrobial compound chlorhexidine is an effective topical prophylactic agent against oral mucositis and candidiasis. Oral mucositis developed in four patients who underwent bone marrow transplantation; the condition was severe enough to prompt use of chlorhexidine. In each case, there was clinical resolution of mucositis and a concomitant decrease in the oral microbial burden 1 week after chlorhexidine use began. This strongly suggests that, in addition to its value in protecting these severely immunocompromised patients from oral infection, chlorhexidine also offers a therapeutic benefit in the resolution of existing oral infections and of mucositis.

Authors

No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Case Reports
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

3295655

Citation

Ferretti, G A., et al. "Therapeutic Use of Chlorhexidine in Bone Marrow Transplant Patients: Case Studies." Oral Surgery, Oral Medicine, and Oral Pathology, vol. 63, no. 6, 1987, pp. 683-7.
Ferretti GA, Hansen IA, Whittenburg K, et al. Therapeutic use of chlorhexidine in bone marrow transplant patients: case studies. Oral Surg Oral Med Oral Pathol. 1987;63(6):683-7.
Ferretti, G. A., Hansen, I. A., Whittenburg, K., Brown, A. T., Lillich, T. T., & Ash, R. C. (1987). Therapeutic use of chlorhexidine in bone marrow transplant patients: case studies. Oral Surgery, Oral Medicine, and Oral Pathology, 63(6), pp. 683-7.
Ferretti GA, et al. Therapeutic Use of Chlorhexidine in Bone Marrow Transplant Patients: Case Studies. Oral Surg Oral Med Oral Pathol. 1987;63(6):683-7. PubMed PMID: 3295655.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Therapeutic use of chlorhexidine in bone marrow transplant patients: case studies. AU - Ferretti,G A, AU - Hansen,I A, AU - Whittenburg,K, AU - Brown,A T, AU - Lillich,T T, AU - Ash,R C, PY - 1987/6/1/pubmed PY - 1987/6/1/medline PY - 1987/6/1/entrez SP - 683 EP - 7 JF - Oral surgery, oral medicine, and oral pathology JO - Oral Surg. Oral Med. Oral Pathol. VL - 63 IS - 6 N2 - Patients undergoing cytotoxic chemotherapy and radiation therapy often experience severe oral complications during and after treatment despite supervised oral hygiene and conventional antimicrobial regimens. The antimicrobial compound chlorhexidine is an effective topical prophylactic agent against oral mucositis and candidiasis. Oral mucositis developed in four patients who underwent bone marrow transplantation; the condition was severe enough to prompt use of chlorhexidine. In each case, there was clinical resolution of mucositis and a concomitant decrease in the oral microbial burden 1 week after chlorhexidine use began. This strongly suggests that, in addition to its value in protecting these severely immunocompromised patients from oral infection, chlorhexidine also offers a therapeutic benefit in the resolution of existing oral infections and of mucositis. SN - 0030-4220 UR - https://www.unboundmedicine.com/medline/citation/3295655/Therapeutic_use_of_chlorhexidine_in_bone_marrow_transplant_patients:_case_studies_ L2 - https://medlineplus.gov/bonemarrowtransplantation.html DB - PRIME DP - Unbound Medicine ER -