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Exploring the Role of Aggregated Proteomes in the Pathogenesis of Alzheimer's Disease.
Curr Protein Pept Sci. 2020; 21(12):1164-1173.CP

Abstract

Alzheimer's disease (AD) is a progressive brain disorder and one of the most common causes of dementia and death. AD can be of two types; early-onset and late-onset, where late-onset AD occurs sporadically while early-onset AD results from a mutation in any of the three genes that include amyloid precursor protein (APP), presenilin 1 (PSEN 1) and presenilin 2 (PSEN 2). Biologically, AD is defined by the presence of the distinct neuropathological profile that consists of the extracellular β-amyloid (Aβ) deposition in the form of diffuse neuritic plaques, intraneuronal neurofibrillary tangles (NFTs) and neuropil threads; in dystrophic neuritis, consisting of aggregated hyperphosphorylated tau protein. Elevated levels of (Aβ), total tau (t-tau) and phosphorylated tau (ptau) in cerebrospinal fluid (CSF) have become an important biomarker for the identification of this neurodegenerative disease. The aggregation of Aβ peptide derived from amyloid precursor protein initiates a series of events that involve inflammation, tau hyperphosphorylation and its deposition, in addition to synaptic dysfunction and neurodegeneration, ultimately resulting in dementia. The current review focuses on the role of proteomes in the pathogenesis of AD.

Authors+Show Affiliations

P.G. Department of Pharmacology, College of Pharmaceutical Sciences, Govt. Medical College, Kannur-670503, India.School of Pharmaceutical Sciences, Delhi Pharmaceutical Sciences and Research University, New Delhi-110017, India.College of Pharmaceutical Sciences, Govt. Medical College, Kozhikode-673008, India.Department of Pharmaceutical Chemistry, National College of Pharmacy, Calicut, India.Department of Pharmacy, Southeast University, Dhaka, Bangladesh.Department of Pharmacy, Southeast University, Dhaka, Bangladesh.Department of Pharmaceutical Chemistry, Amrita School of Pharmacy, Amrita Vishwa Vidyapeetham, Amrita Health Science Campus, Kochi-682 041, India.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

32957903

Citation

Narayanan, Siju Ellickal, et al. "Exploring the Role of Aggregated Proteomes in the Pathogenesis of Alzheimer's Disease." Current Protein & Peptide Science, vol. 21, no. 12, 2020, pp. 1164-1173.
Narayanan SE, Sekhar N, Rajamma RG, et al. Exploring the Role of Aggregated Proteomes in the Pathogenesis of Alzheimer's Disease. Curr Protein Pept Sci. 2020;21(12):1164-1173.
Narayanan, S. E., Sekhar, N., Rajamma, R. G., Marathakam, A., Al Mamun, A., Uddin, M. S., & Mathew, B. (2020). Exploring the Role of Aggregated Proteomes in the Pathogenesis of Alzheimer's Disease. Current Protein & Peptide Science, 21(12), 1164-1173. https://doi.org/10.2174/1389203721666200921152246
Narayanan SE, et al. Exploring the Role of Aggregated Proteomes in the Pathogenesis of Alzheimer's Disease. Curr Protein Pept Sci. 2020;21(12):1164-1173. PubMed PMID: 32957903.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Exploring the Role of Aggregated Proteomes in the Pathogenesis of Alzheimer's Disease. AU - Narayanan,Siju Ellickal, AU - Sekhar,Nikhila, AU - Rajamma,Rajalakshmi Ganesan, AU - Marathakam,Akash, AU - Al Mamun,Abdullah, AU - Uddin,Md Sahab, AU - Mathew,Bijo, PY - 2019/12/09/received PY - 2020/03/13/revised PY - 2020/07/28/accepted PY - 2020/9/23/pubmed PY - 2021/5/27/medline PY - 2020/9/22/entrez KW - Alzheimer’s disease KW - Aβ KW - Dementia KW - brain disorder KW - proteomes KW - tau SP - 1164 EP - 1173 JF - Current protein & peptide science JO - Curr Protein Pept Sci VL - 21 IS - 12 N2 - Alzheimer's disease (AD) is a progressive brain disorder and one of the most common causes of dementia and death. AD can be of two types; early-onset and late-onset, where late-onset AD occurs sporadically while early-onset AD results from a mutation in any of the three genes that include amyloid precursor protein (APP), presenilin 1 (PSEN 1) and presenilin 2 (PSEN 2). Biologically, AD is defined by the presence of the distinct neuropathological profile that consists of the extracellular β-amyloid (Aβ) deposition in the form of diffuse neuritic plaques, intraneuronal neurofibrillary tangles (NFTs) and neuropil threads; in dystrophic neuritis, consisting of aggregated hyperphosphorylated tau protein. Elevated levels of (Aβ), total tau (t-tau) and phosphorylated tau (ptau) in cerebrospinal fluid (CSF) have become an important biomarker for the identification of this neurodegenerative disease. The aggregation of Aβ peptide derived from amyloid precursor protein initiates a series of events that involve inflammation, tau hyperphosphorylation and its deposition, in addition to synaptic dysfunction and neurodegeneration, ultimately resulting in dementia. The current review focuses on the role of proteomes in the pathogenesis of AD. SN - 1875-5550 UR - https://www.unboundmedicine.com/medline/citation/32957903/Exploring_the_Role_of_Aggregated_Proteomes_in_the_Pathogenesis_of_Alzheimer's_Disease_ DB - PRIME DP - Unbound Medicine ER -