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A broad perspective on the molecular regulation of retinal ganglion cell degeneration in glaucoma.
Prog Brain Res. 2020; 256(1):49-77.PB

Abstract

Glaucoma is a complex neurodegenerative disease involving RGC axons, somas, and synapses at dendrites and axon terminals. Recent research advancements in the field have revealed a bigger picture of glaucomatous neurodegeneration that encompasses multiple stressors, multiple injury sites, multiple cell types, and multiple signaling pathways for asynchronous degeneration of RGCs during a chronic disease period. Optic nerve head is commonly viewed as the critical site of injury in glaucoma, where early injurious insults initiate distal and proximal signaling for axonal and somatic degeneration. Despite compartmentalized processes for degeneration of RGC axons and somas, there are intricate interactions between the two compartments and mechanistic overlaps between the molecular pathways that mediate degeneration in axonal and somatic compartments. This review summarizes the recent progress in the molecular understanding of RGC degeneration in glaucoma and highlights various etiological paths with biomechanical, metabolic, oxidative, and inflammatory components. Through this growing body of knowledge, the glaucoma community moves closer toward causative treatment of this blinding disease.

Authors+Show Affiliations

Department of Ophthalmology, Vagelos College of Physicians and Surgeons, Columbia University, Edward S. Harkness Eye Institute, New York, NY, United States. Electronic address: gt2320@cumc.columbia.edu.

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

32958215

Citation

Tezel, Gülgün. "A Broad Perspective On the Molecular Regulation of Retinal Ganglion Cell Degeneration in Glaucoma." Progress in Brain Research, vol. 256, no. 1, 2020, pp. 49-77.
Tezel G. A broad perspective on the molecular regulation of retinal ganglion cell degeneration in glaucoma. Prog Brain Res. 2020;256(1):49-77.
Tezel, G. (2020). A broad perspective on the molecular regulation of retinal ganglion cell degeneration in glaucoma. Progress in Brain Research, 256(1), 49-77. https://doi.org/10.1016/bs.pbr.2020.05.027
Tezel G. A Broad Perspective On the Molecular Regulation of Retinal Ganglion Cell Degeneration in Glaucoma. Prog Brain Res. 2020;256(1):49-77. PubMed PMID: 32958215.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A broad perspective on the molecular regulation of retinal ganglion cell degeneration in glaucoma. A1 - Tezel,Gülgün, Y1 - 2020/07/16/ PY - 2020/9/22/entrez PY - 2020/9/23/pubmed PY - 2021/7/6/medline KW - Glaucoma KW - Molecular signaling KW - Neurodegeneration KW - Neuroinflammation KW - Optic nerve axons KW - Retinal ganglion cells SP - 49 EP - 77 JF - Progress in brain research JO - Prog Brain Res VL - 256 IS - 1 N2 - Glaucoma is a complex neurodegenerative disease involving RGC axons, somas, and synapses at dendrites and axon terminals. Recent research advancements in the field have revealed a bigger picture of glaucomatous neurodegeneration that encompasses multiple stressors, multiple injury sites, multiple cell types, and multiple signaling pathways for asynchronous degeneration of RGCs during a chronic disease period. Optic nerve head is commonly viewed as the critical site of injury in glaucoma, where early injurious insults initiate distal and proximal signaling for axonal and somatic degeneration. Despite compartmentalized processes for degeneration of RGC axons and somas, there are intricate interactions between the two compartments and mechanistic overlaps between the molecular pathways that mediate degeneration in axonal and somatic compartments. This review summarizes the recent progress in the molecular understanding of RGC degeneration in glaucoma and highlights various etiological paths with biomechanical, metabolic, oxidative, and inflammatory components. Through this growing body of knowledge, the glaucoma community moves closer toward causative treatment of this blinding disease. SN - 1875-7855 UR - https://www.unboundmedicine.com/medline/citation/32958215/A_broad_perspective_on_the_molecular_regulation_of_retinal_ganglion_cell_degeneration_in_glaucoma_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0079-6123(20)30069-8 DB - PRIME DP - Unbound Medicine ER -