Abstract
Glaucoma is a complex neurodegenerative disease involving RGC axons, somas, and synapses at dendrites and axon terminals. Recent research advancements in the field have revealed a bigger picture of glaucomatous neurodegeneration that encompasses multiple stressors, multiple injury sites, multiple cell types, and multiple signaling pathways for asynchronous degeneration of RGCs during a chronic disease period. Optic nerve head is commonly viewed as the critical site of injury in glaucoma, where early injurious insults initiate distal and proximal signaling for axonal and somatic degeneration. Despite compartmentalized processes for degeneration of RGC axons and somas, there are intricate interactions between the two compartments and mechanistic overlaps between the molecular pathways that mediate degeneration in axonal and somatic compartments. This review summarizes the recent progress in the molecular understanding of RGC degeneration in glaucoma and highlights various etiological paths with biomechanical, metabolic, oxidative, and inflammatory components. Through this growing body of knowledge, the glaucoma community moves closer toward causative treatment of this blinding disease.
Pub Type(s)
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Review
TY - JOUR
T1 - A broad perspective on the molecular regulation of retinal ganglion cell degeneration in glaucoma.
A1 - Tezel,Gülgün,
Y1 - 2020/07/16/
PY - 2020/9/22/entrez
PY - 2020/9/23/pubmed
PY - 2021/7/6/medline
KW - Glaucoma
KW - Molecular signaling
KW - Neurodegeneration
KW - Neuroinflammation
KW - Optic nerve axons
KW - Retinal ganglion cells
SP - 49
EP - 77
JF - Progress in brain research
JO - Prog Brain Res
VL - 256
IS - 1
N2 - Glaucoma is a complex neurodegenerative disease involving RGC axons, somas, and synapses at dendrites and axon terminals. Recent research advancements in the field have revealed a bigger picture of glaucomatous neurodegeneration that encompasses multiple stressors, multiple injury sites, multiple cell types, and multiple signaling pathways for asynchronous degeneration of RGCs during a chronic disease period. Optic nerve head is commonly viewed as the critical site of injury in glaucoma, where early injurious insults initiate distal and proximal signaling for axonal and somatic degeneration. Despite compartmentalized processes for degeneration of RGC axons and somas, there are intricate interactions between the two compartments and mechanistic overlaps between the molecular pathways that mediate degeneration in axonal and somatic compartments. This review summarizes the recent progress in the molecular understanding of RGC degeneration in glaucoma and highlights various etiological paths with biomechanical, metabolic, oxidative, and inflammatory components. Through this growing body of knowledge, the glaucoma community moves closer toward causative treatment of this blinding disease.
SN - 1875-7855
UR - https://www.unboundmedicine.com/medline/citation/32958215/A_broad_perspective_on_the_molecular_regulation_of_retinal_ganglion_cell_degeneration_in_glaucoma_
L2 - https://linkinghub.elsevier.com/retrieve/pii/S0079-6123(20)30069-8
DB - PRIME
DP - Unbound Medicine
ER -
